2017
DOI: 10.1097/fbp.0000000000000267
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LASSBio-1422: a new molecular scaffold with efficacy in animal models of schizophrenia and disorders of attention and cognition

Abstract: Aiming to identify new antipsychotic lead-compounds, our group has been working on the design and synthesis of new N-phenylpiperazine derivatives. Here, we characterized LASSBio-1422 as a pharmacological prototype of this chemical series. Adult male Wistar rats and CF1 mice were used for in-vitro and in-vivo assays, respectively. LASSBio-1422 [1 and 5 mg/kg, postoperatively (p.o.)] inhibited apomorphine-induced climbing as well as ketamine-induced hyperlocomotion (1 and 5 mg/kg, p.o.), animal models predictive… Show more

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Cited by 10 publications
(2 citation statements)
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“…In another study, clozapine and LASSBio-1422 reversed the deficit only at the lowest pre-pulse stimulus while haloperidol was ineffective at all pre-pulse intensities. This model can be used to identify anti-serotoninergic activity of the test drug [20,23].…”
Section: Pre-pulse Inhibition (Ppi)mentioning
confidence: 99%
“…In another study, clozapine and LASSBio-1422 reversed the deficit only at the lowest pre-pulse stimulus while haloperidol was ineffective at all pre-pulse intensities. This model can be used to identify anti-serotoninergic activity of the test drug [20,23].…”
Section: Pre-pulse Inhibition (Ppi)mentioning
confidence: 99%
“…Administration of DOI induces head-twitch response (HTR), resembling positive schizophrenia symptoms (particularly hallucinations), and this effect is blocked by antipsychotic agents [ 34 ]. Moreover, DOI disrupts PPI [ 35 , 36 ], however, without changes in locomotor activity [ 37 ]. On a molecular level, DOI induces an increase in the frequency of spontaneous excitatory postsynaptic currents (sEPSCs) in pyramidal neurons [ 38 , 39 ].…”
Section: Pharmacological Modelsmentioning
confidence: 99%