Lasia spinosa (L.) thw. attenuates chemically induced behavioral disorders in experimental and computational models

Reza, A. S. M. Ali; Sakib, Mahfuz Ahmed; Nasrin, Shamima; Khan, Jishan; Khan, Mohammad Firoz; Hossen, Md. Amjad; Ali, Daw M.; Haque, Dr Md Anwarul

doi:10.1016/j.heliyon.2023.e16754

Cited by 5 publications

(5 citation statements)

References 66 publications

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“…Several phytochemicals from C. ternatea, such as 9,9-dimethoxybicyclo[3. Additionally, the 9,9-Dimethoxybicyclo[3.3.1]nona-2,4-dione molecule is non-irritating to the eyes and has anti-inflammatory qualities (Reza et al, 2023). The stability of the complex is demonstrated by the MD simulation at 150 ns.…”

Section: Discussionmentioning

confidence: 99%

“…According to Ololade Zacchaeus et al (2021) , these chemicals isolated from black velvet Tamarind seed extract have therapeutic benefits, including treating eye conditions. Additionally, the 9,9-Dimethoxybicyclo[3.3.1]nona-2,4-dione molecule is non-irritating to the eyes and has anti-inflammatory qualities ( Reza et al, 2023 ). The stability of the complex is demonstrated by the MD simulation at 150 ns.…”

Section: Discussionmentioning

confidence: 99%

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Topical antifungal keratitis therapeutic potential of Clitoria ternatea Linn. flower extract: phytochemical profiling, in silico modelling, and in vitro biological activity assessment

Yolin Angel,

Jeyakumar,

Jasmin Suriya

et al. 2024

Front. Microbiol.

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IntroductionFungal keratitis (FK) poses a severe threat to vision, potentially leading to blindness if not promptly addressed. Clitoria ternatea flower extracts have a history of use in Ayurvedic and Indian traditional medicines, particularly for treating eye ailments. This study investigates the antifungal and antibiofilm effects of Clitoria ternatea flower extracts on the FK clinical isolate Coniochaeta hoffmannii. Structural details and key compound identification were analysed through FTIR and GC-MS.MethodsThe minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of Clitoria ternatea flower extracts were determined using broth dilution and well plate techniques. Biofilm inhibitory activity was assessed through microscopic evaluation, while anti-irritant and cytotoxic properties were evaluated using CAE-EI and MTT assays. Through GC-MS and FT-IR analysis the compounds dissolved in the extract and their functional group were studied, and their toxicity screening and pharmacokinetic prediction were conducted in silico. Subsequently, compounds with high corneal permeability were further identified, and molecular docking and simulation studies at 150 ns were used to investigate their interactions with fungal virulence factors and human inflammatory proteins.Results and DiscussionAt a concentration of 250 µg/mL, the Clitoria ternatea flower extract displayed effective biofilm inhibition. MIC and MFC values were determined as 500 and 1000 µg/mL, respectively. CAE-EI and MTT assays indicated no significant irritant and cytotoxic effects up to a concentration of 3 mg/mL. Compounds like 9,9-dimethoxybicyclo[3.3.1]nonane-2,4-dione showed high corneal permeability with strong and stable interactions with fungal virulence cellobiose dehydrogenase, endo β 1,4 xylanase, and glucanase, as well as corneal inflammation-associated human TNF-α and Interleukin IL-1b protein targets. The findings indicate that extracts from C. ternatea flowers could be formulated for an effective and safe alternative for developing new topical FK therapeutics.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Topical antifungal keratitis therapeutic potential of Clitoria ternatea Linn. flower extract: phytochemical profiling, in silico modelling, and in vitro biological activity assessment

Yolin Angel,

Jeyakumar,

Jasmin Suriya

et al. 2024

Front. Microbiol.

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“…High consumption of foods rich in polyphenols may have a significant impact on the prevention of noncommunicable diseases (NCDs), including cancer [ 51 ]. Evidence in this area has motivated researchers to examine antioxidants for the prevention and treatment of diseases and the maintenance of human health [ 52 , 53 ]. According to a study, certain flavonoids and their related polyphenols greatly enhanced phosphomolybdate scavenging activity [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Apoptosis-inducing anti-proliferative and quantitative phytochemical profiling with in silico study of antioxidant-rich Leea aequata L. leaves

Mostofa,

Reza,

Khan

et al. 2024

Heliyon

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“…The cumulative immobility time during the last 5 min was calculated using VisuTrack software (XR-VT; Xinruan Technology Company, Shanghai). The immobility time was defined as the time when there was no body movement and passive hanging [ 23 ]. Increases in immobility indicate an increase in depressed-like behavior [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

The gut microbiota regulates the depressive-type behaviors and inflammatory processes after severe burn injuries in mice

Chen,

Xie,

Tan

et al. 2024

Heliyon

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Lasia spinosa (L.) thw. attenuates chemically induced behavioral disorders in experimental and computational models

Cited by 5 publications

References 66 publications

Topical antifungal keratitis therapeutic potential of Clitoria ternatea Linn. flower extract: phytochemical profiling, in silico modelling, and in vitro biological activity assessment

Topical antifungal keratitis therapeutic potential of Clitoria ternatea Linn. flower extract: phytochemical profiling, in silico modelling, and in vitro biological activity assessment

Apoptosis-inducing anti-proliferative and quantitative phytochemical profiling with in silico study of antioxidant-rich Leea aequata L. leaves

The gut microbiota regulates the depressive-type behaviors and inflammatory processes after severe burn injuries in mice

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