Late Functional Loss in Nonparalytic Polio

Falconer, M; Bollenbach, Edward

doi:10.1097/00002060-200001000-00006

Cited by 12 publications

(10 citation statements)

References 16 publications

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“…Poliomyelitis is a devastating neurologic disease that has greatly impacted humanity for millennia (Falconer and Bollenbach, 2000; Paul, 1971). It is propagated by the human poliovirus, a positive sense single stranded RNA virus (Ryan and Ray, 2014).…”

Section: Introductionmentioning

confidence: 99%

Poliovirus Receptor: More than a simple viral receptor

et al. 2017

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The human poliovirus receptor (PVR) is a cell surface protein with a multitude of functions in human biology. PVR was initially identified as the receptor for the human poliovirus and recent discoveries have given a greater insight into both its morphology and its function. Alternative splicing of the PVR gene results in a total of 4 alternatively spliced isoforms. Two of these isoforms lack a complete transmembrane domain and are considered soluble and block viral infection; the remaining two transmembrane isoforms differ only at their extreme C-terminal domains resulting in differential localization in epithelia and polarity of viral infection. In addition to its role as a receptor for the human poliovirus, several native biological functions have also been uncovered. PVR is an important cell adhesion protein and is involved in the transendothelial migration of leukocytes. Through its interactions with CD226 and TIGIT, transmembrane proteins found on leukocytes, PVR is a key regulator of the cell-mediated immune response. As PVR is differentially regulated in a broad spectrum of cancers, it has a strong potential for clinical use as a biomarker. PVR is also a possible target for novel cancer therapies. Utilizing its natural tropism for PVR, a genetically modified form of the live attenuated poliovirus vaccine is currently being tested for its ability to locate and destroy certain tumors. These recent studies emphasize the importance of PVR in human biology and demonstrate its utility beyond being a viral receptor protein.

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Section: Introductionmentioning

confidence: 99%

Poliovirus Receptor: More than a simple viral receptor

et al. 2017

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“…Dans sa forme symptomatique, elle se manifeste par une atteinte neurologique (classiquement une paraplégie asymé-trique sans troubles des sensibilités) ou extra-neurologique (poliomyélite abortive) [1]. Il s'agit d'une affection redoutable, tant à cause de son caractère contagieux (épidémies fréquen-tes) que de la lourdeur du handicap qu'elle génère.…”

Section: Introductionunclassified

Paralysie flasque aiguë chez l’enfant au Bénin : aspects topographiques et étiologiques

Alagnidé

Kpadonou

Moevi

et al. 2015

Journal de Réadaptation Médicale : Pratique et Formation en Méd

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“…The incidence, symptoms and severity of PPS vary and some patients are known to develop weakness, atrophy, fatigue, muscle and joint pain and other complications; however, the absence of its incidence or severity has also been reported in some polio survivors1. There have been reports that even non-paralytic polio patients succumb to PPS2.…”

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confidence: 99%

The genetics of post-polio syndrome - much to be unravelled!

Saraswathy¹

2016

Indian Journal of Medical Research

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Late Functional Loss in Nonparalytic Polio

Cited by 12 publications

References 16 publications

Poliovirus Receptor: More than a simple viral receptor

Poliovirus Receptor: More than a simple viral receptor

Paralysie flasque aiguë chez l’enfant au Bénin : aspects topographiques et étiologiques

The genetics of post-polio syndrome - much to be unravelled!

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