Laser surface modification of ultra-high-molecular-weight polyethylene (UHMWPE) for biomedical applications

Riveiro, A.; Soto, R.; Val, J. del; Comesaña, R.; Boutinguiza, M.; Quintero, F.; Lusquiños, F.; Pou, J.

doi:10.1016/j.apsusc.2014.02.130

Cited by 62 publications

(40 citation statements)

References 23 publications

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“…5 The production process of UHMWPE fibers called gel spinning determines whether the degree of crystallinity and the level of macromolecular orientation of the product were high, which could help the product to get a high tenacity. 6,7 However, some problems such as low surface energy and poor surface adhesion constrain its applications.…”

Section: Introductionmentioning

confidence: 99%

“…Several methods such as gamma irradiation, chemical grafting, laser texturing modifications, and plasma surface treatment have been studied. 5,[13][14][15] Most of the recent works have been focused on the designing of the coating methods, which should protect the bone tissue from periprostheticosteolysis and improve the biocompatibility of the material. Nylon coating, 16 titanium and hydroxyapatite coating, 17 and gold coating 18 showed effectiveness on the improvement of biological performance of UHMWPE.…”

Section: Introductionmentioning

confidence: 99%

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Surface modification of vascular endothelial growth factor-loaded silk fibroin to improve biological performance of ultra-high-molecular-weight polyethylene via promoting angiogenesis

Ai¹,

Sheng²,

Cai³

et al. 2017

IJN

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Ultra-high-molecular-weight polyethylene (UHMWPE) has been applied in orthopedics, as the materials of joint prosthesis, artificial ligaments, and sutures due to its advantages such as high tensile strength, good wear resistance, and chemical stability. However, postoperative osteolysis induced by UHMWPE wear particles and poor bone–implant healing interface due to scarcity of osseointegration is a significant problem and should be solved imperatively. In order to enhance its affinity to bone tissue, vascular endothelial growth factor (VEGF) was loaded on the surface of materials, the loading was performed by silk fibroin (SF) coating to achieve a controlled-release delivery. Several techniques including field emission scanning electron microscopy (FESEM) and attenuated total reflectance (ATR)-Fourier transform infrared (FTIR) and water contact angle measurement were used to validate the effectiveness of introduction of SF/VEGF. The result of ELISA demonstrated that the release of VEGF was well maintained up to 4 weeks. The modified UHMWPE was evaluated by both in vitro and in vivo experiments. According to the results of FESEM and cell counting kit-8 (CCK-8) assay, bone marrow mesenchymal stem cells cultured on the UHMWPE coated with SF/VEGF and SF exhibited a better proliferation performance than that of the pristine UHMWPE. The model rabbit of anterior cruciate ligament reconstruction was used to observe the graft–bone healing process in vivo. The results of histological evaluation, microcomputed tomography (micro-CT) analysis, and biomechanical tests performed at 6 and 12 weeks after surgery demonstrated that graft–bone healing could be significantly improved due to the effect of VEGF on angiogenesis, which was loaded on the surface by SF coating. This study showed that the method loading VEGF on UHMWPE by SF coating played an effective role on the biological performance of UHMWPE and displayed a great potential application for anterior cruciate ligament reconstruction.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Surface modification of vascular endothelial growth factor-loaded silk fibroin to improve biological performance of ultra-high-molecular-weight polyethylene via promoting angiogenesis

Ai¹,

Sheng²,

Cai³

et al. 2017

IJN

View full text Add to dashboard Cite

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“…It is commonly used in biomedical applications such as in patella or hip prostheses [51,55]. This is principally due to its high wear and impact resistance, chemical stability, and non-toxicity in contact with corporal fluids.…”

Section: Ultra-high-molecular-weight Polyethylene (Uhmwpe)mentioning

confidence: 99%

“…Riveiro et al studied the modification of UHMWPE with several laser wavelengths (1,064, 532, and 355 nm) [55]. In this work, a carbon coating was applied on the surface of the UHMWPE samples to reduce the large transparency exhibited by this material to these laser wavelengths.…”

