Latanoprost-Induced Stabilization of Central Visual Function in Patients with Primary Open-Angle Glaucoma

Evans, David W.; Bartlett, Jimmy D.; Houde, Barbara; Than, Tammy; Shaikh, Adam

doi:10.1089/jop.2007.0106

Cited by 5 publications

(6 citation statements)

References 13 publications

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“…The average age of our study population was 60 years (SD 12.31, range 26-84 years) which was similar to the study done by Evans and coworkers where the average age group of patients receiving latanoprost was also 60 years (SD 8.9) [9]. In our study, the average age was relatively more than the age of patients studied by Richman et al (age 57 years) [18] and Arend et al (age 55 years) [8].…”

Section: Discussionsupporting

confidence: 87%

“…Evans et al studied the change in CS in glaucoma patients already on beta blockers. They experienced an improvement in CS at 3 cycles per degree (cpd) (p = 0.03) on shifting to latanoprost possibly due to its effects on optic nerve and macular circulation [9]. All studies which evaluated change in visual function following treatment ascertained changes only in central CS, but peripheral CS was not assessed.…”

Section: Introductionmentioning

confidence: 99%

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Analysing the change in contrast sensitivity post-travoprost treatment in primary open-angle glaucoma patients using Spaeth Richman contrast sensitivity test

et al. 2022

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glaucoma group was 72.05 ± 9.87, in the moderate glaucoma group, it was 62.23 ± 9.2, and in the severe glaucoma group, it was 59.36 ± 11.65. After 6 months of treatment with travoprost, the CS improved to 76.05 ± 8.36 in mild group, 76.69 ± 8.82 in moderate group and 67.18 ± 11.15 in severe group (p value: 0.014). The percentage change in the CS from baseline showed significant improvement in the superotemporal quadrant at 1 month (p value: 0.032), superonasal quadrant (p value: 0.049), inferotemporal quadrant at 3 months (p value: 0.003) and 6 months (p value: 0.039). Inferonasal quadrant was affected most by glaucoma. A statistically significant correlation was seen between total SPARCS score with MD and PSD. Correlation was also seen between the percentage change in CS and average RNFL thickness at 3 and 6 months. Conclusion Both central and peripheral CS improve following IOP reduction with travoprost. Change in the CS has a significant correlation with RNFL thickness and the perimetric indices.

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Section: Discussionsupporting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Analysing the change in contrast sensitivity post-travoprost treatment in primary open-angle glaucoma patients using Spaeth Richman contrast sensitivity test

et al. 2022

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“…All the included eyes were under treatment. Given reports on partial reversibility of CS loss in patients after treatment, 47–49 it is not clear how this might have affected the findings.…”

Section: Discussionmentioning

confidence: 95%

Association of Structural and Functional Measures With Contrast Sensitivity in Glaucoma

Fatehi

Nowroozizadeh

Henry

et al. 2017

American Journal of Ophthalmology

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PURPOSE To test the hypothesis that structural and functional measures predict contrast sensitivity (CS) outcomes in glaucomatous eyes. DESIGN Cross-sectional prospective study. METHODS 105 eyes of 65 patients who underwent macular SD-OCT imaging, 24-2 standard achromatic visual fields (VF) and CS measurement on the same day were enrolled. Association of CS at 4 spatial frequencies (3, 6, 12 and 18 cycles per degree, cpd), with structural and functional outcomes was explored with correlation and regression analyses. RESULTS The median (IQR) 24-2 visual field mean deviation was −7.6 (−11.1 to −3.0). Significant correlations were found between CS at 6 cpd and ganglion cell/inner plexiform layer thickness at inferotemporal and inferonasal macular sectors (ρ =0.222, p=0.023 and ρ =0.209, p=0.032, respectively). CS at 6 cpd demonstrated higher correlations with full macular thickness measurements, the strongest of which was with the central macular thickness in the superior 6×3 degree region (ρ =0.311, p=0.001). Contrast sensitivity at 6 cpd also had the strongest correlation with mean deviation of the 4 central VF points (ρ=−0.420; p<0.001). There was a significant correlation between logMAR visual acuity and contrast sensitivity at 6, 12, and 18 cpd (ρ =−0.306, −0.348 and −0.241, p<0.013, respectively). CONCLUSIONS Structural and functional measures showed a fair relationship with contrast sensitivity. This association was most prominent between full thickness macular measures or central VF parameters and CS at 6 cpd. Contrast sensitivity was not a reliable surrogate for glaucoma severity in this cross-sectional study.

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“…Third, topical anti-hypertensive medication was being administered to all eyes in the present study, which could have affected CS results. Partial reversibility of CS has been observed in glaucoma patients after IOP lowering treatment 20,21 . Moreover, topical medications may have altered the corneal surface, thereby affecting CS results.…”

Section: Resultsmentioning

confidence: 98%

Contrast sensitivity in glaucoma patients with visual field defects at different locations

Jang

Lee

2023

Sci Rep

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Contrast sensitivity (CS) is closely associated with vision-related quality of life in glaucoma patients. This cross-sectional study was performed to determine the relationship between CS and visual field (VF) sensitivity (VFS) according to the hemifield location of VF defects in 238 patients with primary open-angle glaucoma (POAG) who underwent 24-2 standard automated perimetry and CS measurement on the same day. Of the 238 eyes, 83, 58, and 47 eyes had VF defects in the superior, inferior and both hemifields, respectively, and 50 had no VF defects in either hemifield. Significant correlations between CS and VFS in all sectors were observed in the entire cohort (R2 = 0.103–0.315, all P < 0.001). However, CS poorly represented VF defects in eyes with single superior (R2 = 0.037–0.086) or inferior (R2 = 0.107–0.222) hemifield defects. Eyes with bi-hemifield VF defects showed significant correlations between VFS and CS at 0.3 m in all sectors (R2 = 0.200–0.406), but the correlation between VFS and CS at 5 m was significant only in the inferior sector (R2 = 0.224–0.348 vs. 0.081–0.126 in the inferior and superior sectors, respectively). Correlations between CS and VFS were dependent on CS distances and the presence of bi-hemifield VF defects. Although CS may not correlate with VFS in eyes with single-hemifield VF defects, it may reflect visual disability in eyes with bi-hemifield defects.

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Latanoprost-Induced Stabilization of Central Visual Function in Patients with Primary Open-Angle Glaucoma

Abstract: Compared with timolol maleate in Gelrite, latanoprost appears to significantly improve, or at least maintain, central visual function, as measured by CS, at different spatial frequencies in patients with POAG.

Cited by 5 publications

References 13 publications

Analysing the change in contrast sensitivity post-travoprost treatment in primary open-angle glaucoma patients using Spaeth Richman contrast sensitivity test

Analysing the change in contrast sensitivity post-travoprost treatment in primary open-angle glaucoma patients using Spaeth Richman contrast sensitivity test

Association of Structural and Functional Measures With Contrast Sensitivity in Glaucoma

Contrast sensitivity in glaucoma patients with visual field defects at different locations

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