Late calcification of the mitral–aortic junction causing transient complete atrio-ventricular block after mediastinal radiation of Hodgkin lymphoma: Multimodal visualization

Santoro, Francesco; Ieva, Riccardo; Lupo, Pierluigi; Pellegrino, Pier Luigi; Correale, Michele

doi:10.1016/j.ijcard.2011.07.070

Cited by 13 publications

(8 citation statements)

References 5 publications

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“…2,57 Calcification of the aortomitral ridge is a characteristic clue for those at risk of heart block. 120 Treatment of these ultimate complications should be in keeping with current guidelines.…”

Section: Introductionmentioning

confidence: 98%

Evaluation and Management of Patients With Heart Disease and Cancer: Cardio-Oncology

Herrmann

Lerman

Sandhu

et al. 2014

Mayo Clinic Proceedings

354

289

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The care for patients with cancer has advanced greatly over the past decades. A combination of earlier cancer diagnosis and greater use of traditional and novel systemic treatments has decreased cancer-related mortality. Effective cancer therapies, however, can result in short- and long-term co-morbidities that can decrease the net clinical gain by impacting quality of life and survival. In particular, cardiovascular complications of cancer treatments can have a profound impact on the health of cancer patients and are more common among those with recognized or unrecognized underlying cardiovascular diseases. A new discipline termed “cardio-oncology” has thus evolved to address the cardiovascular needs of cancer patients and optimize their care in a multidisciplinary approach. This review provides a brief introduction and background on this emerging field and then focuses on its practical aspects including: cardiovascular risk assessment and prevention before cancer treatment, cardiovascular surveillance and therapy during cancer treatment, and cardiovascular monitoring and management after cancer therapy. The content of this review is based on a literature search of PubMed between January 1, 1960, and February 1, 2014 using the search terms cancer, cardiomyopathy, cardiotoxicity, cardio-oncology, chemotherapy, heart failure, and radiation.

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Section: Introductionmentioning

confidence: 98%

Evaluation and Management of Patients With Heart Disease and Cancer: Cardio-Oncology

Herrmann

Lerman

Sandhu

et al. 2014

Mayo Clinic Proceedings

354

289

View full text Add to dashboard Cite

show abstract

“…Conduction disorders after radiotherapy have been described for the last 30 years, and atrioventricular block is associated with a dose around 52 Gy [26]. However, Santoro et al described one case of atrioventricular block after 6 years of mediastinal radiation [27]. All evidence suggests higher doses of radiation induce conduction disturbances than other cardiac disorders [23].…”

Section: Discussionmentioning

confidence: 99%

Long-Term Radiotherapy-Induced Cardiac Complications: A Case Report

et al. 2019

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Patient: Male, 48Final Diagnosis: Late cardiac complications postradiotherapySymptoms: Chest pain • dyspnea • syncopeMedication: —Clinical Procedure: Diagnostic and therapeutic techniques in cardiologySpecialty: CardiologyObjective:Unusual or unexpected effect of treatmentBackground:Tumor disease has improved survival due to therapeutic advances and early diagnosis. However, anti-neoplastic treatment involves generating harmful side effects in the body, both in the short-term and in the long-term. One of the most important side effects is cardiovascular disease after radiotherapy, which in addition to being influenced by classic cardiovascular risk factors, can be also be influenced by anti-neoplastic therapy, and represents the main cause of death after a second cancer. We present a case that synthesizes the most relevant and determining aspects of radiotherapy-induced heart disease.Case Report:We present the case of a 48-year-old male with a personal history of mediastinal Hodgkin lymphoma who was treated with local radiotherapy 20 years ago, and who was admitted to hospital due to dyspnea and oppressive chest pain with efforts. He was diagnosed with severe aortic stenosis, and a coronary angiography confirmed the existence of coronary disease. Two years before, he had been admitted to hospital due to syncope and a pacemaker had been implanted. This patient experienced several cardiovascular complications that could be attributed to the radiotherapy treatment received in his past.Conclusions:Radiotherapy shows multiple cardiological complications, especially when applied at the thoracic level. This fact is very relevant, and this report can help determine the aspects of radiotherapy-induced heart disease affecting the mortality and morbidity of these patients.

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“…The first one was treated in his youth with chemotherapy and radiotherapy to the mediastinum, for Hodgkin's Lymphoma, and treated again, a generation later, by a coronary artery bypass graft (GABG) operation and by permanent pacemaker therapy. Santoro et al described in 2012 a case of a 44-year-old man with history of Hodgkin lymphoma, treated with chemo-and radio-therapy 6 years earlier, who presented with episodes of syncope and complete AV block and needed pacemaker therapy implantation [29]. Two years later, Trapani et al described a 47-year-old female patient with no history of cardiac disease, who presented with recurrent syncope, high degree AV Block, treated with temporary and permanent pacemaker implantation.…”

Section: Discussionmentioning

confidence: 99%

Chest Irradiation Associated Cardio-Vascular Disease

Yahalom¹,

Rozner²,

Nahir³

et al. 2016

WJCD

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Background: The heart and great vessels were once thought to be relatively resistant to the damaging effect of radiation therapy. There is now clear evidence that thoracic irradiation may cause acute inflammation and progressive fibrosis of different structures, including the heart valves, the myocardium and the pericardium, the coronary arteries and the conduction system. As new therapies have improved survival, many patients with cancer (mostly Hodgkin's disease and breast cancer) are now at risk of cardiovascular (CV) complications following radiation therapy. Objectives: To raise awareness of CV complications following chest irradiation. Method: We present 5 patients that we treated during a short period of time (between June 2013 (6/2013) and February 2015 (2/2016)), who suffered CV involvement that needed therapy, following chest irradiation. Conclusions: Patients after chest irradiation should be followed periodically, in order to diagnose and treat CV complications, in time.

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Late calcification of the mitral–aortic junction causing transient complete atrio-ventricular block after mediastinal radiation of Hodgkin lymphoma: Multimodal visualization

Cited by 13 publications

References 5 publications

Evaluation and Management of Patients With Heart Disease and Cancer: Cardio-Oncology

Evaluation and Management of Patients With Heart Disease and Cancer: Cardio-Oncology

Long-Term Radiotherapy-Induced Cardiac Complications: A Case Report

Chest Irradiation Associated Cardio-Vascular Disease

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