Late Oncological Occurrences Following Radical Cystectomy in Patients with Bladder Cancer

Solsona, E.; Iborra, I.; Rubio, José; Casanova, J.; Dumont, R.; Monrós, J.L.

doi:10.1016/s0302-2838(03)00100-3

Cited by 62 publications

(61 citation statements)

References 20 publications

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“…Although the usefulness of surveillance CT scan remains unclear (9, 10), some studies have suggested CT as an imaging modality for routine follow-up (9,11). However, there is only one study that describes imaging findings of recurrent bladder cancer after cystectomy (4), and that study included a relatively small number of patients over a 4-year period.…”

Section: Discussionmentioning

confidence: 99%

Recurrence patterns of bladder transitional cell carcinoma after radical cystectomy

et al. 2012

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Section: Discussionmentioning

confidence: 99%

Recurrence patterns of bladder transitional cell carcinoma after radical cystectomy

et al. 2012

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“…Also, looking at the literature, most evidence suggesting that the distal ureteral involvement is associated with increased risk of upper tract recurrence following cystectomy was provided by studies which analyzed ureteral tissues removed en bloc with bladder during cystectomy rather than those on the results of intraoperative frozen section analysis of ureteral margins [5,13,16] . Meanwhile, Solsona et al [17] reported that most of the late recurrences after cystectomy were observed in the upper tract with multiple tumors, prostate involvement, and organ-confi ned tumors being signifi cant predictive factors. However, patients included in their series were quite different in characteristics from those included in ours, and they did not evaluate margin positivity of ureteral marginal status at cystectomy.…”

Section: Discussionmentioning

confidence: 99%

Significance of Cancer Involvement at the Ureteral Margin Detected on Routine Frozen Section Analysis during Radical Cystectomy

Lee

Byun²,

Hong³

et al. 2006

Urol Int

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Introduction: We investigated the clinical significance of preoperatively-unsuspected ureteral involvement of cancer detected on intraoperative frozen section analysis of ureteral margins during radical cystectomy. Patients and Methods: We performed a retrospective study of 115 patients who received radical cystectomy for locally-advanced but node-negative transitional cell carcinoma of the bladder between 1995 and 2002 by reviewing their records. Results: Of 115 total patients, 5 (4.3%) demonstrated carcinoma in situ at the ureteral margin with 2 of 5 having a positive margin on final pathologic analysis. Meanwhile, only 3 of 115 total patients (2.6%) later showed upper urinary tract recurrence at a median interval of 30 months after cystectomy. And all 3 patients had intramural or juxtavesical ureter involvement of disease (p = 0.006), while not demonstrating carcinoma in situ in ureteral margins resected during cystectomy. On multivariate analysis, only the stage and grade of bladder cancer along with pathologic feature of vascular invasion were observed to be independent prognostic predictors of disease-specific survival. Conclusions: Cancer involvement of the distal ureteral margin detected through intraoperative frozen section analysis may not be a significant factor regarding upper tract recurrence and survival of patients with locally-advanced bladder cancer after radical cystectomy. Upper tract recurrence may be more prone to occur in patients with cancer involvement at the intramural or juxtavesical ureter.

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“…4,7 In our series urothelial recurrence after RC is more commonly seen in conjunction with positive urinary cytology, as noted in 57 of 101 patients. Excluding the 16 patients with metastatic disease treated with chemotherapy we observed that 57 of 85 had urothelial recurrence after positive cytology after RC.…”

Section: Discussionmentioning

confidence: 54%

“…[3][4][5][6] Risk factors for upper tract recurrence have been reported to be distal ureteral involvement at cystectomy, carcinoma in situ and tumor advanced pathological stage. 4,7 Urinary cytology has been routinely used for followup in patients with bladder cancer since its introduction by Papanicolau and Marshall. 8 The usefulness of urinary cytology for evaluating patients with known bladder cancer was recently questioned because assay sensitivity is thought to be high in patients with high grade TCC but poor for low grade TCC.…”

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confidence: 99%

Natural History of Positive Urinary Cytology After Radical Cystectomy

et al. 2006

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Urine cytology may have a valuable role for detecting upper tract recurrence after radical cystectomy. Most patients with positive cytology after radical cystectomy eventually have radiological evidence of urothelial recurrence. These data may help clarify natural history in patients with positive cytology after radical cystectomy. Additionally, these data indicate the need for diligent evaluation for recurrent disease and potentially the role of early adjuvant therapy in patients with positive cytology after radical cystectomy.

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Late Oncological Occurrences Following Radical Cystectomy in Patients with Bladder Cancer

Cited by 62 publications

References 20 publications

Recurrence patterns of bladder transitional cell carcinoma after radical cystectomy

Recurrence patterns of bladder transitional cell carcinoma after radical cystectomy

Significance of Cancer Involvement at the Ureteral Margin Detected on Routine Frozen Section Analysis during Radical Cystectomy

Natural History of Positive Urinary Cytology After Radical Cystectomy

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