Late-onset primary antiphospholipid syndrome in the elderly: a report of seven cases

Chérif, Y.; Jallouli, M.; Hriz, H.; Gouiaa, R.; Marzouk, S.; Snoussi, M.; Frikha, F.; Masmoudi, Hatem; Bahloul, Z.

doi:10.1111/1756-185x.12494

Cited by 4 publications

(3 citation statements)

References 20 publications

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“…Schwangerschaftswoche [ 3 ]. Das mittlere Alter zu Beginn der auf die Krankheit zurückzuführenden Symptome liegt bei 32 Jahren [ 3 ]; Erstmanifestationen im höheren Alter sind selten [ 4 , 5 ]. Während in jungen Studienkohorten vornehmlich Frauen [ 6 ] betroffen sind, sind es bei Erstmanifestationen im Alter häufiger Männer [ 5 ].…”

Section: Diskussionunclassified

Geriatric patient with neurological symptoms and prolonged aPTT

Atakanova,

Heiligers,

Kirschner

et al. 2023

Innere Medizin

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ZusammenfassungEin 73-jähriger Mann mit vorbekannter demenzieller Entwicklung wurde mit Hypernatriämie bei Volumendepletion aufgenommen. Ursächlich dafür zeigte sich eine neue neurogene Schluckstörung, bei Z. n. mehreren Schlaganfällen bestand eine Halbseitensymptomatik. Bei der Sichtung der Unterlagen vorangegangener Krankenhausaufenthalte fiel wiederholt eine verlängerte aPTT (aktivierte partielle Thromboplastinzeit) auf; bereits fünf Jahre zuvor bestand ambulant der Verdacht auf ein Antiphospholipidantikörpersyndrom (APS), ohne dass die Diagnostik komplettiert worden wäre. Wir haben die Diagnose eines primären APS gestellt und eine Antikoagulation mit Vitamin-K-Antagonisten und ASS (Acetylsalicylsäure) begonnen.

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Section: Diskussionunclassified

Geriatric patient with neurological symptoms and prolonged aPTT

Atakanova,

Heiligers,

Kirschner

et al. 2023

Innere Medizin

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“…The overall prevalence of APS has been estimated as 50/10,000, with age of onset typically in the range 20–50 years. However, a proportion of patients present with late onset APS, typically over the age of 65 years [ 70 ]. Mitochondrial dysfunction, oxidative stress and inflammation have been implicated in the pathogenesis of APS [ 71 , 72 , 73 ].…”

Section: Late Onset Antiphospholipid Syndromementioning

confidence: 99%

Coenzyme Q10: Role in Less Common Age-Related Disorders

Mantle

Hargreaves

2022

Antioxidants

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In this article we have reviewed the potential role of coenzyme Q10 (CoQ10) in the pathogenesis and treatment of a number of less common age-related disorders, for many of which effective therapies are not currently available. For most of these disorders, mitochondrial dysfunction, oxidative stress and inflammation have been implicated in the disease process, providing a rationale for the potential therapeutic use of CoQ10, because of its key roles in mitochondrial function, as an antioxidant, and as an anti-inflammatory agent. Disorders reviewed in the article include multi system atrophy, progressive supranuclear palsy, sporadic adult onset ataxia, and pulmonary fibrosis, together with late onset versions of Huntington’s disease, Alexander disease, lupus, anti-phospholipid syndrome, lysosomal storage disorders, fibromyalgia, Machado-Joseph disease, acyl-CoA dehydrogenase deficiency, and Leber’s optic neuropathy.

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“…Outro estudo realizado em um hospital universitário na Tunísia, mostrou uma incidência no diagnóstico de SAAF de 11% em população mais idosa, constituindo um grupo de 7 dentre os 62 pacientes estudados. Destes, 5 eram mulheres, com idade média de 77+/-6 anos, todos estes portadores de evento trombótico vascular 6 . Chama a atenção o fato de que em nenhum destas três publicações está descrito o acometimento oftalmológico com eventos de trombose vascular retiniana.…”

Section: Introductionunclassified