The examination of original and available petrochemical, geochemical, and isotope (Sm-Nd, Rb-Sr) data showed that subalkaline granitoids in the northern framing of the eastern flank of the Mongol–Okhotsk orogenic belt belong to the adakite series. The granitoids are characterized by high Sr/Y, Sr, Al2O3, and LREE, extremely low HREE concentrations, and the absence of negative Eu anomalies. The results obtained and the analysis of the geodynamic setting of their formation made it possible to assume that the granitoids were formed at a depth of more than 45 km through melting of garnet-bearing (20–50% garnet) rocks, which are likely represented by lower crustal Precambrian complexes widespread in the southern framing of the Siberian craton. The source of parental melts involved both mantle and crustal matter. This likely occurred in a subduction setting through melting of frontal or lateral parts of oceanic slab in subduction “windows”. The Late Jurassic–Early Cretaceous Chubachin adakite complex (149–138 Ma) was distinguished. Its formation preceded the initiation of suprasubduction differentiated calc-alkaline magmatism (140–122 Ma) in the northern framing of the eastern flank of the Mongol–Okhotsk orogenic belt.