Energy released from beta emission causes molecules that incorporate tritium (3H) and carbon‐14 (14C) atoms to be less stable than their stable labeled counterparts, thus making radiolabeled compounds prone to self‐radiolysis. This literature review examines the stability of organic compounds incorporating 3H and 14C atoms and discusses stability of the compound with respect to functional groups within the radiolabeled molecules. The goal of this paper is to serve as a reference for the stability of radiolabeled compounds.