ABSTRACT:The study was carried out to investigate the socio-demographic characteristics and co-morbidity of patients suffering from tuberculosis from selected hospitals of Faisalabad and Lahore, Pakistan. A total of 366 patients were included in the study. The ZN microscopy was carried out along with PCR. The socio-demographic characteristics of each patient were recorded along with any comorbidity. All the patients under study were found positive by ZN staining, while, 258 (70.5%) were found positive by PCR. Of these 258 patients, 52% were females and 48% were males. The 36.8% patients were between 16-30 years, 40% had a body weight between 41-50 Kg, 75.6% were married, 51.9% were uneducated, while 41.8% had education up to ten grades, and 38% were housewives. Tuberculosis alone was present in 36.8% cases, while 63.2% patients had other disease conditions as well. Out of 63.2%, 24% had diabetes, 17.8% had hepatitis virus infection, 11.2% had diabetes and hepatitis (HCV) together, 4.2% had HIV infection, 12.3% had both HIV and HCV infections together and 3.4% had myocardial infarction. Among TB patients 52% were females, 75.6% were married and 51.9% uneducated. The 63.2% patients had comorbidity of which 24% had diabetes, 17.8% viral hepatitis, 4.2% HIV and 3.4% myocardial infarction.