Lasing from Micro- and Nano-Scale Photonic Disordered Structures for Biomedical Applications

Gayathri, R.; Suchand Sandeep, C. S.; Vijayan, C.; Murukeshan, V. M.

doi:10.3390/nano13172466

Cited by 9 publications

(2 citation statements)

References 158 publications

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“…Random lasing is an unconventional lasing method, which operate without the traditional mirror cavities and relies on multiple scattering in a disordered medium to amplify light [15][16][17][18] . Tissues, being a disordered medium is capable of light trapping and exhibit random lasing in the presence of an appropriate gain medium.…”

Section: Introductionmentioning

confidence: 99%

Tumour polyp detection using random lasing

Gayathri,

Suchand Sandeep,

Vijayan

et al. 2024

Biomedical Applications of Light Scattering XIV

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Tumors arise from the uncontrolled growth of cells and can be benign or cancerous. The size of the tumor is one of the key factors in assessing its malignancy potential. Generally, larger tumor polyp tends to have higher risk of developing into a cancer. Smaller polyps often start benign but some of it evolve over time to adenomatous or cancerous and extend to other parts of the body. To mitigate this risk, even smaller polyps are usually removed if found during screening. However, the detection of small polyps, especially flat or sessile types, remains a challenge. Advanced techniques are being developed to identify early-stage tumors by studying biomechanical, biochemical, and morphological changes. Tumor progression alters the viscoelasticity, local refractive index, and surface roughness, increasing tissue disorder both structurally and optically. This disorder can localize light through multiple scattering and can be utilized to provide cavity feedback for lasing emission called 'random lasing'. In this work, we simulate a tumor polyp growth in a phantom tissue impregnated with a gain medium and investigate the resulting random lasing emission. We find that the emission properties such as the intensity, lasing threshold, emission wavelength, and linewidth are all influenced by the presence of the polyp and this technique could precisely identify even polyps of size ~ millimeters. Overall, this research showcases the potential of random lasing to investigate disorder-induced changes for early and sensitive detection of tumor and identification of tissue abnormalities.

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Section: Introductionmentioning

confidence: 99%

Tumour polyp detection using random lasing

Gayathri,

Suchand Sandeep,

Vijayan

et al. 2024

Biomedical Applications of Light Scattering XIV

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“…The emission characteristics, such as lasing threshold, linewidth, peak position, and intensity, are highly sensitive to changes in the disorder [4,5]. Random lasing thus has the potential to offer insights into the scattering dynamics and light propagation in disordered media such as biological tissues [6].…”

Section: Introductionmentioning

confidence: 99%

Random Lasing for Bimodal Imaging and Detection of Tumor

Gayathri,

Suchand Sandeep,

Vijayan

et al. 2023

Biosensors

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The interaction of light with biological tissues is an intriguing area of research that has led to the development of numerous techniques and technologies. The randomness inherent in biological tissues can trap light through multiple scattering events and provide optical feedback to generate random lasing emission. The emerging random lasing signals carry sensitive information about the scattering dynamics of the medium, which can help in identifying abnormalities in tissues, while simultaneously functioning as an illumination source for imaging. The early detection and imaging of tumor regions are crucial for the successful treatment of cancer, which is one of the major causes of mortality worldwide. In this paper, a bimodal spectroscopic and imaging system, capable of identifying and imaging tumor polyps as small as 1 mm2, is proposed and illustrated using a phantom sample for the early diagnosis of tumor growth. The far-field imaging capabilities of the developed system can enable non-contact in vivo inspections. The integration of random lasing principles with sensing and imaging modalities has the potential to provide an efficient, minimally invasive, and cost-effective means of early detection and treatment of various diseases, including cancer.

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One‐Step Fabrication of Carbon Dot‐Based Nanocomposites Powering Solid‐State Random Lasing

Stagi,

Carboni,

Anedda

et al. 2024

Small Structures

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Carbon dots (CDs) have attracted much attention for applications in photonics and optoelectronics because of their high emission efficiency and ease of synthesis. Although studies in solution are well established, solid‐state applications are less common because of optical quenching phenomena that critically affect CDs. Herein, the synthesis of amorphous CDs from citric acid, operating as hosts of dye molecules, and their incorporation into organic–inorganic silica matrices through a fast photo‐induced polymerization process are reported. The photocurable sol composition allows easy dispersion of nanometer‐sized scattering centers, such as titania or gold nanoparticles (NPs), which have been incorporated, along with CDs, into nanocomposites. The combination of high‐brightness CDs and nanoscatterers in the hybrid matrices allows for achieving and investigating the random lasing processes occurring in the orange‐red range of the visible spectrum. In situ‐grown gold NPs contribute to a significant improvement in solid‐state lasing, enabling an emission as narrow as 5 nm and a laser threshold as low as 0.3 mJ pulse−1. The present approach reveals the technological and scientific potential of CDs when embedded in solid‐state disordered active media.

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Lasing from Micro- and Nano-Scale Photonic Disordered Structures for Biomedical Applications

Cited by 9 publications

References 158 publications

Tumour polyp detection using random lasing

Tumour polyp detection using random lasing

Random Lasing for Bimodal Imaging and Detection of Tumor

One‐Step Fabrication of Carbon Dot‐Based Nanocomposites Powering Solid‐State Random Lasing

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