Late-onset Tacrolimus-associated Cerebellar Atrophia in a Heart Transplant Recipient

Kaczmarek, Ingo; Schmauß, Daniel; Sodian, Ralf; Beiras-Fernandez, A.; Oberhoffer, Martin; Daebritz, Sabine; Schoenberg, Stefan O.; Reichart, Bruno

doi:10.1016/j.healun.2006.10.008

Cited by 15 publications

(7 citation statements)

References 14 publications

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“…17,23,25 Some neurologic findings after transplantation may be due to tacrolimus toxicity and associated cerebellar symptoms. 44,45 It is also unclear whether hydration/caloric support was provided during catabolic stress in some reports of neurological deterioration. 17,25 None of our patients have had neurologic deterioration after transplantation.…”

Section: Discussionmentioning

confidence: 99%

Treatment of Methylmalonic Acidemia by Liver or Combined Liver-Kidney Transplantation

Niemi

Kim

Krueger

et al. 2015

The Journal of Pediatrics

101

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Section: Discussionmentioning

confidence: 99%

Treatment of Methylmalonic Acidemia by Liver or Combined Liver-Kidney Transplantation

Niemi

Kim

Krueger

et al. 2015

The Journal of Pediatrics

101

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“…Third, the patient can be converted to a calcineurin inhibitor-free immunosuppressive regimen. For example, the tacrolimus can be switched to sirolimus or everolimus or the patient can receive monthly infusion of belatacept 6 13 19…”

Section: Treatmentmentioning

confidence: 99%

Tacrolimus-induced encephalopathy and polyneuropathy in a renal transplant recipient

Weng

Balaraman

2013

BMJ Case Reports

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Tacrolimus is an immunosuppressant frequently used following solid organ transplantation, including renal transplantation. Peripheral neuropathy is an uncommon neurological side effect of tacrolimus and has rarely been reported in renal transplantation. We report a patient who received a living-related donor kidney transplant and presented with altered mental status and new-onset bilateral foot drop. Laboratory tests including cerebrospinal fluid tests excluded infection, and MRI of the brain showed chronic microvascular ischaemic changes. Electromyography and nerve conduction study confirmed bilateral common peroneal nerve demyelination. He was also found to have inadvertently overdosed on tacrolimus at home. After switching from tacrolimus to cyclosporine, the patient's symptoms improved within 5 months. His renal function was maintained with an immunosuppressant regimen of cyclosporine, prednisone and mycophenolic acid. The prompt recognition of tacrolimus as a potential neurotoxic drug in a patient with renal transplant and substituting tacrolimus with a different immunosuppressant may prevent permanent neurological damage.

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“…Unfortunate, our patient did not improve after tacrolimus was replaced by rapamycin. Switching to CIN-free immunosuppression, for example, sirolimus and mycophenolate mofetil, might have been equally or more effective alternative to manage tacrolimusinduced neurotoxicity [2][3][4].…”

Section: Discussionmentioning

confidence: 99%

BK virus-induced acute motor-axonal polyneuropathy in a renal transplant patient

et al. 2015

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Neurological complications are not uncommon in patients with renal transplantation, mostly affecting the central nervous system, and less frequently the peripheral nerves. BK virus infection is relatively common in transplant recipients and in some cases may lead to neurological complications. In this report, we present an interesting case of a patient who developed acute axonal motor polyneuropathy in the course of BK virus infection 3 months after kidney transplantation. After BK virus clearence in blood, a significant improvement was noted in her polyneuropathy. In patients with acute axonal motor polyneuropathy after transplantation BK virus-induced polyneuropathy should be excluded.

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Late-onset Tacrolimus-associated Cerebellar Atrophia in a Heart Transplant Recipient

Cited by 15 publications

References 14 publications

Treatment of Methylmalonic Acidemia by Liver or Combined Liver-Kidney Transplantation

Treatment of Methylmalonic Acidemia by Liver or Combined Liver-Kidney Transplantation

Tacrolimus-induced encephalopathy and polyneuropathy in a renal transplant recipient

BK virus-induced acute motor-axonal polyneuropathy in a renal transplant patient

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