Late-onset neonatal sepsis in Arab states in the Gulf region: two-year prospective study

Hammoud, Majeda S.; Al-Taiar, Abdullah; Al-Abdi, Sameer Y.; Bozaid, Hussain; Khan, Anwar; AlMuhairi, Laila M.; Rehman, Moghis Ur

doi:10.1016/j.ijid.2017.01.006

Cited by 34 publications

(48 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study, The case-fatality was 16.8%, which is similar to those reported from Asian countries (16%) [10,20]. E. coli were responsible for about one-third (11/ 34) of deaths due to LOS.…”

Section: Discussionsupporting

confidence: 88%

“…Previous studies have revealed that gram-positive bacteria were the main causative organisms, with CoNS responsible for the most common organism of LOS [18,19]. Majeda et al reported that CoNS alone was responsible for more than one-third of LOS cases in Arab states in the Gulf region [20]. Matthew et al found that for nearly 20 years, CoNS was the organism most responsible for late-onset sepsis in their NICU [21].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Late-onset neonatal sepsis in Suzhou, China

Pan

Zhu

et al. 2020

BMC Pediatr

View full text Add to dashboard Cite

Background: This study aimed to describe the causative organisms of neonatal late-onset sepsis (LOS) and their antimicrobial resistance in Suzhou, Southeast China over a 7-year period. Methods: We performed a retrospective study on neonates with LOS from Jan1, 2011 to Dec 31, 2017. The demographic, clinical, and laboratory data of neonates with LOS were analyzed. Logistic regression was used to investigate the risk factors with mortality. Results: During the study period, 202 neonates with LOS were finally identified. The most common pathogens were Escherichia coli (29.2%), followed by Klebsiella pneumoniae (19.3%), and Coagulase-negative Staphylococcus (CoNS) (16.8%). Nearly 90% of the K. pneumoniae were resistant to cefazolin and 71.8% to ceftazidime. Thirty-four patients (16.8%) died. Multivariable logistic regression showed that significant predictors of mortality were birth weight < 1500 g, respiratory distress and convulsions. Conclusions: Gram-negative organisms have an important role in LOS in our region, with high levels of resistance to third-generation cephalosporins. These data may help in the selection of antibiotics for empirical treatment of neonates with sepsis.

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Late-onset neonatal sepsis in Suzhou, China

Pan

Zhu

et al. 2020

BMC Pediatr

View full text Add to dashboard Cite

show abstract

“…The required demographic, clinical and outcome details, and evidence on possible risk factors for infection were identiﬁed from previously published studies of LOS. 11-14 Neonatal risk factors data collected included the use of mechanical ventilation and duration, total parenteral nutrition (TPN) use and duration, central line use and duration, gestational age, and birth weight. Maternal risk factors included prolonged rupture of membranes (PROM), chorioamnionitis, intrapartum antibiotic prophylaxis (IAP) use, and use of antenatal steroids.…”

Section: Methodsmentioning

confidence: 99%

“…Lack of proper infection control measures and appropriate guidelines in some ICUs in the Gulf region might have a signiﬁcant impact on the increasing incidence of neonatal infections and the outline of causative organisms. 11 In Oman, the incidence, risk factors, and causative organisms of LOS have not been studied comprehensively.…”

