Late-onset hypogonadism: Review of the problem

Požarskis, Anatolijs; Ērenpreiss, Juris

doi:10.2478/v10046-010-0028-3

Cited by 2 publications

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“…On the other hand, chronic diseases can cause testosterone deficiency, or speed up its development. For example, in patients with visceral adiposity, fat cells synthesise biologically active substances, which, being involved in metabolic processes, reduce testosterone synthesis as a result (Butrova, 1999;Poþarskis and Çrenpreiss, 2010). In men with reduced libido or erectile dysfunction, the frequency of sexual intercourse is reduced, which, in turn, increases the testosterone deficiency even more.…”

Section: Discussionmentioning

confidence: 99%

Detection of Late-Onset Hypogonadism in Men with Chronic Internal Diseases

Požarskis

Lejnieks

2019

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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Late-onset hypogonadism (LOH) is a clinical and biochemical syndrome associated with age and featured by typical symptoms and reduced blood testosterone level. Among males aged over 30 years, the incidence of androgen deficiency is 7 to 30%. The aim of this study was to investigate the incidence of hypogonadism in patients aged over 40 years with an underlying condition and/or a comorbidity, such as arterial hypertension, Chronic obstructive pulmonary disease (COPD), metabolic syndrome, Type 2 of diabetes mellitus, dyslipidaemia, adiposity in various General practice (GP) and physician-sexologists’ offices in Latvia, and to determine the influence of chronic diseases on the development of hypogonadism. Males aged 39 years who turned to family doctors at nine GP were offered to fill in Aging Male Study (AMS) questionnaires used for the diagnostics of late-onset hypogonadism. Males aged 40 years who visited the office of the physician sexologist Anatolijs Požarskis were offered to fill in the same questionnaires. After compiling the data from AMS questionnaires, a group of males exhibiting signs of LOH were isolated (in total 1222 persons). In these patients, we determined blood testosterone and sex-hormone binding globulin (SHBG) levels. Chronic diseases were found in these men in data evaluation of patient medical records, and after performing physical and laboratory examinations. Late-onset hypogonadism was laboratory-diagnosed in 79% of patients with signs of late-onset hypogonadism in accordance with the AMS questionnaires and with concomitant diseases and in 4.7% of patients with signs of late-onset hypogonadism in accordance with the AMS questionnaires and without the aforementioned concomitant diseases. Persons with arterial hypertension, dyslipidaemia, adiposity, metabolic syndrome, COPD and Type 2 of diabetes mellitus had higher chance of developing hypogonadism (p < 0.001). Arterial hypertension, dyslipidaemia, adiposity, metabolic syndrome, COPD statistically significantly (p < 0.001) decreased the level of total testosterone by 0.47, 1.18, 0.36, 0.67, and 0.18 ng/ml, respectively, and decreased the level of free testosterone by 2.52, 2.71, 1,69, 6.77, and 4.58 pg/ml, respectively. Type 2 diabetes mellitus had no statistically significant effect on the level of total and free testosterone (p = 0.95, p = 0.10). The most significant decrease in the level of testosterone was observed in cases of dyslipidemia, COPD and metabolic syndrome. General physicians should pay special attention to patients with this disease, as these patients belong to a group with a high risk of development of expressed LOH syndrome.

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Section: Discussionmentioning

confidence: 99%

Detection of Late-Onset Hypogonadism in Men with Chronic Internal Diseases

Požarskis

Lejnieks

2019

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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show abstract

“…On the other hand, chronic diseases can cause testosterone deficiency, or speed up its development. For example, in patients with visceral adiposity, fat cells synthesise biologically active substances, which, being involved in metabolic processes, reduce testosterone synthesis as a result (Butrova, 1999;Požarskis, Ērenpreiss, 2010). In men with reduced libido or erectile dysfunction, the frequency of sexual intercourses is reduced, which, in turn, increases the testosterone deficiency even more.…”

Section: Mutual Interaction Of Loh and Comorbiditiesmentioning

confidence: 99%

Peculiarities of the Development and Diagnosis of Late-Onset Hypogonadism in Men in the Case of Chronic Diseases – Arterial Hypertension, Dyslipidaemia, Adiposity, Metabolic Syndrome, Type 2 Diabetes Mellitus, Chronic Obstructive Pulmonary Disease – and Combinations Thereof. Summary of the Doctoral Thesis

Požarskis¹

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Late-onset hypogonadism: Review of the problem

Abstract: Communicated by Viesturs BaumanisThe study investigates late-onset hypogonadism (LOH)

Cited by 2 publications

References 26 publications

Detection of Late-Onset Hypogonadism in Men with Chronic Internal Diseases

Detection of Late-Onset Hypogonadism in Men with Chronic Internal Diseases

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