Late onset acute pancreatitis in P. falciparum malaria – An adverse reaction to intravenous artesunate?

Mahdi, Asmaa S.; Molai, Mariya; Chandwani, Juhi; Khalili, Huda Al; Ibrahim, Hashim; Pandak, Nenad; Khamis, Faryal; Petersen, Eskild

doi:10.1016/j.idcr.2018.04.010

Cited by 6 publications

(4 citation statements)

References 8 publications

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“…Em nosso estudo, o caso de pancreatite associado a malária ocorreu após o paciente relatar a dor abdominal, juntando o fator epidemiológico (paciente esteve em área de mata) com a sintomatologia sugestível de malária e que teve sua confirmação após os exames laboratoriais. Outras causas comuns de pancreatite aguda, foram excluídas, o paciente não apresentava um histórico de consumo excessivo de álcool, nenhuma evidência de cálculos biliares em exames de imagem abdominal e nenhuma medicação foi justificável para causa da pancreatite (MANDAL et al, 2011;MAHDI et al, 2018;ROY et al, 2020).…”

Section: Discussionunclassified

Pancreatite Aguda Ocasionada Por Malária Falciparum No Estado Do Amazonas: Relato De Caso

De Miranda,

De Albuquerque,

Bulbol

et al. 2024

Rev. Contemp.

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A malária é uma das infecções parasitárias mais comuns em humanos com uma alta taxa de incidência na Índia e pode apresentar um amplo espectro de complicações, como: lesão renal aguda , lesão hepática, envolvimento cerebral, coagulopatia e anemia e a pancreatite aguda, uma complicação rara. No Brasil, a Amazônia, que compreende 9 estados, concentra 99% dos casos diagnosticados de malária, entre esses está o estado do Amazonas. Nesse estudo, relatamos um caso de pancreatite aguda ocasionada por malária Falciparum no estado do Amazonas.

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Section: Discussionunclassified

Pancreatite Aguda Ocasionada Por Malária Falciparum No Estado Do Amazonas: Relato De Caso

De Miranda,

De Albuquerque,

Bulbol

et al. 2024

Rev. Contemp.

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“…Artesunate, like any other artemisinin, inhibits the polymerization of heme, generates ROS, destabilizes the parasite membrane, alkylates proteins, and inhibits PfATP6 [181]. Mahdi AS reported the case of a 34-year-old man with severe malaria who developed AP after 8 days of intravenous administration of artesunate [174][175][176][177][178][179][180][181][182][183][184]. Other causes of AP were ruled out; however, no rechallenge was performed.…”

Section: Artesunatementioning

confidence: 99%

Drug-Induced Acute Pancreatitis in Adults: Focus on Antimicrobial and Antiviral Drugs, a Narrative Review

Del Gaudio,

Covello,

Di Vincenzo

et al. 2023

Antibiotics

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Acute pancreatitis (AP) is an acute inflammation of the pancreas caused by the activation of digestive enzymes in the pancreatic tissue. The main causes of AP are cholelithiasis and alcohol abuse; less commonly, it can be caused by drugs, with a prevalence of up to 5%. Causal associations between drugs and pancreatitis are largely based on case reports or case series with limited evidence. We reviewed the available data on drug-induced AP, focusing on antimicrobial drugs and antivirals, and discussed the current evidence in relation to the classification systems available in the literature. We found 51 suspected associations between antimicrobial and antiviral drugs and AP. The drugs with the most evidence of correlation are didanosine, protease inhibitors, and metronidazole. In addition, other drugs have been described in case reports demonstrating positive rechallenge. However, there are major differences between the various classifications available, where the same drug being assigned to different probability classes. It is likely that the presence in multiple case reports of an association between acute pancreatitis and a drug should serve as a basis for conducting prospective randomized controlled trials to improve the quality of the evidence.

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“…transmitted by female Anopheles mosquitoes [ 24 ]. Although malaria is life-threatening, early diagnosis and appropriate treatment lead to it having an excellent prognosis [ 25 ]. Global data show that around 229 million people are affected by malaria, while about 409,000 succumb to it annually; hence, efforts are needed to prevent and control it [ 26 ].…”

Section: Malaria and Its Parasite Life Cyclementioning

confidence: 99%

“…The pancreatitis was seen as a possible adverse reaction to intravenous ART [ 43 ] after using the adverse drug reaction probability score. Intravenous fluid and pain management led to a rapid response of pancreatitis, and it did not reoccur even up to 2 months post-treatment [ 25 ].…”

Section: Malaria and Its Parasite Life Cyclementioning

confidence: 99%

Recent Advances in the Therapeutic Efficacy of Artesunate

2022

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Artesunate, a semisynthetic artemisinin derivative, is well-known and used as the first-line drug for treating malaria. Apart from treating malaria, artesunate has also been found to have biological activity against a variety of cancers and viruses. It also exhibits antidiabetic, anti-inflammatory, anti-atherosclerosis, immunosuppressive activities, etc. During its administration, artesunate can be loaded in liposomes, alone or in combination with other therapeutic agents. Administration routes include intragastrical, intravenous, oral, and parenteral. The biological activity of artesunate is based on its ability to regulate some biological pathways. This manuscript reports a critical review of the recent advances in the therapeutic efficacy of artesunate.

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Late onset acute pancreatitis in P. falciparum malaria – An adverse reaction to intravenous artesunate?

Cited by 6 publications

References 8 publications

Pancreatite Aguda Ocasionada Por Malária Falciparum No Estado Do Amazonas: Relato De Caso

Pancreatite Aguda Ocasionada Por Malária Falciparum No Estado Do Amazonas: Relato De Caso

Drug-Induced Acute Pancreatitis in Adults: Focus on Antimicrobial and Antiviral Drugs, a Narrative Review

Recent Advances in the Therapeutic Efficacy of Artesunate

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