Late Endocrine Effects of L-Dopa, 5-HTP, and 6-OH-Dopa Administered to Neonatal Rats

Bakke, John L.; Lawrence, Nancy; Robinson, Susan; Bennett, Jane; Bowers, Cyril

doi:10.1159/000122749

Cited by 9 publications

(4 citation statements)

References 13 publications

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“…The efficacy of ovarian sympathectomy was demonstrated with fluorescence microscopy. Intrabursal 6-OliDA injection minimized systemic effects and permitted a more specific ovarian sympathectomy than previous studies which administered 6-OliDA intraperitoneally and sympathectomized the abdominal viscera in addition to the ovaries (MacDonald and Airaksinen, 1974;Johns et al, 1975;Bakke et al, 1978;Lawrence et al, 1982). The intrabursal technique did not affect ovulation since all the solvent injected control animals had normal 4 day estrous cycles.…”

Section: Discussionmentioning

confidence: 94%

Ovarian Sympathectomy in the Golden Hamster: Effects on Estrous Cyclicity and Follicular Development

Te¹,

Ie²,

Hw³

2009

Exp Clin Endocrinol Diabetes

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The role of adrenergic nerves in estrous cyclicity and follicular growth was studied in sympathectomized hamster ovaries. Specific ovarian sympathectomy was accomplished by injection of 6-hydroxydopamine (6-OHDA) into the ovarian bursal sac. Ovarian sympathectomy abolished all fluorescent adrenergic nerves 4, 8 or 12 days after treatment. Bilateral ovarian sympathectomy on metestrus altered the first estrous cycle in 53% of the animals and 20% had an altered second cycle. All sham injected animals had normal cycles. Four days after sympathectomy, there was a decrease in healthy follicles 80-240 microns and 250-340 microns in diameter and increased atresia of follicles 80-240 microns and 350-440 microns in diameter compared to solvent treated ovaries. Bilateral 6-OHDA treatment did not affect ovarian weight, number of corpora lutea or the total number of follicles per ovary. These observations suggest that ovarian adrenergic nerves modulate healthy follicular development in the golden hamster.

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Section: Discussionmentioning

confidence: 94%

Ovarian Sympathectomy in the Golden Hamster: Effects on Estrous Cyclicity and Follicular Development

Te¹,

Ie²,

Hw³

2009

Exp Clin Endocrinol Diabetes

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“…Eye opening, a developmental landmark, was delayed by two days in four out of five female rats and all male rats treated with BMAA on PND 5 and in all the male and female rats treated with BMAA on PND 3 or 4. Eye opening is related to the serotoninergic and dopaminergic system, and its delay is considered a significant indicator of reduced dopamine and/or serotonin in the brain [ 62 , 63 ]. It is interesting to note that the other gross clinical deficits observed in BMAA-exposed rats in this study are also, for the most part, comparable to those observed in rats that have been exposed to agents that interfere with dopaminergic and/or serotonergic transmission.…”

Section: Resultsmentioning

confidence: 99%

β-N-Methylamino-L-alanine (BMAA) Toxicity Is Gender and Exposure-Age Dependent in Rats

Scott

Downing

2017

Toxins

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Cyanobacterial β-N-methylamino-l-alanine (BMAA) has been suggested as a causative or contributory factor in the development of several neurodegenerative diseases. However, no BMAA animal model has adequately shown clinical or behavioral symptoms that correspond to those seen in either Alzheimer’s Disease (AD), Amyotrophic Lateral Sclerosis (ALS) or Parkinson’s Disease (PD). We present here the first data that show that when neonatal rats were exposed to BMAA on postnatal days 3, 4 and 5, but not on gestational day 14 or postnatally on days 7 or 10, several AD and/or PD-related behavioral, locomotor and cognitive deficits developed. Male rats exhibited severe unilateral hindlimb splay while whole body tremors could be observed in exposed female rats. BMAA-exposed rats failed to identify and discriminate a learned odor, an early non-motor symptom of PD, and exhibited decreased locomotor activity, decreased exploration and increased anxiety in the open field test. Alterations were also observed in the rats’ natural passive defense mechanism, and potential memory deficits and changes to the rat’s natural height avoidance behavior could be observed as early as PND 30. Spatial learning, short-term working, reference and long-term memory were also impaired in 90-day-old rats that had been exposed to a single dose of BMAA on PND 3–7. These data suggest that BMAA is a developmental neurotoxin, with specific target areas in the brain and spinal cord.

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“…During the prenatal and early postnatal periods, serotonin serves as a signal factor in cell proliferation and differentiation in the nervous tissue; it also influences the development of the epithelial tissue [ 15 , 24 ]. It was shown that neonatal administration of the serotonin precursor 5-hydroxytryptophan leads to earlier eye opening [ 25 ]. It can be assumed that the increase in the activity of the serotoninergic system during this period accelerates the development of the visual analyzer.…”

Section: Discussionmentioning

confidence: 99%

Effects of Neonatal Fluvoxamine Administration on the Physical Development and Activity of the Serotoninergic System in White Rats

Glazova¹,

Merchieva²,

Володина³

et al. 2014

Acta Naturae

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Selective serotonin reuptake inhibitors (SSRIs), including fluvoxamine, are widely used to treat depressive disorders in pregnant women. These antidepressants effectively penetrate through the placental barrier, affecting the fetus during the critical phase of neurodevelopment. Some clinical studies have linked prenatal exposure to SSRIs with increased neonatal mortality, premature birth, decreased fetal growth and delay in psychomotor development. However, the effects of prenatal exposure to SSRIs remain unknown. The administration of SSRIs in rodents during the first postnatal weeks is considered as an model for studying the effects of prenatal SSRIs exposure in human. The aim of this work was to study the acute effects of chronic fluvoxamine (FA) administration in white rat pups. The study was carried out in male and female rat pups treated with FA (10 mg/kg/day, intraperitoneally) from postnatal days 1 to 14. The lethality level, body weight, age of eye opening, and motor reflex maturation were recorded. The contents of biogenic amines and their metabolites in different brain structures were also determined. It was shown that neonatal FA administration led to increased lethality level, reduced body weight, and delayed maturation of motor reflexes. Furthermore, increased noradrenalin level in hypothalamus, serotonin level in hippocampus and serotonin metabolite 5-HIAA level in frontal cortex, hypothalamus, hippocampus, and striatum were observed in drug-treated animals compared to the control group. We can conclude that the altered activity of the serotoninergic system induced by fluvoxamine administration at early developmental stages leads to a delay in physical and motor development.

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Late Endocrine Effects of L-Dopa, 5-HTP, and 6-OH-Dopa Administered to Neonatal Rats

Cited by 9 publications

References 13 publications

Ovarian Sympathectomy in the Golden Hamster: Effects on Estrous Cyclicity and Follicular Development

Ovarian Sympathectomy in the Golden Hamster: Effects on Estrous Cyclicity and Follicular Development

β-N-Methylamino-L-alanine (BMAA) Toxicity Is Gender and Exposure-Age Dependent in Rats

Effects of Neonatal Fluvoxamine Administration on the Physical Development and Activity of the Serotoninergic System in White Rats

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