Section: Introductionmentioning

confidence: 99%

Outcome of Late-onset Neonatal Sepsis at a Tertiary Hospital in Oman

Abdellatif¹,

Al-Khabori²,

Rahman³

et al. 2019

Oman Med J

View full text Add to dashboard Cite

Objectives We sought to determine the prevalence, pattern of causative organisms, and mortality of newborns with culture-proven late-onset sepsis (LOS) and to determine and compare the risk factors linked to late-onset gram-positive and late-onset gram-negative sepsis in Sultan Qaboos University Hospital (SQUH). Methods We conducted a cross-sectional retrospective study of data obtained between 1 January 2007 and 31 December 2014 (eight years) from infants in the neonatal intensive care unit (NICU) at SQUH. Infants born in SQUH (inborn) and other institutions (outborn) with positive blood cultures were included in the study. Results The total number of live births and admissions during the study period were 26 289 and 3559, respectively. The total number of infants identified with LOS were 125 of whom 69 (55.2%) were gram-positive, 52 (41.6%) were gram-negative, and four (3.2%) were due to Candida species (spp.). The majority of infants (n = 113, 90.4%) were inborn; 69 (55.2%) were males and 56 (44.8%) were females. The prevalence of LOS among inborn admissions was 4.3 per 1000 live births. Most infections occurred in very low birth weight infants (n = 81, 64.8%). Eleven (8.8%) infants died due to gram-negative sepsis. Klebsiella pneumoniae followed by Pseudomonas aeruginosa were the leading cause of death. Maternal intrapartum antibiotics were the only independent risk factor correlating with gram-negative organisms in multivariate analysis ( p = 0.003). Conclusions LOS poses a burden in the NICU, which could be due to the increasing survival of premature babies. The main contributing organisms to LOS are gram-positive bacteria. Klebsiella spp. is a major cause of mortality in LOS. The use of intrapartum antibiotic prophylaxis in mothers might explain the positive correlation of maternal antibiotics as a risk factor with gram-negative infections.

show abstract

“…Studies from some European countries [ 23 ] and Brazil [ 24 ] have documented the contributions of CoNS in neonatal sepsis, which could result in increased risk of mortality and morbidities., There are limited data on the incidence of CoNS in neonatal sepsis in Kuwait [ 25 , 26 ]. However, there are no studies on the molecular characteristics of CoNS associated with neonatal sepsis in Kuwait.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial resistance and virulence determinants in coagulase-negative staphylococci isolated mainly from preterm neonates

Al-Haqan¹,

Boswihi²,

Pathan³

et al. 2020

PLoS ONE

View full text Add to dashboard Cite

Coagulase-negative staphylococci (CoNS) are the most common isolates from blood culture in neonates resulting in high mortality and morbidity. This study investigated CoNS obtained from blood cultures of neonates for antibiotic resistance and virulence factors, and possible association with inflammatory response (C-reactive protein). A total of 93 CoNS isolates were collected from 76 blood cultures of neonates at the Maternity hospital in Kuwait in a six-month period and investigated for susceptibility to antibiotics, carriage of staphylococcal cassette chromosome mec (SCC mec ), and virulence-associated genes. The 93 CoNS isolates consisted of S . epidermidis (76; 81.7%), S . capitis (12; 12.9%), S . hominis (2; 2.1%), S . warneri (2; 2.1%) and S . haemolyticus (1; 1.0%). Eighty-six (92.4%) of the isolates were resistant to cefoxitin (MR-CoNS) while 49 (52.7%) expressed multi-antibiotic resistance. The methicillin-resistant isolates (MR-CoNS) carried SCC mec III, SCC mec IVa and four combinations of SCC mec types including SCC mec types I+IVa (one S . warneri and 25 S . epidermidis isolates), types I+III (one S . epidermidis isolate), types III+IVa (six S . epidermidis isolates) and types I+III+IVa (one S . epidermidis isolate). The most common virulence-related genes were icaC , seb , arc detected in 69.7%, 60.5%, 40.8% of the isolates respectively. Two isolates were positive for tst1 . No association between C-reactive protein and antibiotic resistance or virulence factors was established. This study revealed that S . epidermidis carrying different SCC mec genetic elements, was the dominant CoNS species isolated from neonatal blood cultures with 90.3% and 36.6% of the isolates positive for genes for biofilm and ACME production respectively.

show abstract

Late-onset neonatal sepsis in Arab states in the Gulf region: two-year prospective study

Cited by 34 publications

References 38 publications

Late-onset neonatal sepsis in Suzhou, China

Late-onset neonatal sepsis in Suzhou, China

Outcome of Late-onset Neonatal Sepsis at a Tertiary Hospital in Oman

Antimicrobial resistance and virulence determinants in coagulase-negative staphylococci isolated mainly from preterm neonates

Contact Info

Product

Resources

About