Laser Ionization in Single‐Particle Mass Spectrometry

Passig, Johannes; Zimmermann, Ralf

doi:10.1002/9783527682201.ch11

Cited by 11 publications

(8 citation statements)

References 201 publications

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“…When referenced to an independent particle‐size distribution measurement, SPMS methods can produce quantitative estimates of the available aerosol surface area (Cziczo et al., 2009; Froyd et al., 2019; Qin et al., 2006; Zawadowicz et al., 2015). A detailed description of different SPMS instruments and methods, including their relative sensitivities to different aerosol types and/or sizes, can be found in dedicated reviews (e.g., Murphy, 2007; Nash et al., 2006; Passig & Zimmermann, 2021; Pratt & Prather, 2012).…”

Section: Ice Nucleation Parameterizationsmentioning

confidence: 99%

Ice‐Nucleating Particles That Impact Clouds and Climate: Observational and Modeling Research Needs

Burrows

McCluskey

Cornwell

et al. 2022

Reviews of Geophysics

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Atmospheric ice‐nucleating particles (INPs) play a critical role in cloud freezing processes, with important implications for precipitation formation and cloud radiative properties, and thus for weather and climate. Additionally, INP emissions respond to changes in the Earth System and climate, for example, desertification, agricultural practices, and fires, and therefore may introduce climate feedbacks that are still poorly understood. As knowledge of the nature and origins of INPs has advanced, regional and global weather, climate, and Earth system models have increasingly begun to link cloud ice processes to model‐simulated aerosol abundance and types. While these recent advances are exciting, coupling cloud processes to simulated aerosol also makes cloud physics simulations increasingly susceptible to uncertainties in simulation of INPs, which are still poorly constrained by observations. Advancing the predictability of INP abundance with reasonable spatiotemporal resolution will require an increased focus on research that bridges the measurement and modeling communities. This review summarizes the current state of knowledge and identifies critical knowledge gaps from both observational and modeling perspectives. In particular, we emphasize needs in two key areas: (a) observational closure between aerosol and INP quantities and (b) skillful simulation of INPs within existing weather and climate models. We discuss the state of knowledge on various INP particle types and briefly discuss the challenges faced in understanding the cloud impacts of INPs with present‐day models. Finally, we identify priority research directions for both observations and models to improve understanding of INPs and their interactions with the Earth System.

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Section: Ice Nucleation Parameterizationsmentioning

confidence: 99%

Ice‐Nucleating Particles That Impact Clouds and Climate: Observational and Modeling Research Needs

Burrows

McCluskey

Cornwell

et al. 2022

Reviews of Geophysics

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“…This process called laser desorption/ionization (LDI) allows to analyze individual particles from polydisperse particle matter. The working scheme of a SPMS system is illustrated in Figure 1 [8].…”

Section: Materials 21 Experimental Set-upmentioning

confidence: 99%

“…Based on photo-ionization and time-offlight mass spectrometry (TOF-MS), SPMS allows for the identification of chemical signatures of individual non-volatile (aerosol) particles, enabling large chemical coverage. It has the unique capability of chemically characterizing the analyte on a particle-by-particle basis without involving complicated sample preparation, with measurement rates of up to 100 Hz [8]. Identification methods rely on recognition of spectral fragments and patterns of spectral lines in the bipolar mass spectra, which are characteristic for different agents.…”

Section: Introductionmentioning

confidence: 99%

Real-time particle analysis of explosives compounds using single-particle mass spectrometry

Ruser,

Schade,

Jeong

et al. 2024

Next-Generation Spectroscopic Technologies XVI

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The detection of trace amounts of hazardous agents has become crucial for protection of human life, infrastructure and the environment. Single-particle mass spectrometry (SPMS) has proven to be a sensitive measurement technique for instantly revealing the chemical composition of individual, potentially harmful aerosol and dust particles. In this study, we focus on profiling non-volatile particles of explosive compounds in powdered form. It is reported, how the unique SPMS technology, based on (1) particle velocimetry and sizing, (2) sophisticated laser ionization and (3) bipolar time-offlight mass spectrometry (TOF-MS) has been tailored and applied for the detection of individual particles of common explosive substances in the micro-and nanometer range. Out of more than 30 different types of military and home-made explosives, which were investigated in our recent laboratory measurements, the mass spectra of 12 commonly used explosives compounds are examined. Steps are described for automated and reliable identification of characteristic spectral markers of each of the explosives in their respective mass spectra.

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“…SPMS is a well-known technique for online real-time detection of size and chemical composition at the single-particle level; thus, it has been widely used in the studies of aerosol transformation, global climate change, etc . The application of SPMS in detecting bioaerosols at the single-particle level began in the early 2000s. − Wuijckhuijse et al developed a bioaerosol mass spectrometer with various functions, including particle sizing, bioaerosol particle screening, and chemical composition detection. The bioaerosol particles are screened out based on their fluorescence emission induced with a 266 nm laser.…”

Section: Real-time Detection Of Bioaerosols Using Single-particle Mas...mentioning

confidence: 99%

In Situ Characterization of Bioaerosols at the Single-Particle Level Using Single-Particle Mass Spectrometry: A Promising Tool for Defending Human Health against Bioaerosol Transmission

Lei

Wexler

et al. 2023

Anal. Chem.

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Bioaerosol transmission is one of the important transmission pathways of COVID-19 and other infectious respiratory diseases caused by viral infection. The ability to detect bioaerosols and characterize encapsulated pathogens both in situ and in real time is crucial for early warning and monitoring of the progress of an epidemic or pandemic. The lack of a powerful analytical tool for distinguishing between bioaerosols and nonbioaerosols as well as for identification of pathogen species contained in the bioaerosols is the bottleneck in related fields. Herein, a promising solution for in situ and real-time accurate and sensitive detection of bioaeorosols is proposed by integrating single-particle aerosol mass spectrometry, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, and fluorescence spectroscopy. The proposed mass spectrometry aims at detecting bioaerosols in a range of 0.5–10 μm with adequate sensitivity and specificity. This single-particle bioaerosol mass spectrometry would not only be a powerful tool that can be useful for the authorities and public health monitoring but also would be an example of advances in mass spectrometry.

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Laser Ionization in Single‐Particle Mass Spectrometry

Cited by 11 publications

References 201 publications

Ice‐Nucleating Particles That Impact Clouds and Climate: Observational and Modeling Research Needs

Ice‐Nucleating Particles That Impact Clouds and Climate: Observational and Modeling Research Needs

Real-time particle analysis of explosives compounds using single-particle mass spectrometry

In Situ Characterization of Bioaerosols at the Single-Particle Level Using Single-Particle Mass Spectrometry: A Promising Tool for Defending Human Health against Bioaerosol Transmission

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