2023
DOI: 10.1038/s41440-023-01237-7
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Late age at menopause positively associated with obesity-mediated hypertension

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Cited by 6 publications
(5 citation statements)
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“…42,43 Another potential mechanism through which early age at menarche might act is via longer duration of exposure to high levels of estrogen, which has been found to increase the risk of developing hypertension. 44,45 Weight concerns are a highly prevalent source of chronic stress for many individuals in the US, yet relatively few studies have examined the associations between weight concerns and the development of hypertension. [46][47][48][49] Most of the previous research has been among females or samples that were predominantly female.…”
Section: Discussionmentioning
confidence: 99%
“…42,43 Another potential mechanism through which early age at menarche might act is via longer duration of exposure to high levels of estrogen, which has been found to increase the risk of developing hypertension. 44,45 Weight concerns are a highly prevalent source of chronic stress for many individuals in the US, yet relatively few studies have examined the associations between weight concerns and the development of hypertension. [46][47][48][49] Most of the previous research has been among females or samples that were predominantly female.…”
Section: Discussionmentioning
confidence: 99%
“…Consistent with previous studies, we also found that early menopause was associated with high odds of frailty. Studies have shown that there was a linear relationship between age at menopause and risk of CVD ( Zhu et al , 2019 ), and late age at menopause was positively associated with obesity-mediated hypertension ( Morimoto and Ichihara, 2023 ). These might explain the J-shape dose–response relationship of menopausal age with physical frailty in our study.…”
Section: Discussionmentioning
confidence: 99%
“…In the present study, older yet healthy males were recruited, as their blood pressure values are considered pre-hypertensive and without clinical cardiovascular diseases that would justify pharmacological prescription. Thus, the participants’ clinical condition in these studies [ 24 , 26 , 27 ] might have influenced the response to L-citrulline supplementation, as obesity and menopause are associated with hypertension progression and development [ 48 ]. Furthermore, except for one study that followed short-term supplementation [ 47 ], the rest followed a more prolonged supplementation, ranging from four to eight weeks, which could have influenced the effectiveness of the intervention.…”
Section: Discussionmentioning
confidence: 99%