Laser-synthesized TiN nanoparticles for biomedical applications: Evaluation of safety, biodistribution and pharmacokinetics

Zelepukin, Ivan V.; Popov, Anton A.; Shipunova, Victoria O.; Tikhonowski, Gleb V.; Mirkasymov, Aziz B.; Popova-Kuznetsova, Elena; Klimentov, S. M.; Kabashin, Andrei V.; Deyev, Sergey M.

doi:10.1016/j.msec.2020.111717

Cited by 60 publications

(47 citation statements)

References 65 publications

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“…In‐vivo studies reported the accumulation of PEG‐TiN nanoparticles in liver and spleen tissue. However, no hepatic kidney or major organ dysfunction was observed 32,33 . Blood and urea samples from TiN nanoparticles injected in mice, also showed low toxicity levels, and no signs of kidney dysfunction was observed 33 …”

Section: Introductionmentioning

confidence: 95%

“…A few studies have already confirmed the biocompatibility of TiN 27‐29 . For these reasons, there has been a growing interest in the development and application of TiN‐based nanostructures for bio‐applications 30‐34 . Although agglomeration of bare TiN nanoparticles dispersed in high ionic strength liquids and serum‐containing media were reported, the addition of Silicon (Si) 30 and polyethylene glycol (PEG) 32 coating allowed the dispersion of these nanoparticles in physiological media.…”

Section: Introductionmentioning

confidence: 99%

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Laser‐induced cavitation in plasmonic nanoparticle solutions: A comparative study between gold and titanium nitride

Sabzeghabae

Berrospe‐Rodriguez

Mangolini

et al. 2021

J Biomedical Materials Res

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In this work, we present an extensive comparative study between novel titanium nitride nanoparticles (TiN NPs) and commercial gold nanorods (GNR), both dispersed in water and exposed to a pulsed laser‐induced cavitation process. The optical density, shockwave emission, and bubble formation of these solutions were investigated using shadowgraphy, spatial transmittance modulation, and acoustic measurements. TiN nanoparticle solutions exhibited high stability undser a periodic nanosecond pulsed‐laser irradiation, making these nanomaterials promising agents for high‐power applications. In addition, they demonstrated a stronger nonlinear absorption compared to the GNR solutions, and plasma formation at lower laser energies. This study advances our understanding of the optical properties of TiN and discusses significant differences compared to gold, with important implications for future applications of this material in water treatment, nonlinear signal converting, and laser‐induced cavitation for medical implementations, among others.

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Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Laser‐induced cavitation in plasmonic nanoparticle solutions: A comparative study between gold and titanium nitride

Sabzeghabae

Berrospe‐Rodriguez

Mangolini

et al. 2021

J Biomedical Materials Res

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“…On the other hand, having a strong and broad plasmonic peak around 640–700 nm with a significant tail over 800 nm, even for small NPs sizes (<7 nm) [ 40 ], bare laser-synthesized titanium nitride (TiN) nanoparticles seem to be an extremely promising functional element for such hybrid nanofiber platforms. As shown in recent studies [ 37 , 38 , 41 ], TiN NPs have very low toxicity in vitro and in vivo , as well as initiating a strong photothermal therapeutic effect under near-infrared laser irradiation in the region of relative tissue transparency. It is also important that PCL is soluble in acetone, while femtosecond laser ablation makes possible the synthesis of stable solutions of TiN NPs in acetone, which simplifies their co-electrospinning.…”

Section: Introductionmentioning

confidence: 99%

Smart Electrospun Hybrid Nanofibers Functionalized with Ligand-Free Titanium Nitride (TiN) Nanoparticles for Tissue Engineering

et al. 2021

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Herein, we report the fabrication and characterization of novel polycaprolactone (PCL)-based nanofibers functionalized with bare (ligand-free) titanium nitride (TiN) nanoparticles (NPs) for tissue engineering applications. Nanofibers were prepared by a newly developed protocol based on the electrospinning of PCL solutions together with TiN NPs synthesized by femtosecond laser ablation in acetone. The generated hybrid nanofibers were characterised using spectroscopy, microscopy, and thermal analysis techniques. As shown by scanning electron microscopy measurements, the fabricated electrospun nanofibers had uniform morphology, while their diameter varied between 0.403 ± 0.230 µm and 1.1 ± 0.15 µm by optimising electrospinning solutions and parameters. Thermal analysis measurements demonstrated that the inclusion of TiN NPs in nanofibers led to slight variation in mass degradation initiation and phase change behaviour (Tm). In vitro viability tests using the incubation of 3T3 fibroblast cells in a nanofiber-based matrix did not reveal any adverse effects, confirming the biocompatibility of hybrid nanofiber structures. The generated hybrid nanofibers functionalized with plasmonic TiN NPs are promising for the development of smart scaffold for tissue engineering platforms and open up new avenues for theranostic applications.

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“…Lipid-based [2], polymeric [3], metal [4] and silica [5] nanoparticles have been welldocumented, especially in the area of biomedicine and pharmaceutical sciences. The reported nanoparticles reveal enhanced therapeutic effects and/or mitigated system toxicities [6][7][8], creating new possibilities for the theranostics of diseases like tumors [9], diabetes [10] and neurodegeneration [11]. Seemingly, the clinical translation of nanoparticles embraces a bright future.…”

Section: Introductionmentioning

confidence: 99%

Bibliometric landscape of the researches on protein corona of nanoparticles

Huang

et al. 2021

Front. Mater. Sci.

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Laser-synthesized TiN nanoparticles for biomedical applications: Evaluation of safety, biodistribution and pharmacokinetics

Cited by 60 publications

References 65 publications

Laser‐induced cavitation in plasmonic nanoparticle solutions: A comparative study between gold and titanium nitride

Laser‐induced cavitation in plasmonic nanoparticle solutions: A comparative study between gold and titanium nitride

Smart Electrospun Hybrid Nanofibers Functionalized with Ligand-Free Titanium Nitride (TiN) Nanoparticles for Tissue Engineering

Bibliometric landscape of the researches on protein corona of nanoparticles

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