Late post-learning participation of entorhinal cortex in memory processes

Gauthier, M.; Destrade, Claude; Soumireu-Mourat, Bernard

doi:10.1016/0006-8993(82)91201-x

Cited by 26 publications

(9 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The role of the entorhinal cortex in learning and memory has been analyzed in many studies in the mouse Soumireu-Mourat, 1981, 1984;Gauthier et al, 1982Gauthier et al, , 1983Cho et al, 1993;Cho and Jaffard, 1995;Hardman et al, 1997). However, in contrast to the rat, few studies have analyzed the effects of hippocampal lesions in the mouse (Ammasari-Teule et al, 1992).…”

Section: Hippocampal Functionsmentioning

confidence: 95%

The entorhinal cortex of the mouse: Organization of the projection to the hippocampal formation

2002

View full text Add to dashboard Cite

The origin and the terminations of the projections from the entorhinal cortex to the hippocampal formation of the mouse (C57BL/6J strain) have been studied using anterogradely and retrogradely transported tracers. The entorhinal cortex is principally divided into two areas, the lateral entorhinal area (LEA) and the medial entorhinal area (MEA). LEA is the origin of the lateral perforant path that terminates in the outer one-third of the molecular layer of the dentate gyrus, and MEA is the origin of the medial perforant path that ends in the middle one-third of the molecular layer of the dentate gyrus. This projection is mostly to the ispsilateral dentate gyrus; only a few labeled axons and terminals are found in the contralateral dentate gyrus. The projection to the dentate gyrus originates predominantly from neurons in layer II of the entorhinal cortex. The entorhinal cortex also projects to CA3 and CA1 and to subiculum; in both CA3 and CA1, the terminals are present in stratum lacunosum-moleculare, whereas in the subiculum the terminals are in the outer part of the molecular layer. The projection from the entorhinal cortex to CA3, CA1, and subiculum is bilateral, and it originates predominantly from neurons in layer III, but a small number of neurons in the deeper layers of the entorhinal cortex contributes to this projection. The projection of entorhinal cortex to the hippocampus is topographically organized, neurons in the lateral part of both LEA and MEA project to the dorsal part (i.e., septal pole) of the hippocampus, whereas the projection to the ventral (i.e., temporal pole) hippocampus originates from neurons in medial parts of the entorhinal cortex.

show abstract

Section: Hippocampal Functionsmentioning

confidence: 95%

The entorhinal cortex of the mouse: Organization of the projection to the hippocampal formation

2002

View full text Add to dashboard Cite

show abstract

“…Various experiments have suggested that during the post-learning period, a number of cerebral structures participate in memory formation in a differential time-dependent manner (Destrade et al, 1985;Bontempi et al, 1996;Izquierdo & Medina, 1997). In our operant paradigm, a number of previous studies using either electrophysiological or the [ 14 C]2-deoxyglucose metabolic techniques have suggested a sequential temporal intervention of a set of limbic, subcortical and cortical structures during the post-learning period (Destrade et al, 1985(Destrade et al, , 1992Gauthier et al, 1982;Sif et al, 1991).…”

Section: Introductionmentioning

confidence: 91%

Differential learning‐stage dependent patterns of c‐Fos protein expression in brain regions during the acquisition and memory consolidation of an operant task in mice

