2015
DOI: 10.3324/haematol.2014.116574
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Late cardiomyopathy in childhood acute myeloid leukemia survivors: a study from the L.E.A. program

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Cited by 25 publications
(31 citation statements)
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“…As well, we observed only a single episode of heart failure in the dexrazoxane group which was temporally associated with a sepsis event. In addition, comparing the incidence of clinically significant cardiac events or heart failure secondary to anthracycline exposure would require a significantly longer follow-up and was not the primary aim of this analysis 25, 36 .…”
Section: Discussionmentioning
confidence: 99%
“…As well, we observed only a single episode of heart failure in the dexrazoxane group which was temporally associated with a sepsis event. In addition, comparing the incidence of clinically significant cardiac events or heart failure secondary to anthracycline exposure would require a significantly longer follow-up and was not the primary aim of this analysis 25, 36 .…”
Section: Discussionmentioning
confidence: 99%
“…This assumption is supported in some of the above-mentioned studies (Creutzig et al, 2007;Temming et al, 2011). Conversely, spontaneous improvement of cardiac function in several patients has also been reported (Barlogis et al, 2015). Conversely, spontaneous improvement of cardiac function in several patients has also been reported (Barlogis et al, 2015).…”
Section: Studies Of the Cardiotoxicity Of Aml Treatmentmentioning
confidence: 62%
“…Total body irradiation (TBI) and graft-versus host disease (GvHD) are major risk factors. This will probably reduce the risk of late cardiotoxicity due to HCST, which is indicated in the French study where relapse of AML but not HSCT was reported to be a risk factor for cardiotoxicity (Barlogis et al, 2015). This will probably reduce the risk of late cardiotoxicity due to HCST, which is indicated in the French study where relapse of AML but not HSCT was reported to be a risk factor for cardiotoxicity (Barlogis et al, 2015).…”
Section: Haematopoietic Stem Cell Transplantationmentioning
confidence: 99%
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“…Higher doses of anthracyclines (>250 mg/m 2 ) are directly associated with an exponentially higher risk of developing cardiac pathogenesis [2,3]. Moreover, anthracycline leads to cardiac complications like cardiomyopathy, reduced left ventricular ejection fraction (<55 %) and higher arterial stiffness in 16 % of all AML-long-term-survivors [1,4,5]. Since children and young adults tend to suffer from this disease a closer look towards long-term functional outcome of every single survivor has to be taken into account.…”
Section: Introductionmentioning
confidence: 99%