Laser-scribed graphene sensor based on gold nanostructures and molecularly imprinted polymers: Application for Her-2 cancer biomarker detection

Lahcen, Abdellatif Ait; Rauf, Sakandar; Aljedaibi, Abdulrahman; Filho, José Ilton de Oliveira; Bedük, Tutku; Mani, Veerappan; Alshareef, Husam N.; Salama, Khaled N.

doi:10.1016/j.snb.2021.130556

Cited by 55 publications

(25 citation statements)

References 54 publications

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“…An example of such a material which is intensively used in the electrochemical analysis of biological compounds, including cancer biomarkers, is graphene. Graphene improves the analytical performance of platforms due to its excellent electrical and thermal conductivity, mechanical strength, large surface area, and the possibility of being further functionalized with various compounds or nanostructures [ 13 , 40 , 69 ]. The development of portable (bio)sensors based on nanomaterials and composite materials is also related with the discovery of versatile materials, which in addition to special conductive properties, must be suitable for functionalization and structural handling.…”

Section: Biomarkers Involved In Inflammatory Diseasesmentioning

confidence: 99%

“…Exploiting these advantages, a MIP sensor was developed using electrodes functionalized with graphene, nanostructured gold, and MIPs obtained after the electro-polymerization. All these components embedded together in the film deposited on the surface of the transducer allowed the selective and high-sensitivity detection of HER2in spiked undiluted serum [ 40 ].…”

Section: Biomarkers Involved In Inflammatory Diseasesmentioning

confidence: 99%

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Point-of-care electrochemical testing of biomarkers involved in inflammatory and inflammatory-associated medical conditions

et al. 2022

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Recent years have shown that the diagnosis and monitoring of biomarkers involved in inflammatory-associated medical conditions such as cancer, neurological disorders, viral infections, or daily physical activities offer real benefits in increasing the quality of medical care and patient life quality. In this context, the use of integrated and portable platforms as point-of-care testing devices for biomedical analysis to enable early disease diagnosis and monitoring, which can be successfully used even at the patient’s bed, is an emergency nowadays. The development of low-cost, miniaturized, and portable, user-friendly devices that provide an answer in a timely manner, such as electrochemical sensors, is relevant for the elaboration of point-of-care testing devices. This review focuses on the recent progress in bioanalysis of both specific biomarkers and inflammatory-associated biomarkers present in several diseases like neoplasia, severe neurological disorders, viral infections, and usual physical activity and provides an overview of the state of the art over the most recent electrochemical (bio)sensors for the detection of inflammation-related biomarkers. Future perspectives of point-of-care testing to improve healthcare management are also discussed. Graphical abstract

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Section: Biomarkers Involved In Inflammatory Diseasesmentioning

confidence: 99%

Section: Biomarkers Involved In Inflammatory Diseasesmentioning

confidence: 99%

Point-of-care electrochemical testing of biomarkers involved in inflammatory and inflammatory-associated medical conditions

et al. 2022

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“…In this context, since wearable biosensors offer outstanding properties such as high accuracy, ease of use, and cost-effectiveness as POC tools, they can be very useful to fulfil the requirements in the field. 39,[159][160][161] These platforms have gained increasing attention thanks to their high potential in various applications, especially for the real-time monitoring of health parameters at POC settings. 14,137,162 Earlier, a plethora of wearable physical sensors has been widely investigated to address the high need in monitoring biophysical signals including respiration rate, vascular dynamics, brain activity and skin temperature.…”

Section: Current Challenges and Prospectsmentioning

confidence: 99%

Biorecognition elements

Lahcen

2022

Wearable Physical, Chemical and Biological Sensors

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“…MIP-based electrochemical sensors show robustness, high stability, sensitivity, and selectivity due to the specific template fabrication toward the target analyte, providing easy recognition and reusability of the sensing platform ( Lahcen et al, 2017 ). Moreover, the presence of a nanoparticle layer, such as gold nanoparticle (AuNP) modification prior to MIP electrosynthesis, provides a stable electroactive support for EDOT (3,4-ethylenedioxythiophene) polymerization in the presence of a template molecule ( Lahcen et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

A Portable Molecularly Imprinted Sensor for On-Site and Wireless Environmental Bisphenol A Monitoring

et al. 2022

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The detection of pollutant traces in the public and environmental waters is essential for safety of the population. Bisphenol A (BPA) is a toxic chemical widely used for the production of food storage containers by plastic industries to increase the storage ability. However, the insertion of BPA in water medium leads to serious health risks. Therefore, the development of low-cost, practical, sensitive, and selective devices to monitor BPA levels on-site in the environment is highly needed. Herein, for the first time, we present a homemade portable potentiostat device integrated to a laser-scribed graphene (LSG) sensor for BPA detection as a practical environmental pollutant monitoring tool. Recently, there has been an increasing need regarding the development of graphene-based electrochemical transducers (e.g., electrodes) to obtain efficient biosensing platforms. LSG platform is combined with molecularly imprinted polymer (MIP) matrix. LSG electrodes were modified with gold nanostructures and PEDOT polymer electrodeposition to create a specific MIP biomimetic receptor for ultrasensitive BPA detection. The sensing device has a Bluetooth connection, wirelessly connected to a smartphone providing high sensitivity and sensitivity (LOD: 3.97 nM in a linear range of .01–10 µM) toward BPA. Two commercial bottled water samples, tap water, commercial milk, and baby formula samples have been used to validate the reliability of the portable sensor device.

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Laser-scribed graphene sensor based on gold nanostructures and molecularly imprinted polymers: Application for Her-2 cancer biomarker detection

Cited by 55 publications

References 54 publications

Point-of-care electrochemical testing of biomarkers involved in inflammatory and inflammatory-associated medical conditions

Point-of-care electrochemical testing of biomarkers involved in inflammatory and inflammatory-associated medical conditions

Biorecognition elements

A Portable Molecularly Imprinted Sensor for On-Site and Wireless Environmental Bisphenol A Monitoring

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