Late distant metastases of malignant thymoma associated with peripheral <scp>T</scp>‐cell lymphocytosis

Puljiz, Željko; Karin, Željka; Bratanić, Andre; Kresak, Velka Gveric; Puljiz, Mario; Forempoher, Gea; Durdov, Merica Glavina; Bago, Josip; Pevec, Mira Radulović; Pevec, Branko

doi:10.1111/pin.12101

Cited by 5 publications

(5 citation statements)

References 8 publications

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“…Malignant thymomas are usually determined by the invasiveness into nearby tissues or distant metastasis. The recurrence of thymomas is rare, and distant metastasis is reported by only a few cases [1]. In the present study, the patient was diagnosed with malignant thymoma with diaphragm and pleural infiltration at the onset.…”

Section: Discussionmentioning

confidence: 62%

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Bone metastasis of malignant thymomas associated with peripheral T-cell lymphocytosis

Zhao

Zhou

et al. 2016

BMC Surg

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BackgroundMalignant thymomas are rarely associated with bone metastasis and T-cell lymphocytosis.Case presentationA 47–year-old female patient was admitted to our hospital for ptosis. A diagnosis of malignant thymoma was made based on the thymectomy and pathological result. Peripheral T-cell lymphocytosis and bone metastasis were found later. T-cell lymphocytosis was relived after surgical and radiation therapy to the metastasis.ConclusionPeripheral T-cell lymphocytosis is a rare paraneoplastic phenomenon associated with thymomas. This report is the first to describe an invasive thymoma with late bone metastasis accompanied with T-cell lymphocytosis. We should be aware of peripheral T-cell lymphocytosis in thymomas and it may contribute to a better understanding of the complex physiology and pathogenesis of thymoma.

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Section: Discussionmentioning

confidence: 62%

“…Thymomas are usually slow growing with more local recurrence rather than metastasis. Sporadic cases with late distant metastasis, including lungs, pleura, liver, thyroid and bones, have been reported [1]. …”

Section: Introductionmentioning

confidence: 99%

Bone metastasis of malignant thymomas associated with peripheral T-cell lymphocytosis

Zhao

Zhou

et al. 2016

BMC Surg

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“…Most of these T lymphocytes experience apoptosis before relapse in the systemic blood flow, thus patients with thymoma usually show normal peripheral lymphocyte count compared to healthy controls 22 . However, there have been some studies reporting that sporadic patients affected by aggressive TETs show absolute peripheral polyclonal lymphocytosis 23–25 . In the patients with autoimmune diseases, autoimmunity might affect the results.…”

Section: Discussionmentioning

confidence: 99%

“…22 However, there have been some studies reporting that sporadic patients affected by aggressive TETs show absolute peripheral polyclonal lymphocytosis. [23][24][25] In the patients with autoimmune diseases, autoimmunity might affect the results.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of systemic inflammatory markers and the nutrition status in thymic epithelial tumors with complete resection

et al. 2022

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BackgroundRecent studies have shown that several systemic in ammatory markers and the nutrition status, including the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-tolymphocyte ratio (PLR), and prognostic nutritional index (PNI), are useful prognostic factors in several malignant tumors. The present study explored the prognostic value of the NLR, MLR, PLR, and PNI in thymic epithelial tumor (TET) patients who underwent complete resection. MethodsA total of 158 TET patients who underwent complete resection were involved in the analysis. Their NLR, MLR, PLR, and PNI values were obtained from a blood examination within one month before the initiation of treatment. A receiver operating characteristic curve analysis was conducted to determine the optimal cut-off values. ResultsThe enrolled patients were strati ed by cut-offs of 4.35 for the NLR, 0.22 for the MLR, 130.18 for the PLR, and 44.02 for the PNI. A univariate analysis revealed that high-grade malignant TET, including type B2 and B3 thymoma, thymic carcinoma, and thymic neuroendocrine tumor; an advanced Masaoka stage; a high NLR; a high MLR; and a low PNI were signi cant predictors of a poor disease-free survival (DFS). A multivariate analysis con rmed that an advanced Masaoka stage (HR = 5.5557, P = 0.0007) and a high MLR (HR = 3.3371, P = 0.0264) were independent predictors of a poor DFS. ConclusionsOur study demonstrated that the pretreatment MLR was an independent predictor of the DFS in patients with TETs who underwent complete resection.

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“…To the best of our knowledge, this is the first case report of PB and BM CD8+ T-cell lymphocytosis occurring concurrently with invasive thymoma. In most reported cases of T-cell lymphocytosis associated with thymoma, lymphocytes consist of a mixed mature population of T cells with a normal or slightly abnormal CD4:CD8 ratio [ 2 4 5 6 ]. In the present case, besides peripheral T-cell lymphocytosis, a predominance of mature lymphocytes was found in the BM, which primarily raised the suspicion of T-cell leukemia/lymphoma.…”

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confidence: 99%

Unusual association of CD8+ T-cell lymphocytosis with invasive thymoma

et al. 2015

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Late distant metastases of malignant thymoma associated with peripheral T‐cell lymphocytosis

Cited by 5 publications

References 8 publications

Bone metastasis of malignant thymomas associated with peripheral T-cell lymphocytosis

Bone metastasis of malignant thymomas associated with peripheral T-cell lymphocytosis

Prognostic value of systemic inflammatory markers and the nutrition status in thymic epithelial tumors with complete resection

Unusual association of CD8+ T-cell lymphocytosis with invasive thymoma

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