Lasers and the treatment of periodontitis: the essence and the noise

Cobb, Charles M.

doi:10.1111/prd.12137

Cited by 82 publications

(87 citation statements)

References 336 publications

(926 reference statements)

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“…Laser therapy provided minimally invasive soft tissue and biostimulatory effects on tissue regeneration. 101,102 Laser therapy significantly improved clinical parameters, including the plaque index, gingival index, probing depth, clinical attachment level and BOP. 89 The biochemical parameters IL-1β and TNFα were reduced as well.…”

Section: Antibioticsmentioning

confidence: 97%

Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review

et al. 2020

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Interleukin(IL)-1β, a pro-inflammatory cytokine, was elevated and participates in periodontitis. Not only the link between IL-1β and periodontitis was proved by clinical evidence, but also the increased IL-1β triggers a series of inflammatory reactions and promotes bone resorption. Currently, IL-1β blockage has been therapeutic strategies for autoimmune and autoinflammatory diseases such as rheumatoid arthritis, cryopyrin-associated periodic syndromes, gout and type II diabetes mellitus. It is speculated that IL-1β be a potential therapeutic target for periodontitis. The review focuses on the production, mechanism, present treatments and future potential strategies for IL-1β in periodontitis.

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Section: Antibioticsmentioning

confidence: 97%

Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review

et al. 2020

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“…It is true that some adjunct therapies for periodontal disease in humans are available, including antibiotics and low-level laser treatment for antimicrobial and antibiofilm approaches, respectively (50,51). However, long-term use of antibiotics is known to develop antibiotic-resistant bacteria (52), while the laser may cause tissue damage (53).…”

Section: Discussionmentioning

confidence: 99%

OC‐STAMP promotes osteoclast fusion for pathogenic bone resorption in periodontitis via up‐regulation of permissive fusogen CD9

Ishii

Ruiz-Torruella²,

Ikeda³

et al. 2018

FASEB j.

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Cell fusion-mediated formation of multinuclear osteoclasts (OCs) plays a key role in bone resorption. It is reported that 2 unique OC-specific fusogens [ i.e., OC-stimulatory transmembrane protein (OC-STAMP) and dendritic cell-specific transmembrane protein (DC-STAMP)], and permissive fusogen CD9, are involved in OC fusion. In contrast to DC-STAMP-knockout (KO) mice, which show the osteopetrotic phenotype, OC-STAMP-KO mice show no difference in systemic bone mineral density. Nonetheless, according to the ligature-induced periodontitis model, significantly lower level of bone resorption was found in OC-STAMP-KO mice compared to WT mice. Anti-OC-STAMP-neutralizing mAb down-modulated in vitro: 1) the emergence of large multinuclear tartrate-resistant acid phosphatase-positive cells, 2) pit formation, and 3) mRNA and protein expression of CD9, but not DC-STAMP, in receptor activator of NF-κB ligand (RANKL)-stimulated OC precursor cells (OCps). While anti-DC-STAMP-mAb also down-regulated RANKL-induced osteoclastogenesis in vitro, it had no effect on CD9 expression. In our mouse model, systemic administration of anti-OC-STAMP-mAb suppressed the expression of CD9 mRNA, but not DC-STAMP mRNA, in periodontal tissue, along with diminished alveolar bone loss and reduced emergence of CD9 OCps and tartrate-resistant acid phosphatase-positive multinuclear OCs. The present study demonstrated that OC-STAMP partners CD9 to promote periodontal bone destruction by up-regulation of fusion during osteoclastogenesis, suggesting that anti-OC-STAMP-mAb may lead to the development of a novel therapeutic regimen for periodontitis.-Ishii, T., Ruiz-Torruella, M., Ikeda, A., Shindo, S., Movila, A., Mawardi, H., Albassam, A., Kayal, R. A., Al-Dharrab, A. A., Egashira, K., Wisitrasameewong, W., Yamamoto, K., Mira, A. I., Sueishi, K., Han, X., Taubman, M. A., Miyamoto, T., Kawai, T. OC-STAMP promotes osteoclast fusion for pathogenic bone resorption in periodontitis via up-regulation of permissive fusogen CD9.

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“…47 The evidence from a recent review on the use of lasers in the treatment of periodontitis remains conflicted and insufficient to suggest that the integration of a laser in a periodontal treatment protocol will provide antimicrobial and healing outcomes superior to those achieved by traditional therapy. 51 Further reading For further resources and reading material concerning periodontal care in general practice, see Box 1. The associations between periodontitis and general health should also be discussed to improve motivation.…”

Section: Overzealous Brushersmentioning

confidence: 99%

Periodontal care in general practice: 20 important FAQs - Part one

Wadia¹,

Chapple

2019

BDJ Team

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answers to common periodontal care questions facing dental professionals in general practice. 1: Does periodontitis affect quality of life? Periodontitis is a common, chronic, multifactorial, inflammatory condition affecting the supporting tissues of the teeth. It leads to the progressive destruction of the tooth supporting apparatus and eventual tooth loss. There is now overwhelming evidence that periodontitis has a negative impact on oral health-related quality of life. 1,2,3,4,5 Significant impacts have been shown in the functional, physical, social and psychological domains. Severe periodontitis appears to have a greater impact than mild to moderate periodontitis. 6,7,8 It is important to be aware of this impact when assessing patients in practice. Discussions might include psychological concerns, halitosis, pain, and poor aesthetics. The periodontal treatment plan should be based on both the needs diagnosed by the clinician but also those perceived by the patient. The latest 'Global burden of diseases, injuries and risk factors' study demonstrated that, from 354 diseases/ injuries measured across 195 countries, the greatest age-standardised prevalence of 'years lived with disease' in both 1990 and 2017 were oral disorders, headache disorders, and tuberculosis including latent tuberculosis. 9 The periodontal data were true for both males and females and, unlike caries where age-standardised percentage rates had decreased, in periodontal diseases rates had increased between 2007 and 2017. 9 2: What's the latest on the role of diabetes in periodontitis? Diabetes mellitus is a long-term condition characterised by an inability to control blood glucose levels due to an absolute or relative lack of the hormone insulin or a lack of cell responsivity to insulin (insulin resistance). 10 The majority of people with diabetes can be classified as having type 1 or type 2, with type 2 diabetes being eight to nine times more common than type 1. In the UK, there are at least 3.2 million CPD: ONE HOUR CPD questions This article has four CPD questions attached to it which will earn you one hour of verifiable CPD. To access the free BDA CPD hub, go to https://cpd.bda.org/ login/index.php

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Lasers and the treatment of periodontitis: the essence and the noise

Cited by 82 publications

References 336 publications

Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review

Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review

OC‐STAMP promotes osteoclast fusion for pathogenic bone resorption in periodontitis via up‐regulation of permissive fusogen CD9

Periodontal care in general practice: 20 important FAQs - Part one

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