Bertaina-Anglade

Tramu

Destrade

2000

Eur J of Neuroscience

Self Cite

View full text Add to dashboard Cite

The present study analysed the effects of the stage of learning of an appetitive operant conditioning task on the spatial and temporal patterns of c-Fos protein levels in the brain of BALB/c mice. c-Fos levels were assessed by immunohistochemistry at either 60, 120 or 180 min after either the first, the second or the fifth daily training session and compared to sham animals. The results show an increase of c-Fos-positive nuclei in several subcortical and cortical brain regions, 60-min post-acquisition. Because these activations were a function of task mastery, the data indicate that they were specifically related to learning. Following the first acquisition session, significant increases in c-Fos-positive neurons were observed in the dorsal hippocampus (CA3), anterior cingulate, occipital and parietal cortices. Following the second daily training session, c-Fos was highly expressed in some subcortical regions, the hippocampus, the subiculum, the entorhinal, and posterior cingulate areas. Moreover, a significant correlation was found between the progression of performance from day 1 to day 2 and c-Fos expression on the hippocampal CA1 subfield. Following complete acquisition, no further task-dependent increases in c-Fos-labelled nuclei was observed in any brain region sampled, suggesting that the intervention of c-Fos-induced mechanisms in the consolidation process were terminated. The training stage-dependent changes in regional post-training c-Fos expression in the hippocampus and the connected limbic regions suggest that this neuronal network is actively engaged in memory consolidation processes.

show abstract

“…Especially in the rat, the role of the entorhinal cortex in learning and memory functions has been analyzed in many studies (e.g., Hagan et al, 1992;Jaffard and Meunier, 1993;Holscher and Schmidt, 1994;Pouzet et al, 1999). In contrast, few studies have been done in the mouse (Cho et al, 1993;Cho and Jaffard, 1995;Soumireu-Mourat, 1981, 1984;Gauthier et al, 1982Gauthier et al, , 1983Hardman et al, 1997). Taken together with the fact of the growing use of transgenic mice in studies of learning and memory, and especially the use of transgenic mice in studies of Alzheimer's disease, the lack of detailed anatomical information on the entorhinal cortex and its connections in the mouse led us to this series of studies.…”

Section: Introductionmentioning

confidence: 94%

Entorhinal cortex of the mouse: Cytoarchitectonical organization

Groen

2001

Hippocampus

View full text Add to dashboard Cite

The present study describes the cytoarchitectonical and chemoarchitectonical organization of the entorhinal cortex of the mouse (C57BL/6J strain). The entorhinal cortex is medially bordered by the parasubiculum, and laterally by the perirhinal cortex; rostrally and medially it is bordered by the piriform cortex, whereas caudally and dorsally it is bordered by the postrhinal cortex. The entorhinal cortex is divided into two main areas, i.e., the lateral entorhinal area (LEA) and the medial entorhinal area (MEA). Both entorhinal areas are further divided into subfields, i.e., LEA is divided into DLE (dorsolateral entorhinal field), DIE (dorsal intermediate entorhinal field), and VIE (ventral intermediate entorhinal field), whereas MEA is divided into CE (caudal entorhinal field) and ME (medial entorhinal field). Cytoarchitectonically, the main difference between LEA and MEA is displayed by layer II neurons: while these are in a dense layer in LEA, they are more dispersed in MEA. Further, in LEA there is a relatively cell-free zone between layers II and III; this zone is not present in MEA. Histochemically, in acetylcholinesterase (AChE)-stained material, MEA is characterized by darker-stained bands in the superficial layer (i.e., layer I) and in the lamina dissecans, in contrast to LEA, which is more evenly stained for AChE. Further, both the border with the perirhinal cortex and the border with the parasubiculum are characterized by dark-stained bands of AChE. The border between the entorhinal cortex and perirhinal cortex is also easily distinguished in parvalbumin-stained material; while the entorhinal cortex is darkly stained, the perirhinal cortex is lightly stained. In contrast, in sections stained for calretinin, the entorhinal cortex is more lightly stained than the parasubiculum, which has a darkly stained superficial layer, and a densely stained group of neurons in layer III.

show abstract

Late post-learning participation of entorhinal cortex in memory processes

Cited by 26 publications

References 17 publications

The entorhinal cortex of the mouse: Organization of the projection to the hippocampal formation

The entorhinal cortex of the mouse: Organization of the projection to the hippocampal formation

Differential learning‐stage dependent patterns of c‐Fos protein expression in brain regions during the acquisition and memory consolidation of an operant task in mice

Entorhinal cortex of the mouse: Cytoarchitectonical organization

Contact Info

Product

Resources

About