Late‐Phase Allergy and Eustachian Tube Dysfunction

Abstract

These findings demonstrate that late-phase allergy leads to significant eustachian tube dysfunction and subsequent formation of effusion by impairing the ventilatory and clearance functions of the eustachian tube.

Laser Eustachian Tuboplasty: Two‐Year Results

“…Tubal dysfunction appears to occur most commonly from functionally “obstructive disorders” 8 in which the tube is not anatomically blocked, but there is sufficient bulky mucosal disease that dilation does not occur adequately to aerate the middle ear. The etiology of the mucosal disease remains uncertain, but there is increasing evidence that allergic disease, 7,15 LPR, 5,6 adenoid hypertrophy impinging on the posterior cushion, 16 and anatomic factors, 17 may play important roles. Additionally in children, exposure to tobacco smoke, wood and charcoal smoke, short‐term breast feeding, and overcrowded living conditions 18 correlate with a higher incidence of otitis media.…”

“…Eustachian tube (ET) dysfunction is a common problem of childhood, which may persist into adult life. The cause may be chronic infection, allergies, laryngopharyngeal reflux, primary mucosal disease, abnormalities of the dilation mechanism, and anatomic obstruction 1–8 . When tubal dysfunction is refractory to medical therapy, ventilation tube insertion into the tympanic membrane can be effective in aerating the middle ear.…”

The role of immunomodulatory oligonucleotides in prevention of OVA-induced Eustachian tube dysfunction

“…This procedure has been described previously [18,28]. Briefly, while under anesthesia with a xylazine/ketamine mixture, subjects were placed in the lateral recumbent position.…”

“…He further postulated that the nasal allergic response in patients predisposed them to ETobstruction caused by mediators of inflammation and cytokines released by mucosal mast cells, inflammatory cells, and epithelial cells in the nose and nasopharynx [10]. There is support for this theory that allergy-induced inflammation of the middle ear mucosa and Eustachian tube leads to dysfunction and ultimately to OME [17][18][19][20]. In Sweden, infants with allergy symptoms were found five times more likely to develop OME than non-allergic children [21].…”

Laser Eustachian Tuboplasty: A Preliminary Report

“…The cause or origin of this dysfunction appears to be multifactorial and may include chronic infection, allergic disease, laryngopharyngeal reflux, primary mucosal inflammatory disease, abnormalities with the dilatory dynamics, and anatomical obstructive abnormalities. 1–8 …”