Eyelid is one of the thinnest skins in the human body. Periocular fine lines and wrinkles usually appear as a first visible sign of facial aging, which become a major battlefield for an aging person. 1,2 Many factors contribute to periocular skin aging, such as collagen deficiency, shifting gravity, photoaging, and skin atrophy. 3 The treatment of periocular regions is quite challenging for a clinician due to their thinness in skin and particular anatomic locations. The current treatment options for periocular wrinkles include surgery,