Late effects after childhood brain tumor treatment: it’s not just about the radiation

Tsang, Derek S.; Edelstein, Kim

doi:10.1093/neuonc/noz054

Cited by 3 publications

(2 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…all likely contribute to neuropsychological change at baseline and over time. 46 We found strong co-linearity between different supratentorial brain structures. There are several reasons for this.…”

Section: Neuro-oncologymentioning

confidence: 62%

Intellectual changes after radiation for children with brain tumors: which brain structures are most important?

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background The objective of this study was to evaluate the contribution of radiation dose to different intracranial structures on changes in intellectual function for children with brain tumors. Methods We evaluated children with brain tumors treated from 2005-2017 who had longitudinal neuropsychological assessments and available photon dosimetric data (if RT given). Full scale intelligence quotient (FSIQ) and index scores were evaluated (perceptual reasoning [PRI], processing speed [PSI], verbal comprehension [VCI] and working memory [WMI]). Multivariable linear mixed effects models were used to model endpoints, with age at RT and dose to different brain regions as fixed effects and patient-specific random intercepts. P-values (p*) were adjusted for multiple comparisons. Results Sixty-nine patients were included, 56 of whom received RT. Median neuropsychological follow-up was 3.2 years. Right temporal lobe mean dose was strongly associated with decline in FSIQ (p* = 0.005); with each gray increase in mean dose, there was a decrease of 0.052 FSIQ points per year. Dose to 50% (D50) of the supratentorial brain was associated with decline in PSI (p* = 0.006) and WMI (p* = 0.001). Right and left hippocampus D50 were individually strongly associated with declines in VCI (p* = 0.009 for each). Presence of ventriculoperitoneal shunt decreased FSIQ by 10 points. Conclusions We reported associations between dosimetry to specific brain regions and intellectual outcomes, with suggested avoidance structures during RT planning. These models can help clinicians anticipate changes in neurocognition post-RT and guide selection of an optimal RT plan.

show abstract

Section: Neuro-oncologymentioning

confidence: 62%

Intellectual changes after radiation for children with brain tumors: which brain structures are most important?

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…In addition to age at RT and years of education, other non-RT treatment factors may influence cognitive outcomes, including surgery, 16 , 32 surgical approach, 33 direct tumor effects and tumor type, 34 and systemic therapy. 17 , 35 Unfortunately, our data were not able to evaluate all of these factors together due to a limited sample size. Some patients had their baseline assessment a few weeks after RT, though this was accounted for in the GEE model.…”

Section: Discussionmentioning

confidence: 93%

Neurocognitive Performance in Adults Treated With Radiation for a Primary Brain Tumor

Tsang

Khandwala²,

Liu³

et al. 2022

Advances in Radiation Oncology

Self Cite

View full text Add to dashboard Cite

Effects of Yoga-Based Interventions on Cancer-Associated Cognitive Decline: a Systematic Review

et al. 2020

View full text Add to dashboard Cite

Late effects after childhood brain tumor treatment: it’s not just about the radiation

Cited by 3 publications

References 11 publications

Intellectual changes after radiation for children with brain tumors: which brain structures are most important?

Intellectual changes after radiation for children with brain tumors: which brain structures are most important?

Neurocognitive Performance in Adults Treated With Radiation for a Primary Brain Tumor

Effects of Yoga-Based Interventions on Cancer-Associated Cognitive Decline: a Systematic Review

Contact Info

Product

Resources

About