Laser Treatment Monitoring with Reflectance Confocal Microscopy

Guida, Stefania; Longo, Caterina; Amato, Stefano; Rossi, Anthony; Manfredini, Marco; Ciardo, Silvana; Spadafora, Marco; Nisticò, Steven Paul; Mercuri, Santo Raffaele; Rongioletti, Franco; Zerbinati, Nicola; Pellacani, Giovanni

doi:10.3390/medicina59061039

Cited by 10 publications

(3 citation statements)

References 46 publications

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“…Nonetheless, in the era of innovative perioperative imaging methods in all subspecialties of surgery [ 24 , 25 ], we will continue to use ICGA in our clinical practice, as we believe it provides a more precise prediction of parathyroid gland-viability especially in patients undergoing central neck dissection. This valuable information aids in decision-making for parathyroid autotransplantation and will give us an idea of which patients might be susceptible to hypoparathyroidism.…”

Section: Discussionmentioning

confidence: 99%

Impact of Indocyanine Green Angiography on Postoperative Parathyroid Function: A Propensity Score Matching Study

Karahan,

Toprak,

Celik

et al. 2024

JCM

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Background: Thyroidectomy constitutes an important portion of endocrine surgery procedures and is associated with various complications such as bleeding, recurrent laryngeal nerve injury, and postoperative hypoparathyroidsm. Effective parathyroid preservation during thyroid surgery is crucial for patient well-being, with current strategies heavily reliant on surgeon experience. Among various methods, Indocyanine Green Angiography (ICGA) offers a promising method for intraoperative assessment of parathyroid gland perfusion. Methods: In a retrospective study, patients undergoing bilateral thyroidectomy from January 2021 to January 2023 were analyzed, excluding those with previous thyroidectomy, parathyroid disease, or chronic kidney disease. The study compared a control group (n = 175) with an ICGA group (n = 120), using propensity score matching for statistical analysis. Matched cohorts included 120 patients in each group. The primary outcome of this study was identified as temporary postoperative hypoparathyroidism, with secondary outcomes including the rate of parathyroid reimplantation and the incidence of permanent postoperative hypoparathyroidism. Results: The ICGA group showed significantly more parathyroid autotransplantations (p < 0.01). While not statistically significant, the control group had a higher incidence of temporary postoperative hypoparathyroidism (p < 0.09). Rates of hypocalcemia on postoperative day 1 and permanent hypocalcemia were similar. Subgroup analysis indicated more postoperative day 1 hypoparathyroidism in the control group during central neck dissections (p < 0.049). Conclusions: Intraoperative ICGA use correlated with higher parathyroid autotransplantation and suggested reduced postoperative hypoparathyroidism. Changes in fluorescence intensity following a second ICG injection may provide an objective method to assess parathyroid perfusion. Further large-scale studies are needed to fully understand ICGA’s impact on parathyroid preservation.

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Section: Discussionmentioning

confidence: 99%

Impact of Indocyanine Green Angiography on Postoperative Parathyroid Function: A Propensity Score Matching Study

Karahan,

Toprak,

Celik

et al. 2024

JCM

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“…Moreover, recent studies have highlighted the role of EVOO in enhancing skin repair mechanisms [ 29 , 30 , 31 ]. The topical application of EVOO has been shown to accelerate wound healing processes, attributing to the stimulation of collagen synthesis and angiogenesis.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the Impact of Oleocanthal and Oleacein on Skin Aging: Results of a Randomized Clinical Study

Nisticò,

Greco,

Amato

et al. 2024

Medicina

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The prevalence of skin aging and the request for effective treatments have driven dermatological research towards natural solutions. This study investigates the anti-aging efficacy of two bioactive natural polyphenols, Oleocanthal and Oleacein, in a skincare formulation. A single-blind, randomized clinical trial involved 70 participants, using a comprehensive exclusion criterion to ensure participant safety and study integrity. Participants applied the Oleocanthal and Oleacein 1% serum formulation twice daily for 30 days. The efficacy was objectively assessed using the VISIA® Skin Analysis System at baseline, after 15 days, and after 30 days. Results indicated significant wrinkle reduction in most groups. For women aged 45–79 years, the mean change was −33.91% (95% CI: −46.75% to −21.07%). For men aged 20–44 years, it was −51.93% (95% CI: −76.54% to −27.33%), and for men aged 45–79 years, it was −46.56% (95% CI: −58.32% to −34.81%). For women aged 20–44 years, the change was −25.68% (95% CI: −63.91% to 12.54%), not statistically significant. These findings highlight the potential of EVOO-derived polyphenols in anti-aging skincare, particularly for older adults. This research paves the way for further exploration into natural compounds in dermatology, particularly for aging skin management.

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“…The aim is to illuminate the benefits and practical applications of CO2 laser frenuloplasty, supported by a comprehensive evaluation of patient-reported outcomes. This includes a detailed analysis of its impact on both the physical and mental well-being of patients, contributing to a broader understanding of its role in modern surgical practice [15].…”

Section: Introductionmentioning

confidence: 99%

CO2 Laser Frenuloplasty: Advancing Minimally Invasive Techniques for Rapid Healing and Improved Patient Outcomes

Amato,

Nisticò,

Bennardo

et al. 2024

Surgeries

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This study explores the innovative use of CO2 laser technology in frenuloplasty, a significant shift from classic methods like scalpel surgery or electrocautery towards a minimally invasive approach. The research involved 15 patients aged 25 to 50, undergoing frenuloplasty with a CO2 laser system equipped with a 7-inch defocused handpiece, set at 20 Hz and 0.3 W. This method diverges from conventional laser techniques, focusing on controlled laser passes combined with manual traction to elongate the fibrous tissue of the frenulum. The results demonstrated that the CO2 laser technique allowed for a precise and progressive modification of the frenulum, significantly reducing the risks of hemorrhage and secondary intention fibrosis. The healing process was notably expedited, with patients reporting satisfactory outcomes within a two-week period. Statistically significant improvements were observed in patient-reported outcomes, as evidenced by the increases in the Short Form Health Survey (SF-12) scores, with the mean Physical Component Summary (PCS) score rising from 32.5 to 47.5 and the mean Mental Component Summary (MCS) score from 39.3 to 52.3 (p < 0.001 for both). The study concludes that CO2 laser frenuloplasty is an effective and safe technique, offering substantial benefits in terms of reduced healing time and enhanced patient satisfaction. The significant improvements in SF-12 scores underscore the positive impact on patient quality of life, advocating for the broader application of this technique in clinical practice. Further research is warranted to explore its potential in a wider clinical context.

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Laser Treatment Monitoring with Reflectance Confocal Microscopy

Cited by 10 publications

References 46 publications

Impact of Indocyanine Green Angiography on Postoperative Parathyroid Function: A Propensity Score Matching Study

Impact of Indocyanine Green Angiography on Postoperative Parathyroid Function: A Propensity Score Matching Study

Evaluating the Impact of Oleocanthal and Oleacein on Skin Aging: Results of a Randomized Clinical Study

CO2 Laser Frenuloplasty: Advancing Minimally Invasive Techniques for Rapid Healing and Improved Patient Outcomes

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