Late malignant transformation of dormant ganglioneuroma?

Moschovi, Maria; Arvanitis, Dimitrios L.; Hadjigeorgi, Christina; Mikraki, Vasiliki; Tzortzatou‐Stathopoulou, Fotini

doi:10.1002/(sici)1096-911x(199705)28:5<377::aid-mpo11>3.0.co;2-8

Cited by 29 publications

(19 citation statements)

References 19 publications

(13 reference statements)

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“…Ganglioneuromas are commonly asymptomatic, and the development of clinical symptoms depend on the localisation and the size of the tumour. Additionally, because of the malignant transformation of a small number of ganglioneuromas reported in the literature, early diagnosis and complete excision of the tumour is essentially important [1][2][3][4].…”

Section: Introductionmentioning

confidence: 54%

Diagnostic imaging findings of pelvic retroperitoneal ganglioneuroma in a child: a case report with the emphasis on initial ultrasound findings

Demir

et al. 2016

Med Ultrason

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Ganglioneuromas are rare benign tumors of neural crest origin developed along the sympathetic chain. The pelvic retroperitoneum is the rarest location of these tumors. Clinically these tumors are commonly asypmtomatic even if they reach large sizes. Here we report the radiological features of a 16 year old boy with pathologically proven retroperitoneal ganglioneuroma that was detected initially by ultrasound. Relevant literature is also discussed.

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Section: Introductionmentioning

confidence: 54%

Diagnostic imaging findings of pelvic retroperitoneal ganglioneuroma in a child: a case report with the emphasis on initial ultrasound findings

Demir

et al. 2016

Med Ultrason

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“…19 Ganglioneuroma is a welldifferentiated tumor, most commonly seen in children older than 10 years. 20 Interestingly, Moschovi et al 21 and Kulkarni et al 22 described the malignant transformation of dormant ganglioneuroma, and Drago et al 23 reported the spontaneous development of a malignant peripheral nerve-sheath tumor in benign ganglioneuroma. Thus, careful monitoring may be necessary after the resection of benign retroperitoneal tumors.…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic excision of retroperitoneal tumors: Report of three cases

Sasaki

Sakai²,

Nitta

et al. 2010

Surg Today

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Retroperitoneal neural tumors are rarely excised laparoscopically, with fewer than ten cases reported in the literature. Between February 2005 and December 2007, we performed successful planned laparoscopic excision of retroperitoneal tumors using the four-trocar technique in three patients. All three patients were women, with a mean age of 40.7 years. The mean tumor size was 4.8 cm. The mean operative time was 126 min and the mean blood loss 14.3 ml. The postoperative pathological diagnosis was schwannoma in one patient and ganglioneuromas in two. There was no morbidity or mortality. Although difficult to diagnose preoperatively, neural tumors in the retroperitoneal space are most often benign, with a good prognosis. Laparoscopic surgical techniques for retroperitoneal tumors are safe, and their use is encouraged when an appropriate diagnosis is made, after exclusion of malignant subtypes.

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“…There are no clear guidelines that exist to direct the management of incidentally detected ganglioneuromas [12]. Although most primary tumors arising in the mesentery are mesenchymal and histologically benign, some extracranial ganglioneuromas are capable of metastasizing in a small percentage of cases [13,14]. Therefore, surgical removal of the tumor is recommended for a more favorable prognosis.…”

Section: Discussionmentioning

confidence: 99%