Originally described by Jean-Martin Charcot in patients with tertiary syphilis and associated peripheral neuropathy, Charcot osteoarthropathy is an uncommon, yet debilitating, condition that has been shown to negatively affect health-related quality of life in today's diabetic population. 11 Long-standing diabetes mellitus has been identified as the currently most common predisposing medical condition to the development of Charcot osteoarthropathy. 4 Proposed theories of pathogenesis include both the neurovascular and neurotraumatic theories. 15 There is a growing body of evidence that dysregulation of inflammatory and bone metabolism pathways, with upregulation of receptor activator of nuclear factor κ-β ligand (RANK-L), leads to osteoclast overactivation and bone resorption. 6,14,15 Clinically, midfoot osteoarthropathy manifests as a noninfectious, osteolytic process that may ultimately result in profound deformity and instability from bone and joint collapse. 11 In patients with associated peripheral neuropathy and diabetes mellitus, ulceration often results from deformity, potentially leading to limb-threatening deep infection. Initial management consists of nonoperative measures, but if these interventions fail to prevent progressive collapse or ulceration, operative intervention may be indicated to 799966F AIXXX10.