Late Cutaneous Syphilis and Neurosyphilis

Schoutens, C.; Boute, V.; Govaerts, D.; Dobbeleer, Gilbert De

doi:10.1159/000246432

Cited by 7 publications

(3 citation statements)

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“…In the pre-antibiotic era, general paresis and tabes dorsalis were the most commonly recognized forms of NS [7]. During recent decades, some authors have reported changes in the clinical patterns of this disease [8,9,10,11], and these changes have generally been attributed to the expanded use of antibiotics and the growing number of patients who are coinfected with HIV. In recent years, there has been a remarkable increase in the incidence of NS in China [4].…”

Section: Introductionmentioning

confidence: 99%

Clinical Spectrum of Neurosyphilis among HIV-Negative Patients in the Modern Era

et al. 2013

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Background: The clinical spectrum of neurosyphilis (NS) has changed over time. Objective: To describe the clinical spectrum and characteristics of NS in HIV-negative patients. Methods: A retrospective chart review was performed for 149 in patients with NS. Result: All patients were >25 years old, including 16.8% asymptomatic for NS, 15.4% with syphilitic meningitis, 24.2% with meningovascular NS, 38.9% with general paresis, 4.0% with tabes dorsalis and 0.7% with gummatous NS. The original misdiagnosis rate was 84.6%. All 149 patients had positive serum Treponema pallidum particle agglutination (TPPA) and rapid plasma reagin (RPR). The overall positive rates of cerebrospinal fluid RPR (CSF-RPR) and CSF-TPPA were 57.0 and 89.9%, respectively. CSF pleocytosis and elevated CSF protein were found in 40.3% of patients. Nonspecific abnormal brain magnetic resonance imaging and electroencephalography findings were present in 60.4 and 54.8% of NS patients, respectively. Conclusions: NS has various clinical manifestations, laboratory findings and magnetic resonance imaging and electroencephalography findings, but all studies lack specificity. Every patient with neurological or psychiatric symptoms that are without unambiguous causes should have blood tests for syphilis. When serology proves positive, patients should undergo CSF examination.

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Section: Introductionmentioning

confidence: 99%

Clinical Spectrum of Neurosyphilis among HIV-Negative Patients in the Modern Era

et al. 2013

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“…Tertiary syphilis can present as gummatous skin and mucosal lesions, as well as involves cardiovascular and neurologic systems (Schoutens et al 1996 ;Chudomirova et al 2009 ). Skin lesions are solitary or multiple and consist of superfi cial nodular and deep gummatous subtypes.…”

Section: Clinical Featuresmentioning

confidence: 99%

“…Benign gummatous syphilis shows granulomatous infl ammation with central zones of acellular necrosis in involved organs. In cutaneous lesions, blood vessels throughout the dermis and subcutaneous fat exhibit endarteritis obliterans, with variable angiocentric plasma cell infi ltrates (Schoutens et al 1996 ;Wu et al 2000 ;Rocha et al 2004 ;Chudomirova et al 2009 ).…”

Section: Tertiary Syphilismentioning

confidence: 99%