P resentation with type A acute aortic dissection (TAAAD) is associated with high mortality and a 5-year survival of 32%, with operative therapy indicated to improve survival. 1,2 Prior cardiac surgery (PCS) may impact the presentation and outcomes of patients with TAAAD, and the ideal management of these patients is not clear. The reported operative mortality for repair of TAAAD occurring in patients with PCS varies from 5% to 54%.3,4 Some have argued a history of PCS should favor a nonoperative approach. [5][6][7] Several justifications are offered for this, including protection from aortic rupture and aortic insufficiency conferred by adhesions from previous surgery and previous aortic valve replacement, respectively.
8This study from the International Registry of Acute Aortic Dissection (IRAD) aims to determine the impact of PCS on the presentation and outcomes of patients with TAAAD. We hypothesize that PCS increases the risk of morbidity and mortality in patients who develop type A dissection, and that operative therapy should remain the preferred treatment modality in appropriately selected patients.
Methods
Registry DesignThe IRAD registry is composed of 31 centers in 11 countries. Participating centers report consecutive cases of acute dissection to the IRAD Coordinating Center at the University of Michigan, which performs internal checks for validity. The institutional review board at each center approved data collection. Further details of the registry have been published previously. Dissection had cardiac surgery before dissection, including coronary artery bypass grafting (34%), aortic or mitral valve surgery (36%), aortic surgery (42%), and other cardiac surgery (16%). Those with PCS were older, had a higher frequency of diabetes mellitus, hypertension, and atherosclerosis, and presented later from symptom onset to hospital presentation and diagnosis (all P<0.05). In-hospital mortality was significantly higher for PCS patients (34% versus 23%; P<0.001).