Late Growth and Changes in Body Composition Influence Odds of Developing Retinopathy of Prematurity among Preterm Infants

Ingolfsland, Ellen C.; Haapala, Jacob; Buckley, Lauren A.; Demarath, Ellen W.; Guiang, Sixto F.; Ramel, Sara E.

doi:10.3390/nu12010078

Cited by 8 publications

(6 citation statements)

References 27 publications

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“…In recent years, more and more studies have found the importance of development and pathogenesis of ROP [ 28 ]. Vitreous injection of anti-VEGF is also used more and more to treat ROP [ 29 – 31 ].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Combuxil and Leizumab on Retinal Function and Serum Interleukin-17A in Premature Infants with Retinopathy

Ren

et al. 2022

Computational and Mathematical Methods in Medicine

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Objective. To investigate the effects of Compaximab and raizumab on retinal function and serum interleukin-17A level in retinopathy of prematurity. Methods. Sixty cases of retinopathy of prematurity treated in our hospital from February 2019 to April 2021 were selected. The patients were randomly divided into control group ( n = 30 ) and research group ( n = 30 ). The control group was treated with Compaq and the research group was treated with razumab. The curative effect, retinal function, incidence of complications, intraocular pressure at different time, and the level of serum interleukin-17A were compared. Results. Compared with the two groups, the curative effect of the research group 93.33% (28/30) was greater than that of the control group 66.67% (20/30), and the difference was statistically significant ( P < 0.05 ). Compared with the incidence of complications, the incidence of corneal opacity, lens opacity, preretinal and vitreous hemorrhage, endophthalmitis, and traction retinal detachment in the research group was greatly lower, and the difference was statistically significant ( P < 0.05 ). Following the therapy, the IOP of the two groups decreased at different times. The IOP of 1 min, 10 min, and 30 min in the research group was obviously lower, and the difference was statistically significant ( P < 0.05 ). Following treatments, the levels of serum IL-17A were decreased. Compared with the control group, the level of serum IL-17A in the research group was greatly downregulated, and the difference was statistically significant ( P < 0.05 ). Conclusion. Intravitreal injection of razumab is an effective treatment for retinopathy of prematurity, which can effectively improve the retinal function of infants. The level of serum interleukin-17A can be reduced and intraocular pressure can be regulated, which is safe and effective.

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Section: Discussionmentioning

confidence: 99%

The Effects of Combuxil and Leizumab on Retinal Function and Serum Interleukin-17A in Premature Infants with Retinopathy

Ren

et al. 2022

Computational and Mathematical Methods in Medicine

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“…Kim et al reported poor postnatal weight gain within the first two weeks of life as an independent risk factor for the development of severe ROP [ 143 ]. However, Ingolfsland et al reported that slow growth from 32 to 37 weeks post-conception is also associated with ROP ≥ stage 2, suggesting that growth during both the avascular and neovascular phases of ROP development impacts the severity of ROP [ 144 ].…”

Section: Perinatal and Neonatal Risk Factorsmentioning

confidence: 99%

Modifiable Risk Factors and Preventative Strategies for Severe Retinopathy of Prematurity

Prasad

Ingolfsland

Christiansen

2023

Life

Self Cite

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Severe ROP is characterized by the development of retinal fibrovascular proliferation that may progress to retinal detachment. The purpose of this report is to review five of the most common and well-studied perinatal and neonatal modifiable risk factors for the development of severe ROP. Hyperoxemia, hypoxia, and associated prolonged respiratory support are linked to the development of severe ROP. While there is a well-established association between clinical maternal chorioamnionitis and severe ROP, there is greater variability between histologic chorioamnionitis and severe ROP. Neonatal sepsis, including both bacterial and fungal subtypes, are independent predictors of severe ROP in preterm infants. Although there is limited evidence related to platelet transfusions, the risk of severe ROP increases with the number and volume of red blood cell transfusions. Poor postnatal weight gain within the first six weeks of life is also strongly tied to the development of severe ROP. We also discuss preventative strategies that may reduce the risk of severe ROP. Limited evidence-based studies exist regarding the protective effects of caffeine, human milk, and vitamins A and E.

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“…Ingolfsland and colleagues found that improved weight gains between 32 and 37 weeks postmenstrual age was associated with reduced risk of Stage ≥2 retinopathy of prematurity. 11 Retinopathy of prematurity is one example of pretermspecific critical illnesses that will prolong NICU admission.…”

Section: Prevalence Of Premature Births In the United Statesmentioning

confidence: 99%

“…The rate of growth velocity is an outcome measure frequently analyzed when looking at the prevalence of comorbidities in this population. Ingolfsland and colleagues found that improved weight gains between 32 and 37 weeks postmenstrual age was associated with reduced risk of Stage ≥2 retinopathy of prematurity 11 . Retinopathy of prematurity is one example of preterm‐specific critical illnesses that will prolong NICU admission.…”

Section: Introductionmentioning

confidence: 99%

Measuring growth in critically ill neonates and children

Bracken,

Pappas,

Wilkins

et al. 2023

Nut in Clin Prac

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Critical illness increases the risk of malnutrition in both infants and children. Malnutrition risk is multifactorial and includes premorbid factors as well as changes in nutrient metabolism and energy demands during critical illness. Inadequate nutrition has been linked to poor health outcomes and prolonged length of stay in the intensive care unit, demonstrating the importance of both recognizing and addressing malnutrition in this population. Assessing growth and identifying malnutrition requires methodical measurement of growth and a collaborative, multimodal approach to nutrition assessment. Among the nutrition assessment and growth evaluation tools, neonatal, preterm, pediatric, and disease‐specific growth charts remain an important component of growth assessment and should be used along with a nutrition‐focused physical examination. Routine measurement promotes the identification of potential growth delays that may require interventions. Indirect calorimetry adds an additional layer of detail for a complete picture of each infant or child's unique nutrition status and progress. Quality improvement research on a national level is urgently needed to assess the adequacy and availability of resources in neonatal and pediatric critical care units and to further the development of standard clinical outcome measures for nutrition assessment and intervention in the critically ill neonate and child.

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Late Growth and Changes in Body Composition Influence Odds of Developing Retinopathy of Prematurity among Preterm Infants

Cited by 8 publications

References 27 publications

The Effects of Combuxil and Leizumab on Retinal Function and Serum Interleukin-17A in Premature Infants with Retinopathy

The Effects of Combuxil and Leizumab on Retinal Function and Serum Interleukin-17A in Premature Infants with Retinopathy

Modifiable Risk Factors and Preventative Strategies for Severe Retinopathy of Prematurity

Measuring growth in critically ill neonates and children

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