Late-Life Risk Factors for All-Cause Dementia and Differential Dementia Diagnoses in Women

Neergaard, Jesper Skov; Dragsbæk, Katrine; Hansen, Henrik; Henriksen, Kim; Christiansen, Claus; Karsdal, Morten A.

doi:10.1097/md.0000000000003112

Cited by 30 publications

(41 citation statements)

References 34 publications

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“…Fifteen studies (10 in Europe, 8 10–14 32–35 4 in Northern America 7 9 15 36 and 1 in Africa 37 ) with 37 436 participants for ACD ( table 1 ), 8 studies (4 in Europe 8 10 14 34 and 4 in Northern America 6 7 9 15 ) with 25 031 participants for AD ( table 2 ) and 4 studies (2 in Europe 10 34 and 2 in Northern America 7 15 ) with 16 797 participants for VD were included in the primary analysis. During follow-up (3–31.6 years for ACD, 3.9–31.6 years for AD and 4–11.9 years for VD), at least 2665 (as case number was not given in two studies 11 12 ), 1337 and 343 participants who were not suffering from dementia at baseline were diagnosed with ACD, AD and VD, respectively.…”

Section: Resultsmentioning

confidence: 99%

Leisure time physical activity and dementia risk: a dose-response meta-analysis of prospective studies

et al. 2017

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BackgroundThere is considerable evidence of the favourable role of more physical activity (PA) in fighting against dementia. However, the shape of the dose–response relationship is still unclear.ObjectiveTo quantitatively investigate the relationship between dementia and PA.DesignPubMed, EMBASE, Ovid and the Cochrane Library were searched for prospective studies published from 1 January 1995 to 15 October 2016. Two types of meta-analyses were performed with a focus on the dose–response relationship using two stage generalised least squares regression.ResultsThe primary analysis exhibited a dose–response trend for all-cause dementia (ACD), Alzheimer’s disease (AD) but not for vascular dementia (VD). In the dose–response analysis, either ACD (ptrend <0.005; pnon-linearity=0.87) or AD (p trend <0.005; pnon-linearity=0.10) exhibited a linear relationship with leisure time PA (LTPA) over the observed range (0–2000 kcal/week or 0–45 metabolic equivalent of task hours per week (MET-h/week)). Specifically, for every 500 kcal or 10 MET-h increase per week, there was, on average, 10% and 13% decrease in the risk of ACD and AD, respectively.ConclusionsWe have reported, for the first time, the dose–response relationship between LTPA and dementia, further supporting the international PA guideline from the standpoint of dementia prevention.

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Section: Resultsmentioning

confidence: 99%

Leisure time physical activity and dementia risk: a dose-response meta-analysis of prospective studies

et al. 2017

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“…The Prospective Epidemiological Risk Factor (PERF) study was an observational, prospective study of Danish postmenopausal women. The cohort has been described in details elsewhere[ 11 ]. A total of 5,855 women aged 55–85 were enrolled in the study.…”

Section: Methodsmentioning

confidence: 99%

Two novel blood-based biomarker candidates measuring degradation of tau are associated with dementia: A prospective study

et al. 2018

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BackgroundTruncated tau appears to be specifically related to disease pathology and recent studies have shown the presence and elevation of several truncated tau species in Cerebrospinal fluid (CSF) of subjects with Alzheimer’s disease (AD); however, the relevance of truncated Tau measurements in blood is still being studied.ObjectiveThe aim of the current study was to assess the longitudinal associations between baseline levels of two novel blood biomarker candidates measuring truncated tau, Tau-A and Tau-C, and the risk of incident dementia and AD in elderly women.MethodsUsing solid phase competitive ELISA, two tau fragments were detected in serum of 5,309 women from the Prospective Epidemiological Risk Factor study. The study was an observational, prospective study of Danish postmenopausal women. Subjects were followed with registry-linkage for up to 15 years (median follow-up time 13.7 years). Cox regression was used to assess the utility of the biomarker candidates in relation to dementia and AD.ResultsHigh levels of Tau-A and Tau-C (above the median) in blood were associated with lower risk of dementia and AD (Tau-A: Dementia HR[95% CI] = 0.85[0.70–1.04]; AD 0.71[0.52–0.98] and Tau-C: Dementia 0.84[0.70–1.00]; AD 0.78[0.60–1.03]). Tau-C gave a very modest increase in the AUC in a 5-year prediction horizon as compared to a reference model with age and education, while a combination of the two did not improve their predictive capacity.ConclusionsMeasurement of tau in serum is feasible. The serological tau turnover profile may be related to the diagnosis and development of dementia and AD. The exact processing and profile in serum in relation to cognitive disorders remains to be further assessed to provide simple non-invasive tests to identify subjects with progressive cognitive disorders.

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“…This evaluation is based on the cohort “The Prospective Epidemiological Risk Factor (PERF) Study” which, in a prospective observational design includes Danish postmenopausal women to investigate age-related diseases. A detailed description of the cohort have previously been published 13 , 14 . The PERF study was conducted in accordance with Good Clinical Practice and approved by the Danish National Committee on Health Research Ethics (KA99070gm) with informed consent obtained from all subjects.…”

Section: Methodsmentioning

confidence: 99%

Matrix Metalloproteinase Mediated Type I Collagen Degradation is an Independent Predictor of Increased Risk of Acute Myocardial Infarction in Postmenopausal Women

Bertelsen

Neergaard

Bager³

et al. 2018

Sci Rep

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Acute myocardial infarction (AMI) is often underdiagnosed in women. It is therefore of interest to identify biomarkers that indicate increased risk of AMI and thereby help clinicians to have additional focus on the difficult AMI diagnosis. Type I Collagen, a component of the cardiac extracellular matrix, is cleaved by matrix metalloproteinases (MMPs) generating the neo-epitope C1M. We investigated the association between serum-C1M and AMI and evaluated whether C1M is a prognostic marker for outcome following AMI. This study is based on The Prospective Epidemiological Risk Factor (PERF) Study including postmenopausal women. 316 out of 5,450 women developed AMI within the follow-up period (14 years, median). A multivariate Cox analysis assessed association between serum-C1M and AMI, and re-infaction or death subsequent to AMI. The risk of AMI increased by 18% (p = 0.03) when serum-C1M was doubled and women in the highest quartile had a 33% increased risk compared to those in the low quartiles (p = 0.025). Serum-C1M was, however not related to reinfarction or death subsequent to AMI. In this study C1M was be an independent risk factor for AMI. Measuring MMP degraded type I collagen could be useful for prediction of increased risk of AMI if replicated in other cohorts.

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Late-Life Risk Factors for All-Cause Dementia and Differential Dementia Diagnoses in Women

Abstract: Supplemental Digital Content is available in the text

Cited by 30 publications

References 34 publications

Leisure time physical activity and dementia risk: a dose-response meta-analysis of prospective studies

Leisure time physical activity and dementia risk: a dose-response meta-analysis of prospective studies

Two novel blood-based biomarker candidates measuring degradation of tau are associated with dementia: A prospective study

Matrix Metalloproteinase Mediated Type I Collagen Degradation is an Independent Predictor of Increased Risk of Acute Myocardial Infarction in Postmenopausal Women

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