Lasers for the prevention and treatment of hypertrophic scars: a review of the literature

Rosenthal, Amanda; Kolli, Hiren; Israilevich, Rachel; Moy, Ronald L.

doi:10.1080/14764172.2020.1783451

Cited by 3 publications

(3 citation statements)

References 74 publications

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“…And laser intervention can not only reduce telangiectasia, 31 but also promote the deposition of adipose tissue and correct anatomical aberrations through the thermally induced lysis of collagen, thereby promoting tissue remodeling. [32][33][34] In superficial IH with thickness >5mm, the mean A score of the laser group was also significantly higher than the mean AR score of the observation group (Wilcoxon rank sum test, P<0.05). But the average AR score of the laser group was only 2.59.…”

Section: Discussionmentioning

confidence: 85%

Sequelae After Involution of Superficial Infantile Hemangioma: Early Intervention with 595-nm Pulsed Laser Combined with 755-nm Long-Pulsed Alexandrite Laser versus Wait-and-See

Jiang¹,

Xu²,

Fang³

et al. 2021

CCID

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Section: Discussionmentioning

confidence: 85%

Sequelae After Involution of Superficial Infantile Hemangioma: Early Intervention with 595-nm Pulsed Laser Combined with 755-nm Long-Pulsed Alexandrite Laser versus Wait-and-See

Jiang¹,

Xu²,

Fang³

et al. 2021

CCID

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“…These types of lasers have been shown to be capable of producing more significant curative effects than non-ablative lasers and their use is associated with increased side effects. 5 As a popular kind of laser therapy, fractional CO 2 laser therapy has been proven to be safe and effective in the treatment of hypertrophic scars. 6 Its capacity to improve hypertrophic scars has been reported.…”

Section: Introductionmentioning

confidence: 99%

“…Ablative lasers mainly include carbon dioxide (CO 2 ) lasers and erbium‐doped yttrium aluminum garnet (Er:YAG) lasers. These types of lasers have been shown to be capable of producing more significant curative effects than non‐ablative lasers and their use is associated with increased side effects 5 . As a popular kind of laser therapy, fractional CO 2 laser therapy has been proven to be safe and effective in the treatment of hypertrophic scars 6 .…”

Section: Introductionmentioning

confidence: 99%

The efficacy and safety of low‐energy carbon dioxide fractional laser use in the treatment of early‐stage pediatric hypertrophic scars: A prospective, randomized, split‐scar study

Won

Chen

et al. 2021

Lasers Surg Med

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Background: Various laser therapies have been introduced in scar management. However, pain during treatment has limited the application of laser therapy in pediatrics.Objectives: To evaluate whether the use of the low-energy mode of a carbon dioxide (CO 2 ) laser improves hypertrophic scars in a pediatric population. Methods: This prospective, randomized, split-scar trial was designed to assess the safety and efficacy of low-energy CO 2 laser use. Patients aged <12 years with hypertrophic scars were enrolled. Each hypertrophic scar was equally divided into three parts: the two ends of each scar were randomly assigned to control and experimental groups, and the center portion was considered a transition zone and was not included in the analysis. A total of three laser treatments were performed at 1-month intervals. Scar scale scores 6 months after the final treatment was the primary outcome. Additionally, the Visual Analog Scale (VAS) was used to evaluate pain after each treatment. Results: Of the 23 patients enrolled, 20 completed the study. The total Patient and Observer Scar Assessment Scale (POSAS) score at the 6-month follow-up was significantly lower for the treated site (44.95 for the treated group vs. 64.85 for the control group, p < 0.0001). Both the patient and observer POSAS scores showed an obvious difference between the treated and control groups (19.95 vs. 29.95 for patient scores, respectively, p < 0.0001, and 26.00 vs. 34.90 for observer scores, respectively, p < 0.0001). All observer and patient scores describing pain, pruritus, color, stiffness, and thickness were statistically different and favored the treated site. No significant difference was found in patient score of irregularity. The average VAS therapeutic pain score was 3.5 ± 1.43 out of 10. Conclusions: Low-energy CO 2 fractional laser therapy improved hypertrophic scars in a pediatric population. Therefore, for children with hypertrophic scar, low-energy CO 2 laser with less procedure pain may be more appropriate.

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Lasers and Intense Pulsed Light for the Treatment of Pathological Scars: A Network Meta-Analysis

Liu

Fang

et al. 2022

Aesthetic Surgery Journal

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Background Laser and intense pulsed light (IPL) therapies have shown promising effect on pathological scars, but the comparative effectiveness of laser and IPL therapies has not yet been studied. Objectives The aim of this study was to compare and rank the efficacy of laser and IPL therapies to determine the most effective treatment method for pathological scars. Methods Relevant studies published up to February 2022 were identified by searching PubMed, Web of science, the Cochrane Library, CNKI, and Wanfang databases. We defined Vancouver Scar Scale (VSS) score as the primary outcome. Both frequentist and Bayesian approaches were used to perform a network meta-analysis (NMA). Results We included 25 trials with a total of 1688 participants. The SUCRA rankings for VSS score based on the Bayesian approach suggested IPL + CO₂ (96.43%) > PDL + 1064 nm Nd:YAG (86.21%) > PDL + CO₂ (82.15%) > CO₂ (58.97%) > 1064 nm Nd:YAG (57.03%) > PDL (52%) > 532nm Nd:YAG (33.28%) > Er:YAG + IPL (28.38%) > Er:YAG (26.56%) > IPL (15.03%) > Control (13.97%). The ranking results based on the frequentist approach were basically consistent with those based on frequentist approach. Conclusions The results of the NMA showed that the combination of IPL and CO₂ laser has the highest probability of being the most effective intervention. However, our conclusions must be interpreted with caution due to the relatively few evaluation indicators included in our study. Future well-designed randomized controlled trials with large sample sizes are required to confirm our conclusions.

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Lasers for the prevention and treatment of hypertrophic scars: a review of the literature

Cited by 3 publications

References 74 publications

Sequelae After Involution of Superficial Infantile Hemangioma: Early Intervention with 595-nm Pulsed Laser Combined with 755-nm Long-Pulsed Alexandrite Laser versus Wait-and-See

Sequelae After Involution of Superficial Infantile Hemangioma: Early Intervention with 595-nm Pulsed Laser Combined with 755-nm Long-Pulsed Alexandrite Laser versus Wait-and-See

The efficacy and safety of low‐energy carbon dioxide fractional laser use in the treatment of early‐stage pediatric hypertrophic scars: A prospective, randomized, split‐scar study

Lasers and Intense Pulsed Light for the Treatment of Pathological Scars: A Network Meta-Analysis

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