Lassa Virus Seroprevalence in Sibirilia Commune, Bougouni District, Southern Mali

Abstract

The high rate documented in this study highlights the need for increased surveillance. Lassa Virus Seroprevalence, Mali

Annual Incidence of Lassa Virus Infection in Southern Mali

“…In Banzana, where rodent prevalence rates were relatively low, 14.5% of study participants had detectable IgG antibodies against LASV, whereas in Soromba and Bamba, where up to 50% of sampled rodents had evidence of LASV infection, 41% and 44% of volunteers, respectively, were seropositive for LASV. 12 These findings confirmed a large proportion of people in this region have been previously exposed to LASV. To ascertain the annual incidence of LASV infections in these villages, we returned in February 2016 to collect and serologically analyze blood samples from the same individuals.…”

“…12,13 The results of the 2015 serosurvey demonstrated that village-specific prevalence rates in humans correlated with infection rates previously observed in rodent populations. In Banzana, where rodent prevalence rates were relatively low, 14.5% of study participants had detectable IgG antibodies against LASV, whereas in Soromba and Bamba, where up to 50% of sampled rodents had evidence of LASV infection, 41% and 44% of volunteers, respectively, were seropositive for LASV.…”

“…Written consent, enrollment, physical assessment, and blood sample collection into ethylenediaminetetraacetic acid-treated microtubes via finger prick was identical to our previous study. 12 Plasma was separated on site and immediately preserved in liquid nitrogen. At the conclusion of sample collection in the third village, samples were transported to a laboratory in Bamako for serological testing using the same methods as the year before.…”

“…Plasma samples were tested for IgG antibodies reactive against LASV using a recombinant nucleocapsid-based enzyme-linked immunosorbent assay (ReLASV ® , Corgenix Medical Corporation, Inc., Broomfield, CO) as previously described. 12 The kits are produced under Corgenix Quality System and have been thoroughly evaluated for the detection of anti-LASV antibodies in patients at the Lassa fever ward of the Kenema Government Hospital in Sierra Leone (Branco, Boisen unpublished data). The 532 samples were initially screened at a 1:100 dilution.…”

Lassa fever infection from West Africa, dynamic and epidemiology of the virus on the population 1969–2019: a systematic review and meta-analysis

“…Human infectious diseases are a significant threat to global human health and with the majority of infectious diseases having a zoonotic. Recent investigations have found that LF is more widely distributed throughout the Wooded Savanna in West Africa [27]. In contrary to the study carried out by Richmond, Baglole [52], which is showed that LF was abundant in urban areas to poor sanitation and overcrowding.…”