Section: Ultra-high-molecular-weight Polyethylene (Uhmwpe)mentioning

confidence: 99%

Laser Surface Texturing of Polymers for Biomedical Applications

et al. 2018

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Polymers are materials widely used in biomedical science because of their biocompatibility, and good mechanical properties (which, in some cases, are similar to those of human tissues); however, these materials are, in general, chemically and biologically inert. Surface characteristics, such as topography (at the macro-, micro, and nano-scale), surface chemistry, surface energy, charge, or wettability are interrelated properties, and they cooperatively influence the biological performance of materials when used for biomedical applications. They regulate the biological response at the implant/tissue interface (e.g., influencing the cell adhesion, cell orientation, cell motility, etc.). Several surface processing techniques have been explored to modulate these properties for biomedical applications. Despite their potentials, these methods have limitations that prevent their applicability. In this regard, laser-based methods, in particular laser surface texturing (LST), can be an interesting alternative. Different works have showed the potentiality of this technique to control the surface properties of biomedical polymers and enhance their biological performance; however, more research is needed to obtain the desired biological response. This work provides a general overview of the basics and applications of LST for the surface modification of polymers currently used in the clinical practice (e.g., PEEK, UHMWPE, PP, etc.). The modification of roughness, wettability, and their impact on the biological response is addressed to offer new insights on the surface modification of biomedical polymers.

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“…The biological response on the performed surface materials modification is strongly dependent on the changes in surface properties (e.g., surface morphology, roughness, and composition). The modification of the surface of carbon-coated high-molecular-weight polyethylene (HMWPE) by different laser wavelengths (λ = 1064, 532, and 355 nm) was conducted [25]. The influence of experimental conditions (pulse frequency, scanning speed, and spot overlapping) on the changes in the surface properties of material was studied.…”

Section: Introductionmentioning

confidence: 99%

Wettability and Other Surface Properties of Modified Polymers

Kasálková¹,

Slepička²,

Kolská³

et al. 2015

Wetting and Wettability

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Surface wettability is one of the crucial characteristics for determining of a material's use in specific application. Determination of wettability is based on the measurement of the material surface contact angle. Contact angle is the main parameter that characterizes the drop shape on the solid surface and is also one of the directly measurable properties of the phase interface. In this chapter, the wettability and its related properties of pristine and modified polymer foils will be described. The wettability depends on surface roughness and chemical composition. Changes of these parameters can adjust the values of contact angle and, therefore, wettability. In the case of pristine polymer materials, their wettability is unsuitable for a wide range of applications (such as tissue engineering, printing, and coating). Polymer surfaces can easily be modified by, e.g., plasma discharge, whereas the bulk properties remain unchanged. This modification leads to oxidation of the treated layer and creation of new chemical groups that mainly contain oxygen. Immediately after plasma treatment, the values of the contact angles of the modified polymer significantly decrease.In the case of a specific polymer, the strongly hydrophilic surface is created and leads to total spreading of the water drop. Wettability is strongly dependent on time from modification.Wettability plays a key role, e.g., in the development of biomaterials in tissue engineering and regenerative medicine. Biocompatibility tests of the cell adhesion, proliferation and viability are performed in an aqueous medium, and it is necessary to control the surface wettability. Various cell types have different requirements on surface properties, but while maintaining suitable parameters, the optimal value of © 2015 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.water contact angle for cell adhesion is in the interval of 50-70°. In the case of polymers, which have usually higher values of contact angles, the decrease in water contact angle and adjustment of the surface may be accomplished by introducing selected chemical groups (by plasma treatment), chemical compounds (by grafting, i.e., chemical bath deposition), or nanoparticles. In the case of grafting of polyethylene glycol (PEG) on the plasma activated high-density polyethylene was under "properly" selected conditions of modification (molecular weight of PEG, concentration of PEG in solution) prepared layers that positively influenced the cell adhesion. In addition, low concentration of gold nanoparticles increased the number of adhered cells without decreasing cell viability.Whether the surface of the polymeric substrate is attractive for the adhesion and proliferation of cells is determined not only by wettability but also by a range of other surface properties...

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Laser surface modification of ultra-high-molecular-weight polyethylene (UHMWPE) for biomedical applications

Cited by 62 publications

References 23 publications

Surface modification of vascular endothelial growth factor-loaded silk fibroin to improve biological performance of ultra-high-molecular-weight polyethylene via promoting angiogenesis

Surface modification of vascular endothelial growth factor-loaded silk fibroin to improve biological performance of ultra-high-molecular-weight polyethylene via promoting angiogenesis

Laser Surface Texturing of Polymers for Biomedical Applications

Wettability and Other Surface Properties of Modified Polymers

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