Laser microfabrication of long thin holes on biodegradable polymer in vacuum for preventing clogginess and its application to blood collection

Aoyagi, Shigeaki; Izumi, Hayato; Ochi, Mitsukazu; Ogawa, Hiroshi

doi:10.1016/j.sna.2008.01.019

Cited by 12 publications

(5 citation statements)

References 6 publications

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“…These materials were used for blood collection. Gaseous degradation products were detected by GC/MS (231). ESI-MS gave valuable insights into the hydrolysis of biodegradable homo-and copolyesters of 1,5-dioxepan-2-one and ε-caprolactone and showed that hydrophilicity of the polymer as well as copolymer architecture both greatly influenced the water-soluble degradation product patterns (232).…”

Section: Synthesis Of Polymersmentioning

confidence: 99%

Mass Spectrometry of Synthetic Polymers

2010

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Section: Synthesis Of Polymersmentioning

confidence: 99%

Mass Spectrometry of Synthetic Polymers

2010

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“…Polymeric soften was maneuvered into the form by use of vacuum, followed by freezing for division of the ace structure from the shape. Aoyagi et al considered formulation of biodegradable polymers under typical barometrical conditions [108]. Chen et al introduced a strong Gasstream covering technique to accomplish uniform covering of a scope of immunetherapeutics, similar to antigens, DNA and proteins, on microneedles [95].…”

Section: 3 Itchingmentioning

confidence: 99%

Microneedles based drug delivery systems: an updated review

Gulati

Pannu

Kumar

et al. 2022

ijhs

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Transdermal drug delivery systems (TDDS) are used to deliver the drug(s) or the therapeutically active substances through topical route primarily through skin. Relatively very small numbers of drugs are administered transdermally because in many cases the physical properties of drugs, including polarity and molecular size, have limited its capacity to deliver the particular dug transdermally. Now a day’s transdermal drug delivery techniques are used in various therapeutic areas like motion sickness management, heart disease treatment, hormones replacement, management of pain and smoking cessation etc. TDDS increases the potency of drugs and decreases the relative side effects. We reviewed different approaches used to enhance the drug delivery transdermally (e.g., particulate and vesicle based method, modified stratum corneum method, electrically based method, vehicle interaction method, removed stratum corneum method). As the stratum corneum is the main barrier in transdermal drug delivery, so the approaches can also be classified in three main categories in order to circumventing the barriers related to stratum corneum only (based on drug vehicle, chemical enhancers, physical enhancers). Here we focused mainly on the microneedles (MNs) based approach for transdermal drug delivery.

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“…[42] Polylactic acid microneedles were blocked because of formation of hydrolysed intermediate products of polylactic acid. This intermediate product was not formed under vacuum laser microfabrication of needles.…”

Section: Fabrication Of Microneedlesmentioning

confidence: 99%

“…Aoyagi et al . studied microfabrication of biodegradable polymers under normal atmospheric conditions [42] . Polylactic acid microneedles were blocked because of formation of hydrolysed intermediate products of polylactic acid.…”

Section: Fabrication Of Microneedlesmentioning

confidence: 99%

Microneedles: an emerging transdermal drug delivery system

Bariya

Gohel

Mehta

et al. 2012

Journal of Pharmacy and Pharmacology

357

207

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Objectives One of the thrust areas in drug delivery research is transdermal drug delivery systems (TDDS) due to their characteristic advantages over oral and parenteral drug delivery systems. Researchers have focused their attention on the use of microneedles to overcome the barrier of the stratum corneum. Microneedles deliver the drug into the epidermis without disruption of nerve endings. Recent advances in the development of microneedles are discussed in this review for the benefit of young scientists and to promote research in the area. Key findings Microneedles are fabricated using a microelectromechanical system employing silicon, metals, polymers or polysaccharides. Solid coated microneedles can be used to pierce the superficial skin layer followed by delivery of the drug. Advances in microneedle research led to development of dissolvable/degradable and hollow microneedles to deliver drugs at a higher dose and to engineer drug release. Iontophoresis, sonophoresis and electrophoresis can be used to modify drug delivery when used in concern with hollow microneedles. Microneedles can be used to deliver macromolecules such as insulin, growth hormones, immunobiologicals, proteins and peptides. Microneedles containing 'cosmeceuticals' are currently available to treat acne, pigmentation, scars and wrinkles, as well as for skin tone improvement. Summary Literature survey and patents filled revealed that microneedle-based drug delivery system can be explored as a potential tool for the delivery of a variety of macromolecules that are not effectively delivered by conventional transdermal techniques.

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Laser microfabrication of long thin holes on biodegradable polymer in vacuum for preventing clogginess and its application to blood collection

Cited by 12 publications

References 6 publications

Mass Spectrometry of Synthetic Polymers

Mass Spectrometry of Synthetic Polymers

Microneedles based drug delivery systems: an updated review

Microneedles: an emerging transdermal drug delivery system

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