Late Onset of Corneal Scar After Excimer Laser Photorefractive Keratectomy

Meyer, J; Stulting, R. Doyle; Thompson, Keith P.; Durrie, Daniel S.

doi:10.1016/s0002-9394(14)75427-3

Cited by 44 publications

(17 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…One type of haze appears after 1–3 months and is rarely associated with symptoms; it typically disappears about 1 year after the surgery 55. Another type of haze, reported by Meyer et al 56 and Lipshitz et al ,57 is defined as ‘late-onset corneal haze’ (LOCH) and tends to appear from 2–5 months after surgery and persist for more than 3 years until it disappears. Following LASIK, a circumferential haze can be observed that follows the edge of the flap; this is due to rupture of the basal membrane that occurs at the edge of the flap.…”

Section: Corneal Hazementioning

confidence: 99%

Corneal wound healing after laser vision correction

2015

View full text Add to dashboard Cite

Any trauma can trigger a cascade of responses in tissues, with the purpose of safeguarding the integrity of the organ affected by the trauma and of preventing possible damage to nearby organs. Subsequently, the body tries to restore the function of the organ affected. The introduction of the excimer laser for keratorefractive surgery has changed the treatment landscape for correcting refractive errors, such as myopia, hyperopia, and astigmatism. In recent years, with the increased understanding of the basic science of refractive errors, higher-order aberrations, biomechanics, and the biology of corneal wound healing, a reduction in the surgical complications of keratorefractive surgery has been achieved. The understanding of the cascade of events involved in the corneal wound healing process and the examination of how corneal wound healing influences corneal biomechanics and optics are crucial to improving the efficacy and safety of laser vision correction

show abstract

Section: Corneal Hazementioning

confidence: 99%

Corneal wound healing after laser vision correction

2015

View full text Add to dashboard Cite

show abstract

“…Late onset corneal haze (LOCH) is described after PRK with incidence of 0.6-4% [11][12][13]. LOCH after PRK usually appears 4 months after surgery with peaked mean time of 7.4 months [12].…”

Section: Discussionmentioning

confidence: 99%

Late Onset Flap Scarring After Laser in Situ Keratomileusis

Orucoglu

2011

J Med Cases

View full text Add to dashboard Cite

A 55 year old man had uneventful simultaneous LASIK. Seven months postoperatively, the patient came with complaints of a decrease in vision, photophobia, tearing, discomfort, and red eye during the last 2 weeks in the left eye. Suspicion was foreign body hit. Despite steroid treatment, the clinical outcome didn't improve. Eight months postoperatively, slit-lamp examination revealed thinning and scarring in the center of the fl ap in the central cornea. The left eye's best corrected visual acuity was 20/32. The patient underwent a surgical procedure of trephining of the scarred fl ap and using Mitomycin C 0.02%. At the fi nal examination after 18 months the BCVA was 20/25. This is the fi rst report on late central corneal scarring after LASIK. Trephinization of the scarred fl ap can restore visual acuity.

show abstract

“…1,2 Clinically significant haze occurs in 0.5% to 5.0% of cases. 3,4 Studies 5,6 have shown that corneal haze is associated with the activation, migration, and differentiation of stromal keratocytes to corneal myofibroblasts that markedly scatter light and are seen as brightly reflecting cells by in vivo confocal microscopy. Myofibroblast differentiation is also known to be caused by the release of transforming growth factor-β (TGF-β), which leads to down regulation of keratocyte crystallin protein expression of transketolase and aldehyde dehydrogenase 3A1/1A1, which is thought to regulate stromal cell light scattering.…”

mentioning

confidence: 99%

Reducing peak corneal haze after photorefractive keratectomy in rabbits: Prednisolone acetate 1.00% versus cyclosporine A 0.05%

Nien

Flynn

Chang

et al. 2011

Journal of Cataract and Refractive Surgery

View full text Add to dashboard Cite

PURPOSE To compare the effects of topical cyclosporine A 0.05% (Restasis) with those of prednisolone acetate 1.00% (Pred Forte) on corneal haze after photorefractive keratectomy (PRK). SETTING Gavin Herbert Eye Institute, University of California, Irvine–Orange, California, USA. DESIGN Experimental study. METHODS After −9.00 diopter PRK, 15 rabbits were divided into 3 groups and treated for 4 weeks with prednisolone acetate 1.00% or cyclosporine A 0.05% or neither (control). Corneal haze was measured by in vivo confocal microscopy preoperatively and 2, 4, 6, 8, and 12 weeks postoperatively. At 12 weeks, the corneas were evaluated for collagen organization by ex vivo 2-photon second-harmonic generation and stromal cell density. RESULTS Corneal haze was significantly less in the prednisolone acetate group than in the cyclosporine and control groups during the first 6 weeks postoperatively (P < .02). At 8 weeks, there was no significant difference between the 3 groups. There was no significant difference in haze between the cyclosporine group and control group at any time. The stroma was also significantly thinner in the prednisolone acetate group than in the other groups for the first 4 weeks postoperatively (P < .02). Second-harmonic generation scar thickness measurements at 12 weeks were not significantly different between the groups, although the prednisolone acetate group tended to have lower stromal cell density. CONCLUSION Cyclosporine A 0.05% had no effect on wound healing after PRK, while prednisolone acetate 1.00% significantly reduced peak corneal haze but had no effect on long-term corneal haze after discontinuation of the drug.

show abstract

Late Onset of Corneal Scar After Excimer Laser Photorefractive Keratectomy

Cited by 44 publications

References 25 publications

Corneal wound healing after laser vision correction

Corneal wound healing after laser vision correction

Late Onset Flap Scarring After Laser in Situ Keratomileusis

Reducing peak corneal haze after photorefractive keratectomy in rabbits: Prednisolone acetate 1.00% versus cyclosporine A 0.05%

Contact Info

Product

Resources

About