Late Onset Hyalinosis Cutis et Mucosae

Abstract

Two cases of non-familial, late onset (50 and 62-years-old) hyalinosis cutis et mucosae were studied and compared with classical early onset cases. Late onset cases showed essentially the same histological and ultrastructural features described for early onset cases. The late onset variety should be distinguished from other diseases; they resemble systemic amyloidosis and sometimes the adult form of colloid milium.

Myeloma-associated systemic amyloidosis with an extensive cutaneous involvement

“…[1] Although it is a genetic disease, a few rare late-onset cases have been reported. [4] Strong Congo red staining favored the diagnosis of PSA. Finally, the third differential would be the rare variant of localized cutaneous amyloidosis - nodular or tumefactive form.…”

Hialinose cutaneo-mucosa

“…África do Sul 42 Emsley & Paster, (1985); Friedman et al (1984); ; ; Siebert et al (2003); van Rooy et al (1991) Alemanha 14 Brand et al (2006); Haneke et al (1984);Hulermann et al (2007); Markowitsch et al (1994); Hausser et al (1991); Simon et al (1990); Vago et al (2007) Appenzeller et al (2006); Asseis & Mattos (1984); ; Lima et al (2003); Marone et al (1991); Ramos e Silva (1943); ; Konstantinov et al (1992) Espanha Miguélez et al (2005); Navarro et al (1999); Sangueza et al (1981); Estados Unidos 13 Cowan et al (1961); Dyer et al (2006); Farolan et al (1992); Finkelstein et al (1982); Hashimoto et al (2000); Holme et al (2005); ; Johnson et al (1989); ; Ostrovsky et al (2007); Savagge et al (1988); Tranel & Hyman (1990) França 11 Aubin et al (1989); Bannerot et al (1998); Barthelemy et al (1986); Bravo-Piris et al (1985); Brocheriou et al (1984); Disdier et al (1994); Maruani et al (2007); Payan et al (1984) Reino Unido ; Glover et al (1992); Kelly et al (1989); ;…”