Late-Onset PANDAS Syndrome with Abdominal Muscle Involvement

Martinelli, Paolo; Ambrosetto, G.; Minguzzi, Elena; Battaglia, Simone; Rizzo, Giovanni; Scaglione, Cesa

doi:10.1159/000064960

Cited by 12 publications

(7 citation statements)

References 11 publications

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“…This variety of presentations is consistent with PANDAS literature as case reports describe patients with anorexic tendencies, ADHD, and movement disorders as well as varying degrees of OCD severity, often requiring more than one medication. [16][17][18] If OCD in PANDAS patients is infection-triggered, it is unclear why many patients respond to SS-RIs. It is known that cells inflamed by infection release cytokines, causing further cell damage.…”

Section: Discussionmentioning

confidence: 99%

Varied Presentation of Pandas: A Case Series

Chmelik

Awadallah

Hadi

et al. 2004

Clin Pediatr (Phila)

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Section: Discussionmentioning

confidence: 99%

Varied Presentation of Pandas: A Case Series

Chmelik

Awadallah

Hadi

et al. 2004

Clin Pediatr (Phila)

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“…[106][107][108] Bodner et al reported explosive onset of obsessive-compulsive symptoms in a 25-year-old man following severe streptococcal pharyngitis. [106][107][108] Bodner et al reported explosive onset of obsessive-compulsive symptoms in a 25-year-old man following severe streptococcal pharyngitis.…”

Section: Adult Onsetmentioning

confidence: 99%

“…There have been several reports of PANDAS in adults. [106][107][108] Bodner et al reported explosive onset of obsessive-compulsive symptoms in a 25-year-old man following severe streptococcal pharyngitis. 106 The patient had serologic studies, anti-basal ganglia antibodies, and radiologic findings similar to what have been found in patients with PANDAS.…”

Section: Adult Onsetmentioning

confidence: 99%

Topical Review: Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infection: Sydenham Chorea, PANDAS, and PANDAS Variants

et al. 2006

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Streptococcal infection in children is usually benign and self-limited. In a small percentage of children, prominent neurologic and/or psychiatric sequelae can occur. Sydenham chorea is the best defined and best recognized. PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection) is a well-defined syndrome in which tics (motor and/or vocal) and/or obsessive-compulsive disorder consistently exacerbate in temporal correlation to a group A beta-hemolytic streptococcal infection. PANDAS constitutes a subset of children with tics, Tourette syndrome, and obsessive-compulsive disorder. In addition to strictly defined PANDAS, we and others have recognized several PANDAS variants, including adult-onset variant, a dystonic variant, a myoclonic variant, and a "chronic" PANDAS variant. The nosology and classification of these entities are rapidly evolving. The recognition that some pediatric neurobehavioral syndromes have infectious and/or immunologic triggers points to important new avenues of disease treatment. In this review, we summarize this complex and rapidly evolving area of clinical research.

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“…PANDAS inclusion criteria were outlined that require the presence of OCD and/or tic disorder, prepubertal symptom onset, sudden onset or episodic course of symptoms, temporal association between streptococcal infections and neuropsychiatric symptom exacerbations, and associated neurological abnormalities. Though PANDAS-criteria require prepubertal symptom onset, cases with adult-onset symptoms that otherwise meet PANDAS criteria have been described [98,99]. The concept of PANDAS strongly centers on Sydenham's chorea as a putative disease model, including the suggested pathogenic role of autoantibodies that cross-react with brain antigens as a hypothesized consequence of structural homology with streptococcal antigens [100].…”

Section: Possible Role Of Infections In Tic Disordersmentioning

confidence: 99%

Neurobiology and neuroimmunology of Tourette?s syndrome: an update

Hoekstra¹,

Gm²,

Limburg

et al. 2004

Cellular and Molecular Life Sciences (CMLS)

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Tourette's syndrome is a childhood-onset neuropsychiatric disorder characterized by the presence of both multiple motor and vocal tics. While the pathogenesis at a molecular and cellular level remains unknown, structural and functional neuroimaging studies point to the involvement of the basal ganglia and related cortico-striato-thalamo-cortical circuits as the neuroanatomical site for Tourette's syndrome. Moreover, Tourette's syndrome has a strong genetic component, and considerable progress has been made in understanding the mode of transmission and in identifying potential genomic loci. Summaries of recent findings in these areas will be reviewed, followed by a critical overview of findings both supporting and challenging the proposed autoimmune hypothesis of Tourette's syndrome. We conclude that Tourette's syndrome is a heterogeneous disorder, and that immune factors may indeed be involved in some patients.

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Late-Onset PANDAS Syndrome with Abdominal Muscle Involvement

Cited by 12 publications

References 11 publications

Varied Presentation of Pandas: A Case Series

Varied Presentation of Pandas: A Case Series

Topical Review: Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infection: Sydenham Chorea, PANDAS, and PANDAS Variants

Neurobiology and neuroimmunology of Tourette?s syndrome: an update

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