Late-onset pneumatosis cystoides intestinalis associated with non-infectious pulmonary complications after allogeneic hematopoietic stem cell transplantation

Suzuki, Hiroshi; Izutsu, Koji; Watanabe, Takuro; Oshima, Kiyohiro; Kanda, Yoshinobu; Motokura, Toru; Kurokawa, Mineo

doi:10.1007/s12185-008-0110-7

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…Thereafter, PI worsened after FEAM conditioning for the auto-HSCT. The decision to proceed to the second transplant with an unrelated donor was of particular concern due to the risk of a further worsening of the PI, especially in the possible case of an intestinal GVHD or of infectious complications [5][6][7]12,13]. However, considering the poor prognostic likelihood of our patient affected by DLBCL resistant to several lines of therapy, we decided to proceed with an allo-HSCT, sharing the decision with the patient and her relatives.…”

Section: Discussionmentioning

confidence: 99%

“…It has been associated with congenital disorders, collagen vascular diseases, acquired immunodeficiency, infection, endoscopic procedures, steroid use and chemotherapy [4][5][6][7][8]. PI is also found in association with organ transplantation and HSCT due to pre-transplant chemotherapy, infections and GVHD after HSCT [9][10][11][12][13]. It is hypothesized that when a pathogenic noxa causes a GI wall disruption necrosis, an increased wall permeability can occur, leading to gas infiltration.…”

Section: Introductionmentioning

confidence: 99%

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Is pneumatosis intestinalis a contraindication to allogeneic hemopoietic stem cell transplantation?

Ferretti¹,

Perrone²,

Torelli³

et al. 2016

Trends in Transplant

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Pneumatosis intestinalis (PI) has been described as a possible complication after allogeneic stem cell transplantation (HSCT) due to graft-versus-host disease (GVHD) or infections. So far, no patient with a pre-existent PI who underwent HSCT has been reported. We describe the case of a patient with Alk-negative anaplastic large B-cell lymphoma (DLBCL anaplastic) and PI who successfully received a HSCT from an unrelated donor without complications. This case suggests that this gastrointestinal condition should not be considered an absolute contraindication for an allotransplant procedure.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Is pneumatosis intestinalis a contraindication to allogeneic hemopoietic stem cell transplantation?

Ferretti¹,

Perrone²,

Torelli³

et al. 2016

Trends in Transplant

View full text Add to dashboard Cite

show abstract

“…The gas is thought to come from the intraluminal gastrointestinal system, bacterial production, or a pulmonary source [ 3 ]. Besides chemotherapy, PI is associated with various medical conditions, such as collagen-vascular diseases, lupus enteritis, infectious colitis, asthma, acquired immune deficiency syndrome, cystic fibrosis, hematopoietic stem cell transplantation, trauma, and steroid therapy [ 2 – 4 ]. Compared with cytotoxic agents, PI due to molecular-targeted agents is even rarer [ 1 , 5 – 12 ], and only several cases have been reported in association with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) [ 1 , 13 – 17 ].…”

Section: Introductionmentioning

confidence: 99%

Gefitinib successfully administered in a lung cancer patient with leptomeningeal carcinomatosis after erlotinib-induced pneumatosis intestinalis

et al. 2018

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BackgroundPneumatosis intestinalis (PI) is a rare complication of chemotherapy, characterized by multiple gas accumulations within the bowel wall.Case presentationA 71-year-old woman with epidermal growth factor receptor (EGFR) mutation-positive lung adenocarcinoma was admitted to our hospital because of reduced consciousness. She was diagnosed as having leptomeningeal carcinomatosis (LM) using lumbar puncture. Because she could not swallow a tablet, erlotinib was administered via a feeding tube. Her state of consciousness gradually improved, but she experienced diarrhea several times a day. After 3 weeks of erlotinib therapy, PI occurred. Erlotinib was discontinued and PI was resolved after treatment with conservative therapies. Erlotinib was re-administrated and PI occurred again. After improvement of erlotinib-induced PI, gefitinib was administered by a feeding tube and the patient did not experience PI or diarrhea. The patient survived 8 months from the diagnosis of LM.ConclusionPI is one of the side effects of erlotinib, and consecutive therapies are useful for the treatment of PI. In this patient, gefitinib was successfully administered after erlotinib-induced PI.

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Incidence, risk factors, and outcome of pneumatosis intestinalis in pediatric stem cell transplant recipients

Korhonen

Lovvorn

Koyama

et al. 2011

Pediatric Blood & Cancer

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Late-onset pneumatosis cystoides intestinalis associated with non-infectious pulmonary complications after allogeneic hematopoietic stem cell transplantation

Cited by 4 publications

References 10 publications

Is pneumatosis intestinalis a contraindication to allogeneic hemopoietic stem cell transplantation?

Is pneumatosis intestinalis a contraindication to allogeneic hemopoietic stem cell transplantation?

Gefitinib successfully administered in a lung cancer patient with leptomeningeal carcinomatosis after erlotinib-induced pneumatosis intestinalis

Incidence, risk factors, and outcome of pneumatosis intestinalis in pediatric stem cell transplant recipients

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