Lasting effects of early chronic caffeine feeding on rats' behavior and brain in later life

Nakamoto, Tetsuo; Roy, G.L.; Gottschalk, Sheila; Yazdani, Malektaj; Rossowska, M

doi:10.1016/0031-9384(91)90309-c

Cited by 30 publications

(14 citation statements)

References 34 publications

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“…We have confirmed that early exposure to caffeine leads to altered motor behavior, including enhanced responses to cocaine [9], [14], [17], [18], [19]. It is recognized that low doses of cocaine and caffeine produce additive effects [20], [21].…”

Section: Discussionsupporting

confidence: 72%

Perinatal Caffeine, Acting on Maternal Adenosine A1 Receptors, Causes Long-Lasting Behavioral Changes in Mouse Offspring

et al. 2008

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BackgroundThere are lingering concerns about caffeine consumption during pregnancy or the early postnatal period, partly because there may be long-lasting behavioral changes after caffeine exposure early in life.Methodology/Principal FindingsWe show that pregnant wild type (WT) mice given modest doses of caffeine (0.3 g/l in drinking water) gave birth to offspring that as adults exhibited increased locomotor activity in an open field. The offspring also responded to cocaine challenge with greater locomotor activity than mice not perinatally exposed to caffeine. We performed the same behavioral experiments on mice heterozygous for adenosine A1 receptor gene (A1RHz). In these mice signaling via adenosine A1 receptors is reduced to about the same degree as after modest consumption of caffeine. A1RHz mice had a behavioral profile similar to WT mice perinatally exposed to caffeine. Furthermore, it appeared that the mother's genotype, not offspring's, was critical for behavioral changes in adult offspring. Thus, if the mother partially lacked A1 receptors the offspring displayed more hyperactivity and responded more strongly to cocaine stimulation as adults than did mice of a WT mother, regardless of their genotype. This indicates that long-term behavioral alterations in the offspring result from the maternal effect of caffeine, and not a direct effect on fetus. WT offspring from WT mother but having a A1R Hz grandmother preserved higher locomotor response to cocaine.Conclusions/SignificanceWe suggest that perinatal caffeine, by acting on adenosine A1 receptors in the mother, causes long-lasting behavioral changes in the offspring that even manifest themselves in the second generation.

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Section: Discussionsupporting

confidence: 72%

Perinatal Caffeine, Acting on Maternal Adenosine A1 Receptors, Causes Long-Lasting Behavioral Changes in Mouse Offspring

et al. 2008

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“…Postnatal coffee ingestion has been shown to influence brain function and brain chemistry in rodents [6,7]. Caffeine and the xanthines in coffee have been associated with greater reactivity and timidity in rodents and in humans [8], but these effects are much clearer in studies with rodents, when much higher dosages are administered [9].…”

Section: Introductionmentioning

confidence: 99%

Effects of discontinuing coffee intake on iron deficient Guatemalan toddlers' cognitive development and sleep

Engle

VasDias

Howard³

et al. 1999

Early Human Development

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Coffee is commonly given daily to toddlers in Guatemala. Possible negative effects of coffee ingestion on cognitive development and sleep patterns were assessed in 132 children 12-24 months of age who had received coffee for . 2 months and were iron deficient on at least one indicator. Children were stratified by initial hemoglobin (A 5 anemic, Hgb , 10.5 g / dl; NA 5 'non-anemic', Hgb $ 10.5 g / dl) and were randomly assigned to an experimental group treatment on test scores or BRS ratings were found. In the 24 h period reported on at the final visit, children in the Substitute group slept more during the night and overall (night plus naps) than children in the Coffee group, a difference not found at the first visit. No differences were (S 5 substitute consisting of sugar and coloring), and a control group (C 5 continuation of coffee) (42 C-NA; 53 S-NA; 18 C-A; and 19 S-A). Anemic children were provided Fe supplements for 2-3 months. Compliance was assessed every 2 weeks. After 5 months, testers masked to treatment group and anemia evaluated children with the Bayley Scales of Infant Development II in a central location. Scores were the Mental Development Index (MDI), the Psychomotor Development Index (PDI), and scales from the Behavior Rating Scale (BRS). The child's sleep in the previous 24 h was assessed with a set of standardized sleep questions to the care giver on the first visit and every 2 weeks thereafter. No significant effects of found in sleep difficulty or number of times waking at night. Women's reported coffee intake per day during pregnancy was associated with lower BRS ratings, even after controlling for SES and child age. The effects of postnatal coffee ingestion in Guatemala were seen for sleep duration, but not for cognitive development. Prenatal coffee ingestion was negatively associated with Behavior Rating Scales and should be investigated further.

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“…These effects on the cerebellum could possibly cause abnormal development in the newborn brain and may not manifest themselves in the neonate, but may manifest themselves later in life as demonstrated in the permanent hyperactivity of the certain group of rats exposed to caffeine [23]. The present study strongly suggests that early exposure of suckling offspring to caffeine could impair the normal development of the cerebellum changing the profiles of LCSFA and LCMUFA.…”

Section: Discussionmentioning

confidence: 66%

Effects of Caffeine on the Saturated and Monounsaturated Fatty Acids of the Newborn Rat Cerebellum

et al. 2004

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Caffeine (1,3,7-trimethylxanthine) is one of the most commonly consumed drugs in our daily life, and its use is increasing. However, very little attention has been paid to its potential effects on early growth and development. Because of the steady increase in breast feeding of infants and because caffeine diffuses readily into breast milk, the present study examined if caffeine intake by newborn rats during lactation would affect the saturated and monounsaturated fatty acids in the growing cerebellum. A total of 10 timed pregnant rats were purchased from the breeder. At birth litters were combined, and 8 pups were randomly assigned to each dam without regard to the sex of the pups. Dams with litters were divided into 2 groups. Dams of group 1 received a 20% protein diet as a control, and dams of group 2 received a 20% protein diet plus caffeine (4 mg/100 g BW). Pups were killed at day 10. The cerebellums were removed, weighed and homogenized. Gas chromatograph-mass spectrometry was used to identify and quantify free fatty acids. Chronic caffeine exposure from birth to day 10 in pups through the maternal milk resulted in a decrease in cerebellum weight, a significant increase in the saturated fatty acids, and a tendency toward an increase of monounsaturated fatty acids. In addition, there was a slight increase of some of the polyunsaturated fatty acids. However, there was no difference in food intake of the lactating dams and weight gain of the pups between the groups. These data indicate that early caffeine intake by the suckling pups alters the composition of fatty acids of the cerebellum; thus, avoidance of caffeine during lactation is critical. The risks and benefits of caffeine administration in premature infants must be carefully evaluated during this rapid period of brain growth.

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Lasting effects of early chronic caffeine feeding on rats' behavior and brain in later life

Cited by 30 publications

References 34 publications

Perinatal Caffeine, Acting on Maternal Adenosine A1 Receptors, Causes Long-Lasting Behavioral Changes in Mouse Offspring

Perinatal Caffeine, Acting on Maternal Adenosine A1 Receptors, Causes Long-Lasting Behavioral Changes in Mouse Offspring

Effects of discontinuing coffee intake on iron deficient Guatemalan toddlers' cognitive development and sleep

Effects of Caffeine on the Saturated and Monounsaturated Fatty Acids of the Newborn Rat Cerebellum

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