Lasting anxiogenic effects of feline predator stress in mice: Sex differences in vulnerability to stress and predicting severity of anxiogenic response from the stress experience

Adamec, Robert E.; Head, David; Blundell, Jacqueline; Burton, Paul; Berton, Olivier

doi:10.1016/j.physbeh.2006.03.005

Cited by 140 publications

(97 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rats exposed to 7 days of unpredictable stress and tested 7 days later in the elevated plus-maze or a novel environment showed increased anxiety-like behaviors [13]. Single or multiple experiences of exposure to a predator, predator odor or social defeat augmented anxiogenic responses in rodents when tested 1 to 21 days following the exposure episode [1,2,4,5,7,8,11,45]. The sustained effects of predator stress have been reported in several unconditioned response tasks, including the elevated plusmaze and light-dark box [1][2][3]5,8].…”

Section: Discussionmentioning

confidence: 95%

“…Single or multiple experiences of exposure to a predator, predator odor or social defeat augmented anxiogenic responses in rodents when tested 1 to 21 days following the exposure episode [1,2,4,5,7,8,11,45]. The sustained effects of predator stress have been reported in several unconditioned response tasks, including the elevated plusmaze and light-dark box [1][2][3]5,8]. Similarly, a single session of foot shocks increased immobility and freezing behaviors in a novel environment when assessed 1-4 weeks after the stress exposure [54][55][56].…”

Section: Discussionmentioning

confidence: 96%

“…Unfortunately, the same rats were not tested in both of the unconditioned response tests. Several studies have used factor analysis to identify the dependent measures assessed in unconditioned response tasks that contribute to specific behavioral components, such as anxiety, locomotion, reactivity, and exploration [1,9,12,18,43,60]. The papers assessing 2 or more behavioral tasks tended only to find significant correlations between parameters on 2 tasks if the rat was genetically engineered for increased anxiety [15,18,40].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

The delayed effects of chronic unpredictable stress on anxiety measures

Matuszewich

Karney

Carter

et al. 2007

Physiology & Behavior

View full text Add to dashboard Cite

Previous research has found that exposure to unpredictable stress can augment anxiety in humans and animals. The appearance of anxiety symptoms in humans frequently develop after stress exposure has terminated, but few rodent studies have systematically examined the delayed anxiogenic effects of unpredictable stress. Therefore, the current study investigated whether anxiety-like behaviors in rats would increase at several time intervals following exposure to chronic unpredictable stress (CUS). Unconditioned and conditioned response tasks were used to assess anxiety in male rats 1, 7 or 14 days following exposure to 10 days of a variety of stressors. Rats exposed to CUS showed increased burying behaviors and immobility during the defensive burying test, a conditioned anxiety test. The effects on burying behavior were apparent 7 and 14 days after the termination of the unpredictable stress procedure, but not when tested 1 day after CUS. Total time immobile in the defensive burying test also increased 14 days after termination of the last stressor. In contrast, there were no significant effects of CUS on behavioral measures in the unconditioned response tasks, the elevated plus-maze or light-dark box, at any time point following exposure to CUS. The current findings suggest that CUS may be a useful model of human conditioned anxiety that develops subsequent to chronic stress exposure.

show abstract

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The delayed effects of chronic unpredictable stress on anxiety measures

Matuszewich

Karney

Carter

et al. 2007

Physiology & Behavior

View full text Add to dashboard Cite

show abstract

“…Whether such sensitizing actions take place with predator odors alone has not been investigated extensively, although some reports with cat odor (Adamec et al, 2006) and our work with ferret odor (Masini et al, 2006a) suggest that this might be the case. For instance, a single exposure to ferret odor led to higher plasma corticosterone and ACTH release in response to an additional 30 min exposure to ferret odor 11 days later, compared to a group of rats exposed to ferret odor for the first time and another group of rats repeatedly exposed (seven daily sessions of 30 min each) to ferret odor (Masini et al, 2006a).…”

Section: Subacute and Chronic Effects Of Ferret Odor On Neuroendocrinmentioning

confidence: 87%

Acute and chronic effects of ferret odor exposure in Sprague–Dawley rats

Campeau

Nyhuis

Sasse

et al. 2008

Neuroscience & Biobehavioral Reviews

View full text Add to dashboard Cite

This manuscript describes several behavioral and functional studies evaluating the capacity of ferret odors to elicit a number of acute and long-term responses in male Sprague-Dawley rats. Acute presentation elicits multiple responses, suggesting that ferret odor, likely from skin gland secretions, provides an anxiogenic-like stimulus in this strain of rats. Compared to cat odor, however, ferret odor did not produce rapid fear conditioning, a result perhaps attributable to methodological factors. Inactivation of the olfactory system and medial nucleus of the amygdala, combined with induction of the immediate-early gene c-fos, suggest the necessity of the accessory olfactory system in mediating the effects of ferret odor. Repeated exposures to ferret odor produce variable habituation of neuroendocrine and behavioral responses, perhaps indicative of the lack of control over the exact individual origin or concentration of ferret odor. Ferret odor induces rapid and long-term body weight regulation, thymic involution, adrenal hyperplasia and facilitation of the neuroendocrine response to additional challenges. It is argued that the use of such odors is exquisitely suited to investigate the brain regions coordinating anxiety-like responses and the long-term changes elicited by such stimuli.

show abstract

“…Female mice seem to be more negatively susceptible to stress-causing factors 26 . Lin et al 27 verified an anxiety effect in female mice submitted to EE and depressive behavior due to longer immobility time on the forced swim test.…”

mentioning

confidence: 98%

The influence of enriched environment on spatial memory in Swiss mice of different ages

Druzian

Melo

Souza

2015

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

The objective of this study was to evaluate the influence of enriched environment on spatial memory acquisition in mice of three different age groups. Weanling, young, and young adult female Swiss mice were housed in a standard control or enriched environment for 50 days, and their spatial memory was tested with the Morris Water Maze. We did not observe an experimental effect for spatial memory acquisition, and there was neither an effect of time of analysis nor an interaction between experimental group and time of analysis. Regarding effects of experimental group and training day in relation to latency in finding the hidden platform, we did find an effect in the experimental young adult mice group (p = 0.027), but there was no interaction between these factors in all three groups. Based on these findings environmental enrichment did not enhance spatial memory acquisition in female Swiss mice in the tested age groups.

show abstract

Lasting anxiogenic effects of feline predator stress in mice: Sex differences in vulnerability to stress and predicting severity of anxiogenic response from the stress experience

Cited by 140 publications

References 66 publications

The delayed effects of chronic unpredictable stress on anxiety measures

The delayed effects of chronic unpredictable stress on anxiety measures

Acute and chronic effects of ferret odor exposure in Sprague–Dawley rats

The influence of enriched environment on spatial memory in Swiss mice of different ages

Contact Info

Product

Resources

About