2023
DOI: 10.1007/s00535-023-01960-5
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LAT1 expression influences Paneth cell number and tumor development in ApcMin/+ mice

Abstract: Background Amino acid transporters play an important role in supplying nutrition to cells and are associated with cell proliferation. L-type amino acid transporter 1 (LAT1) is highly expressed in many types of cancers and promotes tumor growth; however, how LAT1 affects tumor development is not fully understood. Methods To investigate the role of LAT1 in intestinal tumorigenesis, mice carrying LAT1 floxed alleles that also expressed Cre recombinase from th… Show more

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“… 21 Due to the mutation in multiple intestinal neoplasia, Apc Min/+ mice spontaneously develop multiple adenomatous polyps in the small intestine and fewer polyps in the colon. 22 , 23 Therefore, Apc Min/+ mice remain a classic mouse model for studying human intestinal tumorigenesis. 24 , 25 , 26 , 27 The Apc Min/+ ; Mogat2 −/− mice model was established to investigate the effect of Mogat2 on spontaneous intestinal adenocarcinoma in mice with an APC mutation.…”
Section: Discussionmentioning
confidence: 99%
“… 21 Due to the mutation in multiple intestinal neoplasia, Apc Min/+ mice spontaneously develop multiple adenomatous polyps in the small intestine and fewer polyps in the colon. 22 , 23 Therefore, Apc Min/+ mice remain a classic mouse model for studying human intestinal tumorigenesis. 24 , 25 , 26 , 27 The Apc Min/+ ; Mogat2 −/− mice model was established to investigate the effect of Mogat2 on spontaneous intestinal adenocarcinoma in mice with an APC mutation.…”
Section: Discussionmentioning
confidence: 99%