Late Effects of Roentgen Irradiation

Bennett, Leslie R.; Chastain, Sarah M.; Flint, Jerry S.; Hansen, Robert A.; Lewis, Alvin E.

doi:10.1148/61.3.411

Cited by 25 publications

(3 citation statements)

References 16 publications

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“…An increased incidence of non-neoplastic diseases, particularly at high doses 5 has been observed by several workers (Bennett, Chastain, Flint, Hansen & Lewis 1953;Nowell & Cole 1959) but no correlation with decreased incidence of neo plasms was attempted.…”

Section: (B) Dose-resjponse Relationship For Causes Of Deathmentioning

confidence: 98%

Long-term effects of a single whole-body exposure of mice to ionizing radiations - II. Causes of death

Lindop

Rotblat

1961

Proc. R. Soc. Lond. B.

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The causes of death in mice exposed at the age of 30 days to a single whole-body dose of 15 MeV X-rays have been analyzed from the point of view of both percentage incidence and distribution in time. Ten groups of death causes were used, based on post-mortem findings. In the lower dose groups (50 to 457 r), the percentage incidence was found, in most cases, to vary very little with dose, but some diseases, e. g. leukaemia, did show a definite increase, and others, e. g. pulmonary tumours, a definite decrease with increasing dose. The changes in incidence were linearly related to the dose. The analysis of survival curves for each cause of death separately has revealed that while all causes were advanced by radiation, some were advanced more than others. A definite correlation was found between the acceleration of a given cause of death and the rate of change of the percentage incidence with dose. This suggests that the change of incidence is merely the result of the changed times of onset of disease; an actuarial correction has confirmed this suggestion. It is concluded that the probability of any one disease occurring remains the same in irradiated as in the control animals, the main effect of the radiation being an advancement, at different rates, of all causes of death. The age of the animal at irradiation may be an important factor in determining the relative acceleration of the different diseases. In the high dose groups (549 to 780 r) a definite decrease in incidence of neoplastic diseases has been established. This may be due to a 4 'radiotherapeutic’ effect in cells which later in life might have become manifest as neoplasms.

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Section: (B) Dose-resjponse Relationship For Causes Of Deathmentioning

confidence: 98%

Long-term effects of a single whole-body exposure of mice to ionizing radiations - II. Causes of death

Lindop

Rotblat

1961

Proc. R. Soc. Lond. B.

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“…There are a number of reports, both from radiotherapists and animal experimenters, of changes in the kidneys (12,13,14) and the central nervous system (15,16,17) following a long time after irradiation, which seem to have special importance in relation to ageing since there are indications that (12,16) the pathological conditions observed are secondary to sclerotic changes in the blood vessels.…”

Section: Is the Radiation Effect Similar To Spontaneous Ageing?mentioning

confidence: 99%

Accelerated Ageing – a Long Term Effect of Exposure to Ionizing Radiations

Alexander¹

1957

Gerontology

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“…Bennett et al (197) have presented data on the long-term survival of rats protected from acute lethality by anoxia; they recorded a marked decrease in life expectancy, with an increase in frequency of deaths due to pneumonia.…”

Section: Radiation Toxicitymentioning

confidence: 99%

Vertebrate Radiobiology (Lethal Actions and Associated Effects)

Thomson¹

1954

Annu. Rev. Nucl. Sci.

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Late Effects of Roentgen Irradiation

Cited by 25 publications

References 16 publications

Long-term effects of a single whole-body exposure of mice to ionizing radiations - II. Causes of death

Long-term effects of a single whole-body exposure of mice to ionizing radiations - II. Causes of death

Accelerated Ageing – a Long Term Effect of Exposure to Ionizing Radiations

Vertebrate Radiobiology (Lethal Actions and Associated Effects)

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