We present a structural study on the tectonic windows of Giffoni and Campagna, located in the western sector of the southern Apennines (Italy). We analyzed thrusts, folds, and related minor deformation structures. Here, a major in-sequence E-verging thrust fault juxtaposes Meso-Cenozoic successions of the Apennine Platform (Picentini Mts unit) and the Lagonegro-Molise Basin (Frigento unit). However, out-of-sequence thrusts duplicated the tectonic pile with the interposition of the upper Miocene wedge-top basin deposits of the Castelvetere Group. We reconstructed the orogenic evolution of these two tectonic windows, including five deformation phases. The first (D1) was related to the in-sequence thrusting with minor thrusts and folds, widespread both in the footwall and the hanging wall. A subsequent extension (D2) has formed normal faults crosscutting the D1 thrusts and folds. All structures were subsequently affected by two shortening stages (D3 and D4), which also deformed the upper Miocene wedge top basin deposits of the Castelvetere Group. We interpreted the D3–D4 structures as related to an out-of-sequence thrust system defined by a main frontal E-verging thrust and lateral ramps characterized by N and S vergences. Low-angle normal faults were formed in the hanging wall of the major thrusts. Out-of-sequence thrusts are observed in the whole southern Apennines, recording a crustal shortening event that occurred in the late Messinian–early Pliocene. Finally, we suggest that the two tectonic windows are the result of the formation of an E–W trending regional antiform, associated with a late S-verging back-thrust, that has been eroded and crosscut by normal faults (D5) in the Early Pleistocene.