The Central Asian Orogenic Belt (CAOB) is the largest accretionary orogenic belt in the world and its formation involved a complicated process of arc–continent collision. Large‐scale Mesozoic volcanic activity in the Great Xing'an Range (GXAR) in northeastern China, which constitutes part of the eastern CAOB, has received much recent research attention. However, the petrogenesis and formation mechanism of the late Mesozoic igneous rocks remain enigmatic. This paper investigates the geochronology, petrogenesis, and formation mechanism of late Mesozoic magmatic rocks in the Kelihe area of the GXAR based on zircon U–Pb dating, petrology, and geochemistry. Late Mesozoic magmatism in the Kelihe area occurred during the Late Jurassic (165–155 Ma) and Early Cretaceous (130–120 Ma). These igneous rocks generated by this magmatism are characterized by high SiO2 (69.97–75.49 wt%) and low MgO (0.11–0.68 wt%), Cr (10–30 ppm), Co (0.2–2.6 ppm), and Ni (0.5–1.6 ppm) contents. Trace elements show enrichment in Rb, Th, U, Zr, and K, and depletion in Ba, P, Nb, and Ti. These features indicate that the rocks were derived from partial melting of the crust. Furthermore, the rhyolites have high Na2O (5.02–5.44 wt%) and K2O (3.94–4.88 wt%) contents, similar to those of melts formed by the partial melting of basaltic crust. Combining the present results with the findings of previous studies, it is inferred that the Mesozoic igneous rocks formed in a post‐collisional extensional setting related to lithospheric thinning and asthenospheric upwelling after the closure of the Mongol–Okhotsk Ocean.