Lasing within Live Cells Containing Intracellular Optical Microresonators for Barcode-Type Cell Tagging and Tracking

Schubert, Marcel; Steude, Anja; Liehm, Philipp; Kronenberg, Nils M.; Karl, Markus; Campbell, Elaine C.; Powis, Simon J.; Gather, Malte C.

doi:10.1021/acs.nanolett.5b02491

Cited by 176 publications

(209 citation statements)

References 33 publications

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“…2017, 5, 1601022 www.advancedsciencenews.com droplet lasers based on polystyrene cavities. [8] With Q factors of lasing modes as high as ≈3 × 10 3 , these lasers have potential for future ultrahigh-sensitive sensors. BSA microlasers were found to be resistant to the aqueous environment of cell culture media and biocompatible to cell growth.…”

Section: Wwwadvopticalmatdementioning

confidence: 99%

“…[5,6] WGM lasers have been recently integrated to living cells for intracellular sensing and cell tracking, which opens a new frontier of biotechnology. [7,8] WGM lasers made of polymers of biological origin are of interest for biosensing. To date, various biolasers have been investigated using random cavity, [9][10][11][12][13] distributed feedback, [14][15][16] Fabry-Perot (F-P), [17][18][19] and WGM capillary tube.…”

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confidence: 99%

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Microsphere Solid‐State Biolasers

Caixeiro

Fernandes

et al. 2017

Advanced Optical Materials

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Biolasers obtained from biomaterials are attracting a wealth of interest for their potential as future biosensors with enhanced sensitivity, and advanced cell tracking. Here, miniature biolasers are reported, which are formed by bovine serum albumin (BSA) protein and biosourced polysaccharides derived from land plants such as cellulose and pectin. Using a green processing route aided by simple emulsions, solid-state microspheres with diameters of 15–100 µm are fabricated and utilized as whispering gallery mode lasers with thresholds of a few µJ mm–2 and quality factors of up to 3000. Furthermore, BSA microlasers are found to be compatible with cell growth and resistant to the aqueous environment of cell culture media. This environmentally friendly and biocompatible design shows promise for future implantable biosensing devices opening a path between laser science and medicine

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Section: Wwwadvopticalmatdementioning

confidence: 99%

mentioning

confidence: 99%

Microsphere Solid‐State Biolasers

Caixeiro

Fernandes

et al. 2017

Advanced Optical Materials

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“…9a, b) [47,162,163]. The WGM output spectra allowed the individual bead diameters to be determined with 50-pm precision, which can be used as a unique identifier to tag a large number of cells and track them.…”

Section: Cell Lasersmentioning

confidence: 99%

Toward biomaterial-based implantable photonic devices

et al. 2017

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Optical technologies are essential for the rapid and efficient delivery of health care to patients. Efforts have begun to implement these technologies in miniature devices that are implantable in patients for continuous or chronic uses. In this review, we discuss guidelines for biomaterials suitable for use in vivo. Basic optical functions such as focusing, reflection, and diffraction have been realized with biopolymers. Biocompatible optical fibers can deliver sensing or therapeutic-inducing light into tissues and enable optical communications with implanted photonic devices. Wirelessly powered, light-emitting diodes (LEDs) and miniature lasers made of biocompatible materials may offer new approaches in optical sensing and therapy. Advances in biotechnologies, such as optogenetics, enable more sophisticated photonic devices with a high level of integration with neurological or physiological circuits. With further innovations and translational development, implantable photonic devices offer a pathway to improve health monitoring, diagnostics, and light-activated therapies.

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“…Droplets which would not normally lase can be made to do so by introducing the fat droplets ('Intralipid'). This work, along with follow-up work [87], make claim to be the first to make use of biological material within the laser droplet, and the suggestion is that this technique could then be used to enhance detection capability for materials such as biocolloids and biomolecules, as well as be useful in probing biological properties in vivo, work which would not be realised for a further 20 years [88,89]. Work by the same group also explored other biomolecules, such as vitamin B2 [90] (and vitamin A by others [91]), demonstrating lasing of a material in which no bulk material laser observation had been made.…”

Section: Fluorescent Dyesmentioning

confidence: 99%

Droplet lasers: a review of current progress

McGloin

2017

Rep. Prog. Phys.

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Abstract. It is perhaps surprising that something as fragile as a microscopic droplet could possibly form a laser. In this article we will review some of the underpinning physics as to how this might be possible, and then examine the state of the art in the field. The technology to create and manipulate droplets will be examined, as will the different classes of droplet lasers. We discuss the rapidly developing fields of droplet biolasers, liquid crystal laser droplets and explore how droplet lasers could give rise to new bio and chemical sensing and analysis. The challenges that droplet lasers face in becoming robust devices, either as sensors or as photonic components in lab on a chip devices is assessed.

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Lasing within Live Cells Containing Intracellular Optical Microresonators for Barcode-Type Cell Tagging and Tracking

Cited by 176 publications

References 33 publications

Microsphere Solid‐State Biolasers

Microsphere Solid‐State Biolasers

Toward biomaterial-based implantable photonic devices

Droplet lasers: a review of current progress

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