Laser treatment of synovial inflammatory process in experimentally induced microcrystalline arthritis in Wistar rats

Bartoli, Débora Mara Fortes; Felizatti, Airton Luiz; Bomfim, Fernando Russo Costa do; Bovo, Julia Leme; Aro, Andréa Aparecida de; Amaral, Maria Esméria Corezzola do; Esquisatto, Marcelo Augusto Marretto

doi:10.1007/s10103-020-03055-6

Cited by 3 publications

(3 citation statements)

References 51 publications

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“…Related to the synovial inflammatory process, a previous study conducted by our group using an induced arthritis model treated with PBM showed that at 7 days, the irradiated laser group had a similar number of granulocytes in relation to the induced and untreated group; these cells are related to the inflammatory process. 32 Our results for inflammatory regions showed an improvement in the morphological aspects with PRP and the laser. Both treatments were used in relation to Sham, and the best results were observed in both treatments.…”

Section: Discussionsupporting

confidence: 49%

Photobiomodulation (λ=808nm) and Platelet-Rich Plasma (PRP) for the Treatment of Acute Rheumatoid Arthritis in Wistar Rats

et al. 2021

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Introduction: Rheumatoid arthritis (RA) causes inflammation, pain, edema, and articular degradation and its treatment can be based on anti-inflammatory drugs, photobiomodulation (PBM) and/or platelet-rich plasma (PRP) that can decrease cell flow and promote local healing. In the present study, we evaluate the effects of PBM and PRP on acute arthritis in Wistar rats through inflammatory and oxidative stress parameters. Methods: Thirty female Wistar rats were assigned to five groups (n=6, each group): Control, Sham, PRP, Laser, and PRP+Laser. For arthritis induction, all animals of groups Sham, PRP, Laser and PRP+Laser received an intraarticular injection of Zymosan® (200µg) in the right knee. Twenty-four hours post-arthritis induction, PRP was prepared and injected (8 × 105 of platelets) in animals of PRP and PRP+Laser groups. PBM was performed in Laser and PRP+Laser groups by single-dose therapy with the GaAlAs laser (λ=808 nm, P=25 mW, fluence=30 J/cm2 , beam area=0.02 mm2 , t=33 seconds, E=0.825 J, punctual application). After seven days of induction, serum samples were collected and thiobarbituric acid reactive substances (TBARS), nitric oxide (NO) and catalase activity were analysed. Morphological parameters were measured for inflammation areas, cartilage thickness, and C3 protein expression in knee samples. Statistical analysis was performed with an ANOVA test and Tukey’s post-hoc test with a significance level of 5% (P<0.05). Results: NO was lower in the treated groups compared to the Sham group, and TBARS did not show any differences, while catalase showed greater activity between PRP+Laser versus PRP (P<0.05). Inflammatory areas and cartilage thickness were lower in the treated groups compared to Sham (P<0.05), while no differences in C3 protein expression was observed. Conclusion: PBM associated with PRP is better for anti-inflammatory and joint preservation by morphological aspects and NO levels that concern a potential clinical application.

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Section: Discussionsupporting

confidence: 49%

Photobiomodulation (λ=808nm) and Platelet-Rich Plasma (PRP) for the Treatment of Acute Rheumatoid Arthritis in Wistar Rats

et al. 2021

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“…TGF-β, produced by synovial fibroblasts, inhibits the production of TNF-α and other inflammatory factors [ 81 ]. Bartoli et al [ 82 ] reported increased TGF-β content in a Wistar mouse model of arthritis irradiated with 670 nm lasers. Overall, PBM plays a regulatory role in arthritis by reducing the production of pro-inflammatory cytokines and upregulating anti-inflammatory cytokines [ 83 ].…”

Section: The Mechanism Of Pbm On Arthritis Treatmentmentioning

confidence: 99%

“…Commonly measured mediators include MMP, IL cytokines, TNF-α, and VEGF. Several studies have reported significant decreases in the contents of PGE-2, TNF-α, MMP, IL-1, and IL-6 after PBM treatment in mice [ 67 , 69 , 71 , 72 , 76 , 82 , 110 , 133 , 139 ]. These changes result in the non-activation of response cells involved in arthritis, such as macrophages and lymphocytes that mediate the inflammatory response.…”

Section: Pbm Regulates Arthritis Animalsmentioning

confidence: 99%

The Mechanisms and Efficacy of Photobiomodulation Therapy for Arthritis: A Comprehensive Review

Zhang,

2023

IJMS

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Rheumatoid arthritis (RA) and osteoarthritis (OA) have a significant impact on the quality of life of patients around the world, causing significant pain and disability. Furthermore, the drugs used to treat these conditions frequently have side effects that add to the patient’s burden. Photobiomodulation (PBM) has emerged as a promising treatment approach in recent years. PBM effectively reduces inflammation by utilizing near-infrared light emitted by lasers or LEDs. In contrast to photothermal effects, PBM causes a photobiological response in cells, which regulates their functional response to light and reduces inflammation. PBM’s anti-inflammatory properties and beneficial effects in arthritis treatment have been reported in numerous studies, including animal experiments and clinical trials. PBM’s effectiveness in arthritis treatment has been extensively researched in arthritis-specific cells. Despite the positive results of PBM treatment, questions about specific parameters such as wavelength, dose, power density, irradiation time, and treatment site remain. The goal of this comprehensive review is to systematically summarize the mechanisms of PBM in arthritis treatment, the development of animal arthritis models, and the anti-inflammatory and joint function recovery effects seen in these models. The review also goes over the evaluation methods used in clinical trials. Overall, this review provides valuable insights for researchers investigating PBM treatment for arthritis, providing important references for parameters, model techniques, and evaluation methods in future studies.

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Unraveling the RAGE-NF-κB pathway: implications for modulating inflammation in diabetic neuropathy through photobiomodulation therapy

Ferreira,

Rocha,

Chacur

2024

Lasers Med Sci

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Laser treatment of synovial inflammatory process in experimentally induced microcrystalline arthritis in Wistar rats

Cited by 3 publications

References 51 publications

Photobiomodulation (λ=808nm) and Platelet-Rich Plasma (PRP) for the Treatment of Acute Rheumatoid Arthritis in Wistar Rats

Photobiomodulation (λ=808nm) and Platelet-Rich Plasma (PRP) for the Treatment of Acute Rheumatoid Arthritis in Wistar Rats

The Mechanisms and Efficacy of Photobiomodulation Therapy for Arthritis: A Comprehensive Review

Unraveling the RAGE-NF-κB pathway: implications for modulating inflammation in diabetic neuropathy through photobiomodulation therapy

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